Filtyp
Characterization of porous media is essential in a wide range of biomedical and industrial applications. Microstructural features can be probed non-invasively by diffusion magnetic resonance imaging (dMRI). However, diffusion encoding in conventional dMRI may yield similar signatures for very different microstructures, which represents a significant limitation for disentangling individual microstr
The effect of immunizing healthy individuals with either tetanus toxoid or yellow fever live attenuated vaccine was examined by measuring interferon (IFN)-dependent oligoadenylate synthetase (2-5A) activity. This enzyme converts ATP into oligonucleotides coupled together in 2'-5' diester bonds. The synthetized products possess among other effects growth inhibiting properties and stimulate a latent
Methods have been developed for the isolation on a semi-micro scale of a plasma membrane-enriched fraction from rat islets of Langerhans. An important feature of these experiments is the use of 125I-labeled wheat germ agglutinin as a specific probe for plasma membrane-containing fractions. The partly purified plasma membrane fraction had a density in sucrose of about 1.10 and was enriched in the a
Photonic materials for high-temperature applications need to withstand temperatures usually higher than 1000 °C, whilst keeping their function. When exposed to high temperatures, such nanostructured materials are prone to detrimental morphological changes, however the structure evolution pathway of photonic materials and its correlation with the loss of material's function is not yet fully underst
This study investigates the impacts of future climate uncertainties in the new generation of future climate data sets according to AR5(5 th assessment report of IPCC) on simulating the energy performance of buildings by studying the building stock in Germany (Potsdam). This work is based on two data bases, namely 'Tabula web tool-European building' and 'EPISCOP'. Software IDA ICE was used to make
Very limited data are available on sex ratios in familial cancer. Such data would be valuable in the assessment of sex chromosome effects and of interactions between background and familial rates. We used the nationwide Swedish Family-Cancer Database on 10.2 million individuals and over 1 million neoplasms to analyze familial risks for male and female offspring by paternal and maternal concordant
The porous aquifers in the area called Challapampa are the most important groundwater reservoirs that supply drinking water to Oruro city in the highlands of Bolivia. They consist of unconsolidated fluvial–lacustrine deposits, resting on a complex sedimentary bedrock and covered by a thin surficial clay layer. The settings of these geological units and the structures governing the flow patterns ha
Background: Uncomplicated urinary tract infection (uUTI) is common and a majority of patients are prescribed antibiotics. There is little knowledge about antibiotic resistance in urine samples from patients with uUTI in primary health care (PHC). The aim was to describe antibiotic treatment, bacterial findings, the prevalence of resistant E.coli and factors associated with antibiotic resistance. T
A composite approach was used for the structure solution and refinement of two new Nowotny chimney-ladder phases, (Mo/Rh)11Ge18 and (Mo/Rh)13Ge22, found during investigations in the Mo/Rh/Ge system. The descriptions of the phases with conventional models (in I4̄2d (No. 122) with a = 5.885(2) Å, c = 52.62(2) Å for (Mo/Rh)11Ge18 and a = 5.922(1) Å, c = 62.88(4) Å for (Mo/Rh)13Ge22) led to high numbe
Transposable elements (TEs) are dynamically expressed at high levels in multiple human tissues, but the function of TE-derived transcripts remains largely unknown. In this study, we identify numerous TE-derived microRNAs (miRNAs) by conducting Argonaute2 RNA immunoprecipitation followed by small RNA sequencing (AGO2 RIP-seq) on human brain tissue. Many of these miRNAs originated from LINE-2 (L2) e
In Case C-364/13 International Stem Cell Corporation (ISCC) v. Comptroller General of Patents (December 18th, 2014), the Court of Justice of the European Union (CJEU) distinguished its’ earlier ruling in Brüstle v. Greenpeace (Brüstle) with regard to non-fertilized human ova stimulated by parthenogenesis. The Court found that in order to be considered a ‘human embryo’- and thus to be unpatentable
Two approximation methods are presented for fast calculations of the monostatic scattering from axially symmetric scatterers coated with electromagnetic absorbers. The methods are designed for plane wave illumination parallel to the axis of rotation of the scatterer. The first method is based on simulating the scattering of a perfect electric conductor (PEC) enclosing the absorber coated scatterer
The thermal reduction of cerium oxide nanostructures deposited on a rhodium(111) single crystal surface and the re-oxidation of the structures by exposure to CO2 were investigated. Two samples are compared: a rhodium surface covered to ≈60% by one to two O-Ce-O trilayer high islands and a surface covered to ≈65% by islands of four O-Ce-O trilayer thickness. Two main results stand out: (1) the thin
An important issue in quantitative trait loci (QTL) detection is the use of phenotypic measurement as a dependent variable. Daughter yield deviations (DYDs) as the unit of choice are not available for all traits of interest. The use of de-regressed proofs (DRPFs) of estimated breeding values (EBVs) is an alternative to using daughter yield deviations. The objective of this study was to examine pos
Genes and proteins are known to have differences in their sensitivity to alterations. Despite numerous sequencing studies, proportions of harmful and harmless substitutions are not known for proteins and groups of proteins. To address this question, we predicted the outcome for all possible single amino acid substitutions (AASs) in nine representative protein groups by using the PON-P2 method. The
Cytochromes of c-type contain covalently bound haem and in bacteria are located on the periplasmic side of the cytoplasmic membrane. More than eight different gene products have been identified as being specifically required for the synthesis of cytochromes c in Gram-negative bacteria. Corresponding genes are not found in the genome sequences of Gram-positive bacteria. Using two random mutagenesis
In light of the biomedical interest for self-assembling amphiphiles bearing the tripeptide Arg-Gly-Gly (RGD), a cholic acid derivative was synthesized by introducing an aromatic moiety on the steroidal skeleton and the RGD sequence on the carboxylic function of its chain 17–24, thus forming a peptide amphiphile with the unconventional rigid amphiphilic structure of bile salts. In aqueous solution,
Svensk sammanfattningAvhandlingens syfte har varit att studera utvecklingen av en könskromosom i realtid genom att simulera dess framväxt i en hermafroditisk plattmask i laboratoriet. Jag gjorde detta genom att selektera på dels honlig fitness (fitness via ägg), dels hanlig fitness (fitness via spermier) med hjälp av en genetisk markör, som agerade som en könsbestämmande gen. Detta ska efterlikna Sex chromosome evolution in a hermaphrodite ancestor starts with the establishment of a sex-determining region (SDR). Over time, sex-specific genes, and/or sexually antagonistic alleles will become linked to the SDR. Sexually antagonistic alleles are a type of genetic variation that increases fitness for one sex while being detrimental for the other sex. Recombination arrest around the SDR and gen
