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The role of PIP5K1α/pAKT and targeted inhibition of growth of subtypes of breast cancer using PIP5K1α inhibitor

Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1Despite recent improvement in adjuvant therapies, triple-negative, and ER+ subtypes of breast cancer (BC) with metastatic potentials remain the leading cause of BC-related deaths. We investigated the role of phosphatidylinositol-4-phosphate 5-kinase alpha (PIP5Kα), a key upstream factor of PI3K/AKT, and the therapeutic effect of PIP5Kα inhibitor on subtypes of BC. The clinical importance of PIP5K1

Intra-organizational trust as a determinant of job satisfaction in the public sector. A case study of the Swedish Public Employment Service

From a managerial perspective, organizational effectiveness, whether internal or external, is of extreme importance. Therefore, management studies should investigate which phenomena need to be emphasized and safeguarded to utilize organizational effectiveness. Intra-organizational trust and job satisfaction are both defined as phenomena that are of influence on organizational effectiveness. This s

Cataloque Sky Is The Limit 2024

The Sky is The Limit The Sky is The Limit Stockholm Furniture Fair 06.02.2024-10.02.2024 School of Architecture Lund University Under hösten 2023 har tvåorna på Arkitektutbildningen i Lund studerat en kurs i gestaltningsprocess och prototyp. I två månaders tid har varje grupp formgivit en möbel och ett klädesplagg för årets tema The Sky is the Limit. Denna katalog är en översikt över samtliga proj

https://www.architecture.lth.se/sites/architecture.lth.se/files/2026-03/Cataloque%20Sky%20is%20the%20limit%202024.pdf - 2026-06-08

A data management framework for strategic urban planning using blue-green infrastructure

Spatial planning of Blue-Green Infrastructure (BGI) should ideally be based on well-evaluated and context specific solutions. One important obstacle to reach this goal relates to adequate provisioning of data to ensure good governance of BGI, i.e., appropriate planning, design, construction, and maintenance. This study explores the gap between data availability and implementation of BGI in urban p

Sovereignty and Bureaucracy in the Official Public Theories of the "Refugee Crisis" of 2015 in Sweden

In 2017, the Swedish government published an official report entitled "Att ta emot människor på flykt: Sverige hösten 2015." The report describes how Swedish state agencies, municipalities, and civil society conceptualized and managed the refugee crisis of 2015. This chapter spells out the official public theories expressed in this report and in doing so unfolds two key findings. First, the govern

Within-day energy deficiency and reproductive function in female endurance athletes

We aimed to estimate and compare within-day energy balance (WDEB) in athletes with eumenorrhea and menstrual dysfunction (MD) with similar 24-hour energy availability/energy balance (EA/EB). Furthermore, to investigate whether within-day energy deficiency is associated with resting metabolic rate (RMR), body-composition, S-cortisol, estradiol, T3 , and fasting blood glucose. We reanalyzed 7-day di

European-Code-of-Conduct-Revised-Edition-2023

1 The European Code of Conduct for Research Integrity REVISED EDITION 2023 Published in Berlin by ALLEA | All European Academies June 2023 Citation For citation purposes, please use the following: ALLEA (2023) The European Code of Conduct for Research Integrity – Revised Edition 2023. Berlin. DOI 10.26356/ECOC ISBN 978-3-9823562-3-5 Licence This work is licensed under the terms of the Creative Com

https://www.more-lab.lu.se/sites/more-lab.lu.se/files/2024-01/European-Code-of-Conduct-Revised-Edition-2023.pdf - 2026-06-08

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1 1 Discussion Paper on Biosphere Defenders in Latin America and the Caribbean & Written comments to the Escazu Agreement’s Draft Regional Action Plan on Human Rights Defenders in Environmental Matters By the Glawcal Lab at the Raoul Wallenberg Institute with The Global Network for Human Rights and the Environment. Authors: Claudia Ituarte-Lima, Natalia Urzola, Valentina Lomanto, Neshan Gunasekera

https://rwi.lu.se/wp-content/uploads/2024/06/DiscussionPaperDefendersLAC4CommentsEnglish.pdf - 2026-06-07

Roland Paulsen

Universitetslektor Kontaktinformation E-post: roland [dot] paulsen [at] fek [dot] lu [dot] seOrganisation Organisation Hämtställe: 10 WebbplatsRoland Paulsens profil i Lunds universitets forskningsportalPersonlig webbplats:https://www.rolandpaulsen.orgAndra roller Docent Organisation Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaArtikel i tidskriftB

https://www.ehl.lu.se/roland-paulsen - 2026-06-07

Hur vinner vi matchen mot idrottsrelaterad brottslighet? - En granskning av tillträdesförbudslagen och tre förslag

Idrottsrelaterad brottslighet är inget nytt fenomen. Det är dock ett problem som alltmer hamnat i fokus. Från att mer eller mindre ansetts vara ett idrottsproblem har det gradvist övergått till att även bli ett samhällsproblem. Idrottsrelaterad brottslighet påverkar både idrottsrörelsen samt samhället i stort. Minskade publiksiffror och intäktsbortfall från sponsorer är enbart en del av alla negat

Sports-related injuries in athletes with disabilities.

The number of athletes with disabilities participating in organized sports and the popularity of the Paralympic Games is steadily increasing around the world. Despite this growing interest and the fact that participation in sports places the athlete at risk for injury, there are few studies concerning injury patterns, risk factors, and prevention strategies of injuries in disabled athletes. In thi

Exploring Processor and Memory Architectures for Multimedia

Popular Abstract in English Consumption of multimedia content is one of the main tasks we perform in our day-to- day lives, such as listening to music on an iPod or watching the news from an online steaming service. As technology has evolved and enabled easier access to different content (basically access anything anywhere), our consumption has grown. In only the last decades we have evolved from Multimedia has become one of the cornerstones of our 21st century society and, when combined with mobility, has enabled a tremendous evolution of our society. However, joining these two concepts introduces many technical challenges. These range from having sufficient performance for handling multimedia content to having the battery stamina for acceptable mobile usage. When taking a projection of w

Lindvall et al lancet 1988

PII: S0140673688909506 1483 (p 1150). More appropriate advice was given to pharmacists in the Pharmaceutical journal (Dec 3, 1988, p 707) in a letter from the secretary of the professional advisory committee, British Diabetic Association. Ashton Postgraduate Medical Centre, Tameside General Hospital, Ashton under Lyne, Lancashire OL6 9RW N. M. O’MULLANE T. A. TURNER A. SIVNER M. HEALEY DARREN WALT

https://www.wnc.lu.se/sites/wnc.lu.se/files/lindvall_et_al_lancet_1988.pdf - 2026-06-08

Why the Social Connection Model Fails : Participation is Neither Necessary nor Sufficient for Political Responsibility

Iris Marion Young presents a social connection model on which those, and only those, who participate in structural processes that produce injustice have a forward-looking responsibility to redress the resulting injustice by challenging the structures that produce it (she sometimes calls this a political responsibility [Young 2011]). In Young's view, this is an all-things-considered, albeit discret

Changes in self-reported web-based gambling activity during the COVID-19 pandemic : Cross-sectional study

Background: The COVID-19 pandemic has affected not only somatic health with over 3.7 million deaths worldwide, but also has had a huge impact on psychological health, creating what amounts to a mental health crisis. The negative effect of the pandemic on traditional addictions is well described and concerning, and the same has been seen for gambling. Objective: This study explores self-reported we