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This work presents a new mathematical formulation of biologically effective dose (BED) for radiation therapy where effects of repair need to be considered. The formulation is based on the observation that the effects of repair, both during protracted irradiation and of incomplete repair between fractions, can be written using a convolution, i.e. [Formula: see text] where T is the total irradiation
The purpose of this study is to present a new and improved method for translating the electrocardiographic changes of acute myocardial ischemia into a display which reflects the location and extent of the ischemic area and the associated culprit coronary artery. This method could be automated to present a graphic image of the ischemic area in a manner understandable by all levels of caregivers; fr
Hydration free energy calculations are often used to validate molecular simulation methodologies and molecular mechanics force fields. We use the free-energy perturbation method together with the AMOEBA polarizable force field and the Poltype parametrization protocol to predict the hydration free energies of 52 molecules as part of the SAMPL4 blind challenge. For comparison, similar calculations a
Pollinator populations have suffered severe declines in many industrialised countries due to reduced floral and nesting resources, brought on by agricultural intensification. One potential method of mitigating these effects is creating flower strips. Most previous studies have shown higher pollinator abundances in flower strips, but none have been able to demonstrate increased pollinator abundance
Data on the potential effect of obesity and diabetes mellitus on survival after liver resection due to colorectal cancer (CRC) metastases are very limited.
Increasing landscape heterogeneity and organic farming practices are known to enhance species richness in agroecosystems. However, little is known about the consequences of these management options on other biodiversity components such as community composition, phylogenetic structure and functional diversity which may be more closely linked to ecosystem
This Letter presents the first study of W^{±}W^{±}jj, same-electric-charge diboson production in association with two jets, using 20.3 fb^{-1} of proton-proton collision data at sqrt[s]=8 TeV recorded by the ATLAS detector at the Large Hadron Collider. Events with two reconstructed same-charge leptons (e^{±}e^{±}, e^{±}μ^{±}, and μ^{±}μ^{±}) and two or more jets are analyzed. Production cross sect
Mixtures of two cationic proteins were used to prepare protein-DNA gel particles, employing associative phase separation and interfacial diffusion (Moran et al., 2009a). By mixing the two proteins, we have obtained particles that displayed higher loading efficiency and loading capacity values than those obtained in single-protein systems. However, nothing is known about the adverse effects on haem
The aim of this study was to investigate associations between time use in daily activities and sociodemographic and clinical factors in order to identify individuals with persistent mental illness at risk of having an imbalance in daily activities, as reflected in their time use and daily rhythm. Participants (n=103) were selected from a psychiatric outpatient unit using a randomized stratified se
Polymeric anion-exchange membranes (AEMs) are critical components for alkaline membrane fuel cells (AMFCs) which offer several attractive advantages including the use of platinum-free catalysts and a wide choice of fuel. The development of AMFCs and other electrochemical energy systems is currently severely limited by the lack of AEMs with sufficient alkaline stability. Still, significant advances
Agricultural intensification has resulted in large-scale loss of bee pollinators, but while some species have been negatively affected others seem to endure changed conditions. It has been suggested that certain morphological, ecological and life-history traits make some species more vulnerable to landscape changes. Information on which traits make species vulnerable and why may aid conservation o
Designing a system for computer aided diagnosis is a complex procedure requiring an understanding of the biology of the disease, insight into hospital workflow and awareness of available technical solutions. This paper aims to show that a valuable system can be designed for diagnosing kidney lesions in children and adolescents from 99m Tc-DMSA scintigraphy images. We present the chain of analysis
Having historically been abundant throughout Europe, the house sparrow (Passer domesticus) has in recent decades suffered severe population declines in many urban and rural areas. The decline in rural environments is believed to be caused by agricultural intensification, which has resulted in landscape simplification. We used giving-up densities (GUDs) of house sparrows feeding in artificial food
The correlation between real-world clinical decisions and adherence to published treatment algorithms for problem bleeding episodes in patients with severe hemophilia and inhibitors and the resultant impact on clinical outcomes were assessed. Nine cases documenting treatment for problem bleeding episodes in patients with severe hemophilia and inhibitors were retrospectively reviewed. Adherence to
To escape competition at the dung pile, a ball-rolling dung beetle forms a piece of dung into a ball and rolls it away. To ensure an their efficient escape from the dung pile, the beetles rely on a celestial compass to move along a straight paths. Here, we analyzed the reliability of different skylight cues for this compass and found that dung beetles rely not only on the sun, but also on the skyl
Pollination is a key ecosystem service which most often has been studied in isolation although effects of pollination on seed set might depend on, and interact with, other services important for crop production. We tested three competing hypotheses on how insect pollination and pest control might jointly affect seed set: independent, compensatory or synergistic effects. For this, we performed a ca
The anticoagulant vitamin K-dependent protein S (PS) circulates in plasma in two forms, 30% free and 70% being bound to the complement regulatory protein C4b-binding protein (C4BP). The major C4BP isoform consists of 7 alpha-chains and 1 beta-chain (C4BP beta(+)), the chains being linked by disulfide bridges. PS binds to the beta-chain with high affinity. In plasma, PS is in molar excess over C4BP
Hyperthermia is a frequent complication in patients with acute ischemic stroke. On the other hand, therapeutically induced hypothermia has shown promising potential in animal models of focal cerebral ischemia. This Guideline Document presents the European Stroke Organisation guidelines for the management of temperature in patients with acute ischemic stroke.
Understanding, monitoring and mitigating drought is a very difficult task as a consequence of the intrinsic nature of the phenomenon. In addition, assessing the impact of drought on ecosystems and societies is also a complex task, because the same drought severity may have different consequences in different regions and systems due to the underlying vulnerabilities. New technologies based on geosp
To report contemporary outcomes, and evaluate differences after thrombolysis for occluded endoprosthesis, bypasses and native artery occlusion in patients with lower limb ischemia.
