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Background: Optimal alignment is of utmost importance when treating pediatric patients with craniospinal irradiation (CSI), especially with regards to field junctions and multiple isocenters and techniques applying high dose gradients. Here, we investigated the setup errors and uncertainties for pediatric CSI using different setup verification protocols. Methods: A total of 38 pediatric patients t
Modeling criteria interaction in decision-making problems is complex and often neglected. In complicated problems, like contaminated site remediation projects, independency of involved criteria is not a realistic assumption. INfluence based deciSIon guiDE (INSIDE) is a methodology that enables sustainable decision making and management in contaminated site remediation practice. Unlike most previou
We consider thermal fluid structure interaction with a partitioned approach, where typically, a finite volume and a finite element code would be coupled. As a model problem, we consider two coupled Poisson problems with heat conductivities $$\lambda _1$$, $$\lambda _2$$ in one dimension on intervals of length $$l:1$$ and $$l:2$$. Hereby, we consider linear discretizations on arbitrary meshes, such
Autologous hematopoietic stem cell transplantation (AHSCT) to treat multiple sclerosis (MS) has mostly been used in devastating cases as the last option to stop further neurological deterioration. However, evidence from several retrospective clinical trials indicates that young, less disabled patients with highly inflammatory active MS are the most likely to benefit from AHSCT, and after moving fr
Differences in pancreatic islet susceptibility during type 1 diabetes development may be explained by interislet variations. This study aimed to investigate if heterogeneities in vascular support and metabolic activity in rat and human islets may explain why some islets are attacked earlier than other islets. In rats, highly blood perfused islets were identified by injection of microspheres into t
In recent years, quantitative approaches based on mathematical theories and ICT tools, known under the terms of digital, computational, and virtual archaeology, are more and more involved in the traditional archaeological research. In this paper, we apply shape analysis techniques to 3D digital replicas of archaeological findings to support their interpretation. In particular, our study focuses on
Prostate cancer is the second most common cause of cancer-related deaths in men, representing a major source of morbidity and mortality. Androgen deprivation therapy is the primary treatment for patients with advanced prostate cancer at disease presentation, which can be achieved either with surgical or chemical castration. The development of gonadotropin-releasing hormone agonists revolutionized
Background: Depressive symptoms are common in rheumatic diseases and influence patients’ quality of life. The Patient Health Questionnaire-9 (PHQ-9), which assesses symptoms of depression, is valid in English in patients with systemic sclerosis (SSc). However, the measurement properties of the PHQ-8 (short version of the PHQ-9) have not been evaluated in Swedish patients with SSc. Objective: To in
Background: We sought to assess the influence of the clinical introduction of new radiotherapy technologies on glioblastoma patients’ outcomes. Methods: Newly diagnosed glioblastoma patients treated with 60 Gy and temozolomide (2005–2014) were analyzed. The patients’ GTV and CTV were defined based on MR (n = 521) or FET-PET/MR (n = 190), and were treated using conformal radiotherapy (CRT, n = 159)
Background: Recurrence in glioblastoma patients often occur close to the original tumour and indicates that the current treatment is inadequate for local tumour control. In this study, we explored the feasibility of using multi-modality imaging at the time of radiotherapy planning. Specifically, we aimed to identify parameters from pre-treatment PET and MRI with potent
In many financial applications, it is important to classify time-series data without any latency while maintaining persistence in the identified states. The authors propose a greedy online classifier that contemporaneously determines which hidden state a new observation belongs to without the need to parse historical observations and without compromising persistence. Their classifier is based on t
Dijets are produced in abundance at the Large Hadron Collider as predicted by quantum chromodynamics (QCD). However, several theories beyond the Standard Model of Particle Physics predicts new phenomena, which also result in dijet final states. This thesis presents searches for such new phenomena using different techniques. One approach is to look for jets, that originate from top quarks. We know,
A fuel mass estimation method for short pilot diesel injections is proposed and analyzed in this article. Previous studies showed that the pilot misfire ratio was more strongly correlated with the fuel mass than the on-time. This characteristic is exploited for the fuel mass estimation in a region where it is otherwise challenging to get good estimation accuracy due to the low signal-to-noise rati
The sun is the most important energy source for the Earth’s climate system, however, influences of solar variations on climate are not fully understood. Studying past solar activity can improve our understanding of what role the sun plays in Earth’s climate. Cosmogenic radionuclides, such as 10Be in ice cores, are powerful tools to reconstruct past solar activity before the period of direct telesc
Implementation of Bridge weigh-in-motion (B-WIM) measurements and probabilistic approaches in bridge assessment may reveal hidden bridge reserves and changes in reliability levels over their projected service life, providing a key input for optimized bridge management. But, as scientists and engineers and at the same time vendors of our own ideas, we need to be in position to present the results o
Structural Health Monitoring (SHM) has been a subject of major international research in Civil Engineering structures mainly during the last 20 years. While in the beginning, SHM mainly focused on sensor developments, nowadays practical implications regarding the acquisition, collecting and processing of data are being addressed. Indeed, SHM systems have been evolving along the two last decades an
Cross-border regions are characterised by many inherent challenges. Such challenges can include differences in languages, cultures, currencies, markets, labour market conditions, political visions and priorities, governance structures – to name but a few. Greater Copenhagen1 is no different in terms of the challenges it faces as a cross-border region.The aim of this study is to investigate the pos
