Filtyp
Charged-particle fragmentation functions for jets azimuthally balanced by a high-transverse-momentum, prompt, isolated photon are measured in 25 pb-1 of pp and 0.49 nb-1 of Pb+Pb collision data at 5.02 TeV per nucleon pair recorded with the ATLAS detector at the Large Hadron Collider. The measurements are compared to predictions of Monte Carlo generators and to measurements of inclusively selected
Assembly of the mitochondrial respiratory chain requires the coordinated synthesis of mitochondrial and nuclear encoded subunits, redox co-factor acquisition, and correct joining of the subunits to form functional complexes. The conserved Cbp3-Cbp6 chaperone complex binds newly synthesized cytochrome b and supports the ordered acquisition of the heme co-factors. Moreover, it functions as a transla
BACKGROUND: Cerebral palsy (CP) is one of the most common early onset disabilities globally. The causative brain damage in CP is nonprogressive, yet secondary conditions develop and worsen over time. Individuals with CP in Sweden and most of the Nordic countries are systematically followed in the national registry and follow-up program entitled the Cerebral Palsy Follow-Up Program (CPUP). CPUP has
Introduction: The objective of this study was to assess the usefulness of the appropriate use criteria (AUC) for amyloid imaging in an unselected cohort. Methods: We calculated sensitivity and specificity of appropriate use (increased confidence and management change), as defined by Amyloid Imaging Taskforce in the AUC, and other clinical utility outcomes. Furthermore, we compared differences in p
BACKGROUND: The Z-curve is a three dimensional representation of DNA sequences proposed over a decade ago and has been extensively applied to sequence segmentation, horizontal gene transfer detection, and sequence analysis. Based on the Z-curve, a "genome order index," was proposed, which is defined as S = a2+ c2+t2+g2, where a, c, t, and g are the nucleotide frequencies of A, C, T, and G, respect
A palliative cancer diagnosis in a parent has a major impact on many aspects of patients’ children. This article aims to explore how doctors and social workers met children as relatives of a parent with cancer in order to understand the possibilities and difficulties in supporting children in specialised palliative homecare in Sweden. Qualitative, semi-structured interviews of doctors and social w
In this paper, NaCl pellets are produced in-house from ordinary household salt using simple and accessible methods, for the purpose of suggesting a cost-effective and available tool for various optically stimulated luminescence dosimetry applications. First, the pellets are investigated in terms of optimal configuration by varying combinations of grain sizes and compression forces. Then, the pelle
Searches for the exclusive decays of the Higgs and Z bosons into a J/ψ, ψ(2S), or ϒ(nS) (n=1,2,3) meson and a photon are performed with a pp collision data sample corresponding to an integrated luminosity of 36.1fb−1 collected at s=13TeV with the ATLAS detector at the CERN Large Hadron Collider. No significant excess of events is observed above the expected backgrounds, and 95% confidence-level up
Despite important applications in unsteady Stokes flow, a Fredholm second kind integral equation formulation modeling the first Dirichlet problem of the modified biharmonic equation in the plane has been derived only recently. Furthermore, this formulation becomes very ill-conditioned when the boundary is not smooth, say, having corners. The present work demonstrates numerically that a method call
The rapid growth of cities requires effective management of transport demand and restructuring of transport systems to address the needs of growing urban populations in an environmentally, socially and economically sustainable way. In recent years, car sharing has emerged as an alternative to owning cars in cities, which has potential to bring environmental gains and address social considerations.
INTRODUCTION: Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identifi
En eftermiddag i juli 2011 besökte jag yrkesfiskaren Nils i hamnen. Vi talade länge om hur han kommit att börja med yrkesfiske och om hans dröm som nyligen blivit verklighet, att sälja fångsten från en egen fiskvagn i hamnen. Han hade även många idéer om hur fisket kunde utvecklas samtidigt som framtidsbilden var dystopisk. I en ekonomi där yrkesfisket har minskat med åttio procent på nittio år, m
Prostate cancer (PCa) is the most common cause of cancer-related death in men after lung cancer. Annually, more than 9000 new cases are diagnosed in Sweden and 2500 of them die each year. Metastatic prostate cancer can be treated with castration. However, the disease eventually recurs within 2 years in more aggressive form and becomes insensitive to castration which is termed as castration resista
Systemic immunization with soluble flagellin (sFliC) from Salmonella Typhimurium induces mucosal responses, offering potential as an adjuvant platform for vaccines. Moreover, this engagement of mucosal immunity is necessary for optimal systemic immunity, demonstrating an interaction between these two semi-autonomous immune systems. Although TLR5 and CD103+CD11b+ cDC2 contribute to this process, th
Localization microscopy methods like Stochastic Optical Reconstruction Microscopy (STORM) are very well suited for exploring clustering of proteins, as the data inherently provide a list of molecular coordinates. Here we use state-of-art cluster analysis algorithms (DBSCAN) to explore the clustering behaviour of different affinity forms of the integrin LFA-1. It has been suggested that LFA-1 may f
An international panel of experts representing 17 European countries and Israel convened to discuss current needs and future developments in BRCA testing and counselling and to issue consensus recommendations. The experts agreed that, with the increasing availability of high-throughput testing platforms and the registration of poly-ADP-ribose-polymerase inhibitors, the need for genetic counselling
Human carbonic anhydrase IX (CA IX) is a multi-domain membrane protein that is therefore difficult to express or crystalize. To prepare crystals that are suitable for neutron studies, we are using only the catalytic domain of CA IX with six surface mutations, named surface variant (SV). The crystallization of CA IX SV, and also partly deuterated CA IX SV, was enabled by the use of microseed matrix
