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Background: Nocturnal hypoxemia commonly affects people with pulmonary fibrosis (PF). Research Question: What are the current practices for assessment of sleep and nocturnal hypoxemia in PF, and what are the research priorities and outcome measures of importance for nocturnal oxygen therapy (NOT)? Study Design and Methods: People with PF and health care professionals (HCPs) with expertise in PF, s
Objective: In the present study, we investigated the role of the gut–liver crosstalk in the pathogenesis of steatotic liver disease (SLD) induced by the compounding and deleterious effects of alcohol and metabolic risk factors, and explored the potential translational aspects of microbiome-based interventions. Design: The effects of combined exposure to alcohol and a high-fat, high-cholesterol die
This study critically explores the launch of the mission for 100 climate neutral cities in Europe. Key elements of the mission are introduced and analysed along with some of its challenges and ambiguities.
Losses of both habitat area and connectivity have been identified as important drivers of species richness declines, but little theoretical and empirical work exists that addresses the effect of fragmentation on relative commonness of highly mobile species such as pollinating insects. With a large dataset of wild bee and butterfly abundances collected across Europe, we first tested the effect of h
Denna uppsats behandlar frågan om mediebilden och tidigare forskning rörande kvinnor och politisk identitet i Afghanistan. Hur presentationen av kvinnorna ser ut och hur deras situation och positionering görs av kvinnor i Afghanistan och hur detta beskrivs i tidningen Dagens Nyheter. Dagens Nyheter är den svenska dagstidning som vi valt ut då vi anser den ha hög validitet och stor läsarkrets. Geno
Ulva rigida is a widely available marine algae representing a valuable biomass from which natural photosensitizers (chlorophylls) can be obtained in an environmentally friendly manner using a green microwave-assisted extraction technique. If properly loaded in biocompatible nanoformulations, such highly hydrophobic chlorophylls with photosensitizing activity may constitute effective drugs useful i
The presence of microplastics (MPs) in water represents a current problem for marine life and a future serious issue for human health. This is pushing towards new approaches for the removal of MPs and, hence, their characterization and evaluation, which up to now has represented a limit for tentative procedures for their degradation. Herein, we reported on a new facile, in situ and non-destructive
When Sweden adopted its carbon tax in 1990, it was as one of the first of its kind worldwide. While the adoption of the tax has been attributed to its inclusion in the Swedish tax reform, undoubtedly playing a crucial role, the reform does not in itself explain how the Swedish carbon tax came about or why it became part of the reform package in the first place. In this article, we present a case s
Direct reprogramming of somatic cells into neurons offers a promising strategy for studying neurological disorders and developing cell-based therapies. This protocol describes the 3D direct reprogramming of human glial progenitor cells into dopaminergic neurons. It includes spheroid formation, lentiviral transduction, neuronal induction using doxycycline, and validation via gene expression and imm
The majority of soil carbon (C) is stored in organic matter associated with reactive minerals. These mineral-organic associations (MOAs) inhibit microbial and enzymatic access to organic matter, suggesting that organic C within MOAs is resistant to decomposition. However, plant roots and rhizosphere microbes are known to transform minerals through dissolution and exchange reactions, implying that
In a world where the challenges of climate change, social inequality, economic instability, and geopolitical tensions are ever-present, educators have a unique opportunity—and responsibility—to prepare their students to navigate these complexities. However, educators are also juggling teaching and research, competing deadlines, shifting expectations, institutional paradigms, and limited time and s
Introduction: Familial risk of lung cancer (LC) is at the level of many common cancers (ca 2.0) but as cigarette smoking is the main cause of LC, it has remained undefined to what extent smoking contributes to the familial risk. We take advantage of the natural experiment of divorce. In Sweden, it has been customary that children stay with their mother after divorce. We thus hypothesize that only
The antibody microarrays have become widespread, but their use for quantitative analyses in clinical samples has not yet been established. We investigated an immunoassay based on nanoporous silicon antibody microarrays for quantification of total prostate-specific-antigen (PSA) in 80 clinical plasma samples, and provide quantitative data from a duplex microarray assay that simultaneously quantifie
Aim: To quantify avian distribution shifts and the extent of niche tracking in response to changing temperature and precipitation patterns. Location: Sweden. Methods: We used abundance monitoring data to quantify changes in bird species distributions between two time periods, 2000-02 and 2010-12. First we examined shifts at the level of whole distributions using population centroids in temperature
Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55
