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Metrical versions of the Passion form a significant part of the substantial body of devotional literature written in Europe during the 17th and 18th centuries. The aim underlying them was twofold: to meet the demand for works which could be used for purposes of educadon, edification, and private worship but also to show that the vanacul-ars could be used to produce distinguished works written in a

Popular Abstract in Swedish Peptidaser, proteolytiska enzymer eller proteinhydrolaser är olika benämningar på samma sorts enzymer. Deras funktion är att bryta ner proteiner i alla celler, vävnader eller vätskor i antingen vår egen kropp eller i någon annan levande organism. Varför behövs dessa enzymer? Deras funktion påminner om den av en återvinningscentral, där peptidaserna avvecklar felfungeraProteolytic enzymes are enzymes that hydrolyze peptide bonds in peptides and proteins. This ability to carry out protein degradation is essential for many cellular and extracellular processes that occur in all living organisms. Cysteine peptidases constitute a class of proteolytic enzymes. Among these, papain-like (C1) peptidases are the mostly studied ones. Inhibitors regulate proteolytic activit

Growth conditions on acid soils may be hampered by low nutrient availability and phytotoxic Al (aluminium) concentrations. In this thesis I present my studies on adaptation mechanisms of wild plants to acid soils in the close root environment, the rhizosphere. The studies showed that plants have developed several mechanisms that may work simultaneously to face the complex soil chemistry. A first g

OBJECTIVE: This study aimed to evaluate patients with bipolar I disorder (BD-I) who have mania with depressive symptoms and who meet the new "with mixed features" specifier of the Diagnostic and Statistical Manual of Mental Disorders, fifth edition (DSM-5).METHOD: This prospective, multinational, naturalistic study surveyed psychiatrists and their patients with BD-I from October 2013 to March 2014

The aggregation and deposition of amyloid-β (Aβ) peptides into plaques is an early event in Alzheimer's disease (AD), which is followed by different aspects of neurodegeneration that can be measured in the cerebrospinal fluid (CSF) or plasma using neurofilament light (NFL), neurogranin (Ng), total Tau (T-Tau), and phosphorylated tau (P-Tau) levels. The relationship between these biomarkers and reg

Introduction: It has traditionally been believed that early repolarization (ER) is benign. Significant association between ER and sudden cardiac arrest due to idiopathic ventricular fibrillation was recently found in a large cohort of adult survivors of sudden cardiac arrest. In some prior studies, unexplained syncope has been linked to risk of sudden death, but the mechanisms remain speculative.W

Energy-intensive processing industries like the concrete industry form the base of the economy and account for a large part of global greenhouse gas emissions. Sectoral transformation to cleaner basic materials is therefore crucial, and institutional pressure to do so is increasing. However, socio-technical studies have not sufficiently addressed these sectors. This paper therefore sets out to ana

Unbiased, “nontargeted” metabolite profiling techniques hold considerable promise for biomarker and pathway discovery, in spite of the lack of successful applications to human disease. By integrating nontargeted metabolomics, genetics, and detailed human phenotyping, we identified dimethylguanidino valeric acid (DMGV) as an independent biomarker of CT-defined nonalcoholic fatty liver disease (NAFL

Immune cell-derived cytotoxic pathways have been implicated in antitumor immune responses. The goal of this study is to characterize how these cytotoxic pathways influence ovarian cancer development. We have utilized the TgMISIIR-TAg transgenic mouse model which expresses the transforming SV40 TAg in the ovary, leading to spontaneous development of ovarian tumors that closely mimic human epithelia

The eutrophication problems in lakes on the Yangtze Plain of China have attracted global concern. However, a comprehensive assessment of the eutrophication status and its evolution is still lacking for these regional lakes, mostly because of technical difficulties and/or insufficient data to cover the large region. Our study attempts to fill this knowledge gap by using the entire archive of remote

The role of auditory feedback in vocal production has mainly been investigated by altered auditory feedback (AAF) in real time. In response, speakers compensate by shifting their speech output in the opposite direction. Current theory suggests this is caused by a mismatch between expected and observed feedback. A methodological issue is the difficulty to fully isolate the speaker’s hearing so that

Background Atopic dermatitis (AD) is caused by a complex interplay between immune and barrier abnormalities. Murine models of AD are essential for preclinical assessments of new treatments. Although many models have been used to simulate AD, their transcriptomic profiles are not fully understood, and a comparison of these models with the human AD transcriptomic fingerprint is lacking. Objective We

We have evaluated a method for synthesizing mammograms by comparing the texture of clinical and synthetic mammograms. The synthesis algorithm is based upon simulations of breast tissue and the mammographic imaging process. Mammogram texture was synthesized by projections of simulated adipose tissue compartments. It was hypothesized that the synthetic and clinical texture have similar properties, a

Stroke är en mycket vanlig sjukdom och idag räknar man med att det finns över 140 000 drabbade i Sverige som lever med varierande grad av funktionell nedsättning. Prognosen efter stroke påverkas av många olika faktorer varav flera tidigare inte fått så mycket uppmärksamhet. Den här avhandlingen ämnar ge en heltäckande bild av långtidsprognosen och varje delarbete fokuserar på olika viktiga aspekteBackground: Stroke is a major cause of mortality and disability. Prognosis is constantly evolving and is affected by multiple factors, many of which have not previously been thoroughly analyzed. This thesis aims to provide an updated and comprehensive description of long-term prognosis after stroke, specifically exploring key factors such as comorbidity (Study II), pre-stroke functional dependency

Background: The UICC TNM 7th edition introduced stage groups for anal cancer which in 2019 has not yet come into general use. The new TNM 8th edition from 2016 defines 7 sub-stages. Background data for these changes are lacking. We aimed to investigate whether the new classification for anal cancer reliably predict the prognosis in the different stages. Patients and methods: The Nordic Anal Cancer

Co-feeding of renewable feedstocks in general, and lignin streams in particular, in petroleum refineries is an attractive means of increasing the proportion of renewable fuel. Four separate units in an integrated refinery can be envisioned using lignin as a feedstock: the hydrotreater, the fluidised catalytic cracker, the hydrocracker and the slurry hydrotreater. A conceptual process design study,

Introduction: The prevalence of arthropathy in moderate haemophilia A (MHA) and B (MHB) is not well known. Aim: We evaluated joint health in Nordic patients in relation to their treatment modality. Methods: A cross-sectional, multicentre study covering MHA and MHB in Sweden, Finland and Norway. Arthropathy was evaluated by ultrasound (HEAD-US) and Haemophilia Joint Health Score (HJHS). Results: We