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Effektiv projektering av broar

Marknaden för brobyggnad i Sverige är idag så god att företagen tvingas tacka nej till förfrågningar på grund av tidsbrist. Det är svårt att rekrytera nya konsulter eftersom det råder brist på arbetskraft med rätt kompetens, för att undvika att tacka nej till arbete är en potentiell lösning på tidsbristen att effektivisera arbetet. I samarbete med Skanska Tekniks brogrupp i Malmö utreder därför deThe bridge construction industry in Sweden is prospering. The situation is such that companies are forced to decline work due to lack of time. In addition, the recruitment of new consultants has been difficult owing to a shortage of labour with the right competency. To avoid the situation where companies are forced to decline new projects due to lack of resources, focus should be on improving the

Att äga eller hyra lokaler? En analys av lönsamhet, hållbarhet och andra påverkande faktorer

Under de senaste åren har kontorsmarknaden varit under förändring, framför allt som en effekt av Covid-19-pandemin och teknisk innovation. Detta har påverkat hur kontorslokaler används och inneburit ett ökat utbud av fastighetsprodukter. Ett av de beslut som organisationer behöver ta är om de ska äga eller hyra sina lokaler, vilket är ett beslut styrt av flera parametrar. Det rätta beslutet för enIn recent years, the office market has been changing, mainly due to the Covid-19 pandemic and technological innovation. This has impacted how office space is used and has led to an increase in the range of available real estate products. One of the decisions organizations need to make is whether to own or lease their space, which is a decision driven by several parameters. The right decision for a

Lipoprotein-associated phospholipase A2 (Lp-PLA2) Impact and role as cardiovascular risk marker

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is today considered a novel specific vascular inflammatory biomarker. The general aim of this thesis was to study the role and impact of Lp-PLA2 as cardiovascular (CV) risk marker in an epidemiologic perspective. Specific aims were to explore the cross-sectional association of Lp-PLA2 with traditional CV risk factors, to asses the genetic influence

Diversity of Skin Infections

Popular Abstract in Swedish Det är väl känt att infektioner kan orsaka eller medverka till utveckling av vissa former av cancer hos människan. Cirka 20% av den globala cancerincidensen orsakas av infektioner. Patienter med nedsatt immunförsvar har en ökad förekomst av ett flertal virus-orsakade cancerformer, t.ex. livmoderhalscancer som orsakas av humant papillomvirus (HPV) och levercancer som orsThe identification of infectious agents in cancer has been one of the most rewarding endeavors in cancer research. Currently about 20% of the global cancer burden is linked to an infection. A common characteristic of virus-induced cancer is an increased incidence in immunosuppressed patients, presumably because of impaired host control of virus. Yet non-melanoma skin cancer (NMSC), the cancer that

Efficient Cluster-Based Catalysts for Asymmetric Hydrogenation of α-Unsaturated Carboxylic Acids.

The new clusters [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)], [H(4) Ru(4) (CO)(10) (1,1-P-P)] and [H(4) Ru(4) (CO)(11) (P-P)] (P-P=chiral diphosphine of the ferrocene-based Josiphos or Walphos ligand families) have been synthesised and characterised. The crystal and molecular structures of eleven clusters reveal that the coordination modes of the diphosphine in the [H(4) Ru(4) (CO)(10) (μ-1,2-P-P)] clusters

Analysis of borehole geophysical data from the Mora area of the Siljan Ring impact structure, central Sweden

The Siljan impact structure is the largest known impact structure in Europe, the result of a Late Devonian meteorite impact (380.9 +/- 4.6 Ma). It is outlined mainly by a ring of lakes and Palaeozoic sedimentary rocks of Ordovician to Devonian age. The Palaeozoic successions are generally poorly exposed, but often well preserved with clear stratigraphy. At some locations they are strongly tectonis

A numerical model of nearshore waves, currents, and sediment transport

A two-dimensional numerical model of nearshore waves, currents, and sediment transport was developed. The multi-directional random wave transformation model formulated by Mase [Mase, H., 2001. Multidirectional random wave transformation model based on energy balance equation. Coastal Engineering Jounnal 43(4), 317-337.] based on an energy balance equation was employed with an improved description

Miljonprogrammets Rosengård: den avbildade verkligheten

The purpose of this thesis is to cast light on the residential area Rosengård in Malmö which during the years between 1965 to 1975 was part of a programme known as "Miljonprogrammet", a project which was supposed to put an end to the housing shortages. The purpose of this thesis is also to investigate the social consequences in Rosengård, which arose as a result of Miljonprogrammet. Rose

Utformning av stationer i mindre samhällen

Summary The station has always played an important role in development. In Sweden, railway building started in the middle of the 1900th century. The government financed the main rail lines, while private railway companies financed the small lines. The expansion of the railway lines was lead and planned by militaries, therefore the stations generally were drawn by trained militaries. Several statio

