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Purpose: The purpose of this paper is to determine associations between initially recorded deviations in individual bedside vital parameters that contribute to total Modified Early Warning Score (MEWS) levels 2 or 3 and further clinical deterioration (MEWS level=4). Design/methodology/approach: This was a prospective study in which 27,504 vital parameter values, corresponding to a total MEWS level
Background: Spirometry, the main tool for diagnosis and follow-up of COPD, incompletely describes the disease. Based on volumetric capnography (VCap), an index was developed for the diagnosis and grading of COPD, aimed as a complement or alternative to spirometry. Methods: Nine non-smokers, 10 smokers/former smokers without COPD and 54 smokers/ former smokers with COPD were included in the study.
Background: Several factors have been reported that influence the probability of a germline CDKN2A mutation in a melanoma family. Our goal was to create a scoring system to estimate this probability, based on a set of clinical features present in the patient and his or her family. Methods: Five clinical features and their association with CDKN2A mutations were investigated in a training cohort of
Aims: Chronic left atrial enlargement (LAE) increases the risk of atrial fibrillation. Electrocardiogram (ECG) criteria might provide a means to diagnose LAE and identify patients at risk; however, current criteria perform poorly. We seek to characterize the potentially differential effects of atrial dilation vs. hypertrophy on the ECG P-wave. Methods and results: We predict effects on the P-wave
Objective: To investigate health-related quality of life (HrQoL) and adaptive behavior in young people with narcolepsy and stress among their parents. Methods: In a cross-sectional exploratory quantitative study design, 37 young people with narcolepsy (8–20 years of age) and their parents were recruited. Thirty-one had post-H1N1 vaccination-related narcolepsy (PHV) and six had narcolepsy not relat
Background. Multidisciplinary team (MDT) conferences have been introduced into standard cancer care, though evidence that it benefits the patient is weak. We used the national Swedish Rectal Cancer Register to evaluate predictors for case discussion at a MDT conference and its impact on treatment. Material and methods. Of the 6760 patients diagnosed with rectal cancer in Sweden between 2007 and 20
Context The relationship of platelet function testing measurements with outcomes in patients with acute coronary syndromes (ACS) initially managed medically without revascularization is unknown. Objective To characterize the differences and evaluate clinical outcomes associated with platelet reactivity among patients with ACS treated with clopidogrel or prasugrel. Design, Setting, and Patients Pat
Viral vector-mediated gene transfer has emerged as a powerful means to target transgene expression in the central nervous system. Here we characterized the efficacy of serotypes 1 and 5 recombinant adeno-associated virus (rAAV) vectors encoding green fluorescent protein (GFP) after stereotaxic delivery to the neonatal rat and minipig striatum. The efficiency of GFP expression and the phenotype of
Tyrosine kinase inhibitors have greatly improved the prognosis of chronic myeloid leukemia (CML). In addition to direct kinase inhibition, their effects can also be mediated through immune modulation, such as expansion of cytotoxic T and natural-killer cells observed during dasatinib therapy. As natural-killer cell and partially CD8(+) T-cell function are regulated by killer immunoglobulin-like re
Objective: The objective was to assess the long-term safety profile of dual-release hydrocortisone (DR-HC) in patients with adrenal insufficiency. Design: Randomized, open-label, crossover trial of DR-HC or thrice-daily hydrocortisone for 3 months each (stage 1) followed by two consecutive, prospective, open-label studies of DR-HC for 6 months (stage 2) and 18 months (stage 3) at five university c
When in need to tell stories we often find ourselves using not only our words but also accompanying gestures, as well as pictures. However, what if we were to use only gestures to narrate? Would the stories we tell be clear enough to understand? The thesis investigates the potentials and limitations of pantomime, which consists mostly of gesture, for storytelling. Concretely, through a unique two-
Sedan 1700-talet har 87 procent av världens våtmarker försvunnit, med en acceleration under de senaste 50 åren där mer än en tredjedel av världens våtmarker försvunnit på grund av exploatering. Våtmarker bidrar med många viktiga funktioner, såsom klimateglering genom att minska översvämningar och torka samt genom att agera som naturliga reningsverk. I takt med klimatförändringarna har våtmarkers fWetlands play a vital role globally in protecting biodiversity, purifying water, and mitigating floods. In Kigali, Rwanda’s capital, five natural wetlands are located in the city center. This master’s thesis aimed to evaluate the water quality of these wetlands and identify key pollution sources. The aim was also to analyse changes in water quality over time with respect to changes in demographics
