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Despite new therapies, castration-resistant prostate cancer (CRPC) is still incurable. Intercellular Adhesion Molecule 1 (ICAM-1) is a well-characterized cell surface protein involved in prostate cancer pathogenesis, differentially expressed during transition from hormone-sensitive to CRPC. This study aimed to investigate ICAM-1 as a target for imaging and radioimmunotherapy of CRPC.Anti-ICAM-1 an
Artificial intelligence (AI) is rapidly transforming healthcare, yet its successful integration depends heavily on the acceptance and understanding of this technology by medical professionals. Our qualitative exploratory study, using semi-structured interviews with eight medical professionals in Sweden and Denmark, charts their perceptions of AI's implementation in medicine. The primary goal o
Microsoft Word - Anställningspolicy_beslutad US18juni2019§6b 1 POLICY OM ANSTÄLLNING OCH GODA OCH TYDLIGA KARRIÄRVÄGAR FÖR LÄRARE OCH FORSKARE VID LUNDS UNIVERSITET Fastställd av universitetsstyrelsen 2019-06-18, §6b Inledning och syfte Lunds universitet är ett fullskaligt, forskningsintensivt, mångfacetterat och decentraliserat universitet. Att främja goda och tydliga karriärvägar i alla delar
Responsibility to Protect is a principle that has developed from a report written by ICISS in 2001. The report was inspired by a statement of Kofi Annan where he questioned how the international community would stop another incident like Rwanda or Srebrenica. Since then many situations have occurred that has challenged the concept of R2P. The debate about humanitarian interventions based on intern
Idrottsrörelsen är i dag Sveriges största folkrörelse och idrotten är världen över en angelägenhet för väldigt många människor. Idrottsrörelsen har en lång tradition av autonomi och självbestämmande, som tillsammans med en tilltagande kommersialisering har förstärkts av ett stort användande av skiljeavtal och egna skiljenämnder. Detta har gett upphov till frågan när allmänna domstolar egentligen b
The capacity to learn and reproduce vocal sounds has evolved in phylogenetically distant tetrapod lineages. Vocal learners in all these lineages express similar neural circuitry and genetic factors when perceiving, processing, and reproducing vocalization, suggesting that brain pathways for vocal learning evolved within strong constraints from a common ancestor, potentially fish. We hypothesize th
Background and aimHypoxic-ischaemic encephalopathy (HIE) is a leading cause of morbidity and mortality in unconscious patients resuscitated after out-of-hospital cardiac arrest. Many patients die after withdrawal of life-sustaining treatments (WLST), often due to a presumed poor prognosis. To minimise the risk of premature WLST, guidelines recommend using a multimodal prognostication. Head compute
Due to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and soDue to the increasing share of older people worldwide, the United Nations has directed an initiative towards a "decade of healthy ageing" to promote "age-friendly environments". This study aims to gain a deeper understanding of how to promote social participation and everyday mobility in later life. The ambition is to increase the knowledge about how to create more age-friendly environments and so
This thesis examines the continuity, change and adaptation of blat – as a Soviet time, informal economic transaction network, that existed as a response to a non-functional economy. The analysis is based on 33 in-depth interviews conducted in 2009 during a field study in Ukraine and Belarus. The main focus is on individuals’ descriptions, justifications and explanations of their ongoing informal p
BackgroundDespite the fact that eldercare services are organizationally part of social work in Sweden, the social work practice is disappearing and older people are expected to take the responsibility for their own well-being. In this context, they have to create their own sense of meaningfulness in their everyday life, despite being subject to social care services.Methods As part of a research pr
The purposes of this article-based thesis are to explore and understand preaching as a practice in general, and the practice of preaching in digital culture and spaces in particular. Informed by the practice theory of Theodore Schatzki, it presents the results of a cross-case analysis of four different case studies of the practice of preaching in digital culture and spaces in Swedish protestant chThe purposes of this article-based thesis are to explore and understand preaching as a practice in general, and the practice of preaching in digital culture and spaces in particular. Informed by the practice theory of Theodore Schatzki, it presents the results of a cross-case analysis of four different case studiesof the practice of preaching in digital culture and spaces in Swedish protestant chu
Due to social and environmental crises, the concept of sustainability has grown in importance in our society over the past years. Things are changing, even in the financial industry. From the perspective of investors, the general public, and enterprises, Corporate Social Responsibility and the creation of sustainable value are becoming more and more significant. One of the most cutting-edge tools
Purpose: The purpose of this paper is to shed light on which role authenticity plays in mobile dating apps, an environment where users can present themselves only with a limited amount of information. By investigating how users create their profiles and evaluate others, the existing knowledge on authenticity and self-presentation can be advanced. Methodology: The research applied a relativist and
The kinin B1 receptor (B1R) is a G protein-coupled receptor with pro-inflammatory activity that is latent in healthy tissues but induced by tissue insult. Here, we investigated if B1R homo-oligomerization is a possible mechanism regulating the presentation of this receptor at the level of maturation and trafficking to the cell surface. To this end, we used HEK293 cells stably expressing N-terminal
Transforming growth factor-beta (TGF-beta) is involved in vascular formation through activin receptor-like kinase (ALK)1 and ALK5. ALK5, which is expressed ubiquitously, phosphorylates Smad2 and Smad3, whereas endothelial cell (EC)-specific ALK1 activates Smad1 and Smad5. Because ALK5 kinase activity is required for ALK1 to transduce TGF-beta signaling via Smad1/5 in ECs, ALK5 knockout (KO) mice w
We have previously shown that protein kinase Cepsilon (PKCepsilon) induces neurite outgrowth via its regulatory domain and independently of its kinase activity. This study aimed at identifying mechanisms regulating PKCepsilon-mediated neurite induction. We show an increased association of PKCepsilon to the cytoskeleton during neuronal differentiation. Furthermore, neurite induction by overexpressi