Ferrochelatase deficiency causes a striped phenotype in barley Tigrina-b mutants

A mutation in ferrochelatase causes the tiger-like appearance of barley mutants The study of plants provides people with knowledge that can be used for a variety of purposes, including advances in agriculture, food production and nature conservation. Barley is an important crop that was domesticated about 10,000 years ago. It can self-fertilize, rarely crosses with other plant species and a singl

Immigrants’ diminished protective effects of parental education and employment on youth mood disorders in Sweden

Objectives: While high socioeconomic status (SES) indicators generally protect against mental health issues such as mood disorders in overall populations, evidence suggests that these protective effects might be attenuated for marginalized groups such as immigrants, in comparison to groups who are more socially privileged. This phenomenon is referred to as Marginalization-related Diminished Return

A genotype dependent intermediate ECG phenotype in patients with persistent lone atrial fibrillation

Background— Atrial fibrillation (AF) is heterogeneous at the clinical and molecular levels. Association studies have reported that common single-nucleotide polymorphisms in KCNE1 and SCN5A may predispose to AF. In this study, we tested the hypothesis that specific AF-associated genotypes confer variation on the appearance of AF assessed by analysis of fibrillatory rate of the atria. Methods and R

Human glandular kallikrein 2 (hK2) in prostate cancer: Clinical and Methodological studies

Popular Abstract in Swedish Prostata cancer är en av de vanligast förekommande cancerformerna hos män i västvärlden och den vanligaste förekommande hos män i Sverige. Årligen diagnosticeras i Sverige ungefär 6000 fall och mer än 2000 avlider. Drygt 70% av alla som drabbas är äldre än 70 år medan endast ett fåtal är yngre än 50 år. Sjukdomen ter sig mycket olika hos olika patienter. En del som drabHuman glandular kallikrein 2 (hK2) is a predominantly prostate produced protein with many similarities to prostate-specific antigen (PSA). Just like for PSA elevated levels of hK2 can be found in men with protate cancer. We created an assay where hK2 in serum could reliably and with negligible cross-reactivity with PSA, be measured down to 0.030 ng/mL. The assay measured free hK2 and hK2 complexe

User related assessment of Safe Cruise and Speed Support (VCC)

The aim of the user related assessment was to study perceived advantages, disadvantages, usefulness, trust, acceptance, willingness to have and pay for the driver assistance systems: Safe Cruise and Speed Support developed by VCC within the framework of SECONDS subproject. Due to restrictions in driving in real traffic, assessment activities were limited to driving on a test track by naïve test dr

Exploring Heterogeneity in Paediatric Type 1 Diabetes

Background and aim: Children with type 1 diabetes (T1D) represent a heterogeneous group of children with varying genetic backgrounds and different numbers of autoantibodies at diagnosis. The latter may reflect an interaction between genetic susceptibility and environmental triggers that contribute to the onset of the disease. However, the specific triggers remain unknown. The overall aim of this t

Agency and self-organised care experiences in Sweden's Collaborative Housing for the second half of life

In the Swedish context, ‘intergenerational Collaborative Housing’ and ‘Collaborative Housing for the second half of life’ (CH2L), based on the self-work model, were developed in the 1980s and 1990s. The chapter examines how ageing individuals developed caring practices and mutual support strategies in these collective housing forms and how such practices were adapted during the COVID-19 pandemic.

Enhancing individual glomerular filtration rate assessment : can we trust the equation? Development and validation of machine learning models to assess the trustworthiness of estimated GFR compared to measured GFR

Background: Creatinine-based estimated glomerular filtration rate (eGFR) equations are widely used in clinical practice but exhibit inherent limitations. On the other side, measuring GFR is time consuming and not available in routine clinical practice. We developed and validated machine learning models to assess the trustworthiness (i.e. the ability of equations to estimate measured GFR (mGFR) wit

Markers of inflammation predicts long-term mortality in patients with acute coronary syndrome – a cohort study

Background: Chronic low-grade inflammation is a well-known risk factor for coronary heart disease (CHD) and future cardiovascular events. Anti-inflammatory therapy can reduce the risk of ischemic cardiovascular disease (CVD) events following myocardial infarction (MI). However, it remains unknown to what extent inflammation at the time of an acute event predicts long-term outcomes. We explored whe

Predicting Occlusion Myocardial Infarctions in the Emergency Department Using Artificial Intelligence

ObjectivesThe objective was to develop an artificial intelligence (AI) model for predicting acute coronary occlusion myocardial infarction (OMI) in patients with chest pain at the emergency department (ED), using information that is widely available early in the ED assessment.MethodsIn a cohort of 24,511 consecutive adult ED patients with chest pain from 5 Swedish hospitals, OMI cases were identif

Proteomic analysis reveals angiogenesis-related plasma proteins associated with pre-eclampsia in SLE

Objective Delivery of a small for gestational age (SGA) infant is a common pregnancy complication among women with SLE. Although disease activity and autoantibodies such as anti-Smith and anti-ribonucleoprotein associate with SGA, underlying pathological mechanisms remain unclear and reliable predictors are lacking. To address this, we applied a proteomic approach to identify proteins associated w