Enhancing the physicochemical and sensory properties of flavoured vodkas using hydrocolloids is of significant interest to the beverage industry. Hydrocolloids like xanthan gum and carboxymethyl cellulose (CMC) can influence texture and stability, yet their specific impacts in alcoholic systems are underexplored. This study aims to evaluate the effect of hydrocolloids on the viscosity, turbidity,
The purpose of this thesis was to investigate how financial violence is identified and to determine the measures taken by professionals working with financial assistance in social services, focused on financially abused women. In this thesis, a qualitative research approach was applied, where data is collected through semi-structured interviews with professionally active social workers within fina
År 2019 introducerade EU det så kallade visselblåsardirektivet. Direktivet tillkom för att komma till rätta med oegentligheter på den inre marknaden och stärka skyddsnivån för visselblåsare. Till följd av direktivets nya krav och bestämmelser behövde samtliga medlemsstater i EU ändra sin nationella lagstiftning på området. Enligt direktivet ska varje rättslig enhet med 50 eller fler arbetstagare hIn 2019, the EU introduced the so-called Whistleblower Directive. The directive was established to address misconduct in the internal market and strengthen the level of protection for whistleblowers. As a result of the directive's new regulations, all EU member states needed to amend their national legislation in this area. According to the directive, every legal entity with 50 or more employe
Att vilja vara kvar: faktorer som får vårdens medarbetare att trivas Sjukvården i Sverige står inför en av de största utmaningarna någonsin: hur ska vi säkra att det finns tillräckligt med kompetent personal i framtiden – både i den offentliga och privata vården? Regeringen satsar stora resurser på att kartlägga behoven och hitta lösningar, men det krävs fortfarande mer forskning för att verkligeThe Swedish healthcare system is facing a substantial challenge in competence provision, with skilled staff needed in both the private and public sectors. The Swedish government is investing heavily in initiatives and mapping projects aimed at securing future competence supply. This study aims to identify which factors have the greatest impact on healthcare employees' decisions to either leav
Leukemi kallas ibland blodcancer för att det drabbar de vita blodkropparna. I själva verket uppstår cancersjukdomen i de blodbildande organen, främst benmärgen och mjälten. Cellgiftsbehandling är den främsta behandlingstekniken men för patienter med hög risk för sjukdomsåterfall kan stamcellstransplantation vara aktuellt som del i behandlingen som ges i kombination med strålbehandling. StrålbehandBackground: Total marrow irradiation (TMI) with helical tomotherapy treatment (HT-TMI) can be used as conditioning regimen for leukemia patients prior to stem cell transplantation by radiating the skeletal tissue. To ensure adequate dose coverage a margin is applied to the clinical target volume (CTV), i.e. planning target volume (PTV) margin. By applying as small margin as possible the dose to or
Med de nya klimatomställningarna behövs nya hållbara material. En av de mest förekom-mande naturliga molekylerna är lignin, vilket är en av de tre huvudsakliga beståndsdelarna i växter, till exempel trä. Förutom lignin är de två andra huvudbeståndsdelarna i trä; cellulosa och hemicellulosa. Idag används framför allt cellulosa i pappersindustrin och lignin har därför länge ansetts vara en restproduThe two by-products lignin, from the paper industry, and zein, from starch production, have shown potential as hydrophobic barriers. Therefore, this study has aimed to produce and in-vestigate the hydrophobicity of lignin or zein dispersions coated on paper. The lignin coatings were made from softwood (spruce) and hardwood (birch) lignin that was extracted using hy-drotropic extraction (HEX) and m
Thesis purpose: The current study examines the association between seven variables: environmental sustainability, perceived functionality, social influence, price value, hedonic motivation, uniqueness, and technology habit with the purchase of second-hand clothing on peer-to-peer platforms on a regular basis. Theoretical perspective: Venkatesh, Thong and Xu’s (2012) Extended Unified Theory of Acc
The purpose of this master’s thesis is to illuminate the information practices of professional musicians in the field of Early music. These musicians have a special interest in exploring the performance practices of the time periods when the music was composed, to make it more vivid in the present. This more and more widespread approach to Early music is called Historically Informed Performance (H
