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BACKGROUND: The rates of anterior cruciate ligament (ACL) graft failure or contralateral ACL rupture range from 17% to 30% in pediatric patients after ACL reconstruction (ACLR). A contributing factor to the high reinjury rate in this population may be the limited evidence regarding appropriate criteria for allowing unrestricted return to activity (RTA) postoperatively.PURPOSE: To review the litera
AbstractAim: The overall aim of the thesis was to examine the psychosocial effects and family reactions to participation in longitudinal studies with their children at high risk for type 1 diabetes. Additionally, we aimed to develop a shorter form for the children to measure their anxiety when thinking of their risk of developing type 1 diabetes, which could be used in The Environmental Determinan
Background: As gene-targeted therapies are increasingly being developed for Parkinson's disease (PD), identifying and characterizing carriers of specific genetic pathogenic variants is imperative. Only a small fraction of the estimated number of subjects with monogenic PD worldwide are currently represented in the literature and availability of clinical data and clinical trial-ready cohorts is lim
Seaweed is depicted as a future food in Western cultures, yet its introduction and expansion to new markets come with several challenges, including food neophobia and limited knowledge about its usability. To address these challenges, this study characterizes sensory perceptions, nutritional content, and physicochemical properties of four common northern European seaweed species, Saccharina latiss
Circular economy (CE) is still a nascent research field in the built environment, however, has gained traction in the last decade. Despite it being generally accepted that sustainability consists of three dimensions, namely, social, environmental, and economic, CE has been criticised for focusing on environmental and economic impact whilst neglecting the social aspect. Further, CE has been critici
Mitochondrial metabolism is entirely dependent on the biosynthesis of the [4Fe-4S] clusters, which are part of the subunits of the respiratory chain. The mitochondrial late ISC pathway mediates the formation of these clusters from simpler [2Fe-2S] molecules and transfers them to client proteins. Here, we characterized the late ISC pathway in one of the simplest mitochondria, mitosomes, of the anae
In order to obtain a higher thermal efficiency, the inlet temperature of gas turbines is gradually increased. However, this increases the thermal load on the first stage vane endwall surface. Therefore, an advanced cooling technique must be implemented for the endwall cooling to ensure that the gas turbine operates safely. In the current study, effects of swirling coolant flow from the upstream sl
The purpose of this study was to explore retina-intrinsic neuroinflammatory reactions, effects on neuronal survival, relationship with classic gliosis, and possible role of the toll-like receptor 4 (TLR4). To isolate the adult retina from the systemic immune system, a previously described large animal explant culture model was used in which full-thickness porcine retinal sheets can be kept in vitr
OBJECTIVE: To explore the treatment patterns of patients with a diagnosis related to chronic pain (DRCP) initiating pharmacological treatment indicated for neuropathic pain (NeuP: tricyclic antidepressants, serotonin-norepinephrine reuptake inhibitors, and anticonvulsants).DESIGN: Retrospective study on administrative registers.SETTING: General population in Western Sweden (one sixth of the countr
The burden of depression and anxiety disorders is greater in women, and female sex hormones have been shown to affect mood. Psychological side effects of hormonal contraception (HC) are also a common complaint in the clinic, but few previous studies have investigated this subject. We therefore wanted to investigate whether use of HC was associated with adverse psychological health outcomes, and wh
Background: The developmental study of subtypes of disordered eating (DE) during adolescence may be relevant to understand the development of eating disorders. The purpose of the present study was to identify subgroups with different profiles of DE in a community sample of adolescent girls aged 13-15 years, and to study the stability of these profiles and subgroups over a one-year interval in orde
Themembers of the paired box (Pax) family regulate key developmental pathways inmanymetazoans as tissue-specific transcription factors. Vertebrate genomes typically possess nine Pax genes (Pax1–9), which are derived from four proto-Pax genes in the vertebrate ancestor that were later expanded through the so-called two-round (2R) whole-genome duplication. A recent study proposed that pax6a genes of
Groundwater is a finite resource that is threatened by pollution all over the world. Shimabara City, Nagasaki, Japan, uses groundwater for its main water supply. During recent years, the city has experienced severe nitrate pollution in its groundwater. For better understanding of origin and impact of the pollution, chemical effects and surface–groundwater interactions need to be examined. For this
BACKGROUND:Although oxygen therapy has been used for over a century in the management of patients with suspected acute myocardial infarction (AMI), recent studies have raised concerns around the efficacy and safety of supplemental oxygen in normoxaemic patients.OBJECTIVE:To synthesise the evidence from randomised controlled trials (RCTs) that investigated the effects of supplemental oxygen therapy
Background and purpose: The purpose of this study was to investigate whether treatment information from medical records can be used to estimate radiation doses to heart and lungs retrospectively in pediatric patients receiving spinal irradiation with conventional posterior fields. Material and methods: An algorithm for retrospective dosimetry in children treated with spinal irradiation was develop
Objective: To define the role of ultrasound (US) for the assessment of patients with rheumatoid arthritis (RA) in clinical remission, including joint and tendon evaluation. Methods: A multicentre longitudinal study has been promoted by the US Study Group of the Italian Society for Rheumatology. 25 Italian centres participated, enrolling consecutive patients with RA in clinical remission. All patie
Dissolved organic carbon (DOC) loading is rarely estimated in tropical watersheds. This study quantifies DOC loading in the Rukarara River Watershed (RRW), a Rwandan tropical forest and agricultural watershed, and evaluates its relationship with hydrological factors, land use and land cover (LULC), and topography to better understand the impact of stream DOC export on watershed carbon budgets. The
Risk of dementia is increased in patients with atrial fibrillation (AF). We aimed to study associations between relevant comorbidities and prevalent as well as incident dementia in AF patients. Study population included all adults (n = 12,283) ≥ 45 years diagnosed with AF at 75 primary care centers in Sweden 2001–2007. Logistic regression was used to calculate odds ratios (OR) with 95% confidence
Background and purpose — Fast-track care programs in elective total hip and knee replacement (THR/TKR) have been introduced in several countries during the last decade resulting in a significant reduction of hospital stay without any rise in readmissions or early adverse events (AE). We evaluated the risk of readmissions and AE within 30 and 90 days after surgery when a fast-track program was intr
The human bone marrow (BM) gives rise to all distinct blood cell lineages, including CD1c+ (cDC2) and CD141+ (cDC1) myeloid dendritic cells (DC) and monocytes. These cell subsets are also present in peripheral blood (PB) and lymphoid tissues. However, the difference between the BM and PB compartment in terms of differentiation state and immunological role of DC is not yet known. The BM may represe
