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Children undergoing surgery for posterior fossa tumours (PFT) may experience postoperative language and communication difficulties, regardless of whether they develop cerebellar mutism syndrome (CMS) or not. While these language difficulties are increasingly recognised in current research, children’s own experiences of everyday communication remain limited. In this presentation, we share findings
Background: Patients with diabetes admitted to emergency care face a higher risk of complications, including prolonged hospital stays, admissions to the intensive care unit and mortality. Aim: To develop a machine learning (ML) model to predict 30-day mortality in patients with diabetes admitted to the emergency department (ED). Design and setting: A cohort study utilizing data from all nine ED’s
The purple color of the barley (Hordeum vulgare L.) grain is attributed to anthocyanins which are beneficial for human health. Synthesis of these pigments in both grain and vegetative tissues is controlled by ANT1 and ANT2 that belong to the families R2R3-MYB and bHLH of transcription factors, respectively. Here, we investigated the role of the Ant2 gene in pigmentation of grains compared to veget
Objectives Assessment of Different NEoplasias in the adneXa (ADNEX) and Risk of Malignancy Index (RMI) are models that estimate the risk of malignancy in ovarian masses based on clinical and ultrasound information. The aim is to perform a meta-analysis of studies that compared the performance of the two models in the same patients (‘head-to-head comparison’). Design Systematic review and meta-anal
Background: Preparing retrospective dose data for risk modeling using large study cohorts can be time consuming as it often requires patient-wise manual interventions. This is especially the case when considering organs at risk (OARs) not systematically delineated historically. Therefore, we aimed to develop and test a semi-automated workflow for cohort-wise preparation of radiotherapy data from t
Background and purpose: The study aims to evaluate dosimetric properties of hypofractionated treatment plans integrating focal boost, using registered whole-mount histopathology (WMHP) as reference standard. Methods: Fifteen men from the PAMP trial (EudraCT: 2015-005046-55) were included. Participants had ≥ 1 ISUP Grade group ≥ 4 lesion and underwent [68Ga]prostate-specific membrane antigen (PSMA)
This PhD project aimed to investigate cerebellar contribution to cognition from a translational perspective by integrating neuropsychological assessment and neuroimaging, incorporating neurocognitive and motor tests with 7T Magnetic resonance imaging (MRI). The results are clinically significant as they identify nonverbal cognitive deficits that often may go unnoticed in clinical practice, particu
OBJECTIVES: Asphalt is frequently used as road pavement and consists of bitumen as a binder, and fillers. Bitumen consists of a complex mixture of hydrocarbons, where a minor component is polycyclic aromatic hydrocarbons (PAHs). Many PAHs are classified as carcinogenic to humans. Bitumen fumes from road paving have been classified as possibly carcinogenic. Paving and milling are open processes gen
A systematic assessment of radiotherapy for cancer was conducted by The Swedish Council on Technology Assessment in Health Care (SBU) in 2001. The assessment included a review of radiotherapy techniques in current use in Sweden. The following conclusions were drawn: Radiotherapy demands adequate knowledge of diagnostic methods, anatomy, cancer biology and of the physical and biological properties
In Sweden, the combination of the country’s natural ecological vulnerability to acidification and its geographical location has been domestic focal points for the treatment of the ‘acid rain’ issue. Political interest in the acidification issue in Sweden emerged in the late 1960s, when the problems of long-range transport of sulphuric compounds and their harmful environmental effects were first hi
Popular Abstract in Swedish Blodbildande stamceller förekommer i mänsklig benmärg i en frekvens på ca 1/100 000 celler. Med hjälp av cellytemarkörer, t.ex. CD34, kan man rena fram cellpopulationer som är anrikade på stamceller, men det saknas exakt kunskap om hur enskilda stamceller ser ut. De blodbildande stamcellerna har förmåga att vid celldelning antingen förnya sig själva eller att mogna ut. Hematopoietic stem cells (HSCs) have the capacity to maintain hematopoiesis throughout life. HSCs are ideal targets for permanent gene transfer, as the transgene will be expressed in all the progeny of the gene-modified stem cells. The aim of this thesis was to optimize conditions for retroviral gene transfer to human candidate HSCs and to study mechanisms interfering with efficient gene transfer.
Combining the strengths of an advanced mathematical model of human physiology and a thermal manikin is a new paradigm for simulating thermal behaviour of humans. However, the forerunners of such adaptive manikins showed some substantial limitations. This project aimed to determine the opportunities and constraints of the existing thermal manikins when dynamically controlled by a mathematical model
This thesis is a study of landownership that took place in Scania in southern Sweden in the 1860s. Basically it was a conflict between an alliance of tenant farmers and rural poor against estate owners in a time of agrarian change, a time characterized by mass evections of tenants and increasing proletarization. The participants of the movement, led by the self-taught lawyer Samuel Tullberg, claim
Popular Abstract in Swedish En främre korsbandsskada i knäet betraktas allmänt som en ganska allvarlig knäskada med risk för kvarstående funktionsnedsättning. Sett över tiden finns även en ökad risk för artros, ”brosknedbrytning”, efter främre korsbandsskada. Traditionellt sett har man inom ortopedin främst diskuterat vikten av främre korsbandets mekaniskt stabiliserande funktion; en skada, rupturProprioceptive ability was estimated in different groups of patients with anterior cruciate ligament (ACL) injury as well as in different groups of healthy uninjured individuals. In study I, patients with poor outcome of the ACL injury – i.e. persistent symptoms of instability – were compared with patients with few symptoms after ACL injury, as well as with a control group. The results showed that
The purpose of this thesis is to characterize the health status of the population in early Lund. This is pursued by an osteological analysis of 3.305 individuals fron three time periods: c. 990-1100, c. 1100-1300 and c. 1300-1536. The individuals derives from cemeteries connected to four neighbouring churches, where one is the sucessor of the other (Trinitatis). One cemetery (Kattesund) is by and
Genome structure has been found to be highly conserved between distantly related birds and recent data for a limited part of the genome suggest that this is true also for the gene order (synteny) within chromosomes. Here, we confirm that synteny is maintained for large chromosomal regions in chicken and a passerine bird, the great reed warbler Acrocephalus arundinaceus, with few rearrangements, bu
Aims/hypothesis. Fat accumulation in the liver has been shown to be closely correlated with hepatic insulin resistance and features of insulin resistance, also independently of body weight. It remains to be established how fat in the liver correlates with that in other depots, and whether any association differs between men and women. Methods. Liver fat (assessed using proton spectroscopy), intra-
Some case reports have shown that patients suffering from obsessive-compulsive disorder can be effectively treated with anti-androgenic pharmacological agents with various modes of action. The most effective group of such agents is the long-acting analogues of the gonadotropin-releasing hormone. This investigation was undertaken in order to further elucidate the possibility of using such powerful
