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SOX9 is a transcription factor of the SRY family that regulates sex determination, cartilage development and numerous other developmental events. In the foetal growth plate, Sox9 is highly expressed in chondrocytes of the proliferating and prehypertrophic zone but declines abruptly in the hypertrophic zone, suggesting that Sox9 downregulation in hypertrophic chondrocytes might be a necessary step

Objective Comparison of provider performance is commonly used to inform health care decision-making. Little attention has been paid to how data presentations influence decisions. This study analyzes differences in suggested actions by decision-makers informed by league tables or funnel plots.Design Decision-makers were invited to a survey and randomized to compare hospital performance using either

GABA (γ-aminobutyric acid) is the major inhibitory neurotransmitter in the central nervous system, and changes in GABAergic neurotransmission modulate the activity of neuronal networks. Gephyrin is a scaffold protein responsible for the traffic and synaptic anchoring of GABAA receptors (GABAAR); therefore, changes in gephyrin expression and oligomerization may affect the activity of GABAergic syna

The Inner Tracker silicon strip detector (ITk Strip) is a part of the ATLAS upgrade for the HL-LHC. The detector readout and control is accomplished by the interaction of three on-module custom ASICs (ABCStarv1, HCCStarv1 and AMACstar). All ASICs are designed with protections against Single Event Errors. Their resilience at the system-level can be tested using the Board for Evaluation of Triple-ch

Digital technologies have enabled novel forms and reconfigurations of value creation, delivery, and capture. These new reconfigurations challenge the conventional notion of value creation with digital business models. On that premise, the widening of privacy concerns, alert us that organizations of the elite digital, like Netflix, Amazon, and Spotify, design technology to feed on personal data, ba

The goal of this study is to identify the perspectives that development NGOs attribute to organisational social media, and furthermore elaborate on an appropriate categorisation of these perspectives for social media use by development NGOs. How social media is used in the area of development, where the use goes far beyond the private sector purpose of publicity and converting a sale, is a key iss

Background: Voluntary self-exclusion from gambling is a common but underdeveloped harm reduction tool in the management of gambling problems or gambling disorders. Large-scale, multi-operator, and operator-independent self-exclusion services are needed. A recent nationwide multi-operator self-exclusion service in Sweden (Spelpaus), involving both land- and web-based gambling sites, is promising, b

Static analysis tools play a crucial role in software development by detecting bugs and vulnerabilities. However, running these tools separately from the code editing process often causes developers to switch contexts, which can reduce productivity. Previous work has shown how Reference Attribute Grammars (RAGs) can be used for declarative implementation of competitive tooling for intraprocedural

A nonionic lamellar phase was prepared using C10E3 in buffer solution at pH = 7.6. A suitable T4DNA concentration around 5 wt % was immobilized in a lamellar phase with 40 wt % C10E3. The mixed system was investigated at two temperatures, 25 and 5 degrees C by using cryo-fracture TEM direct imaging, fluorescence microscopy and small-angle X-ray scattering. The surprising results where obtained sho

It is expected that, in the future, gas turbines will be operated on gaseous fuels currently unutilized. The ability to predict the range of feasible fuels, and the extent to which existing turbines must be modified to accommodate these fuels, rests on the nature of these fuels in the combustion environment. Understanding the combustion behavior is aided by investigation of syngases of similar com

BACKGROUND AND OBJECTIVES: The treatment of acquired aplastic anemia (AA) is based on allogeneic bone marrow transplantation (BMT) and immunosuppressive therapy. The aim of this study was to assess the outcome of children and adults with AA treated in the last decade, and to determine whether results have improved in two sequential time periods,1991-1996 and 1997-2002. DESIGN AND METHODS: Two-thou

In this paper we propose a scheme for test planning and test access mechanism (TAM) design for stacked integrated circuits (SICs) that are designed in a core-based manner. Our scheme minimizes the test cost, which is given as the weighted sum of the test time and the TAM width. The test cost is evaluated for a test flow that consists of a wafer sort test of each individual chip and a package test

The development of production methods, research on material engineering and analysis tools for energy conversion processes establish a powerful design environment for any unconventional electromagnetic or electromechanical device. The design for manufacturability becomes the one of the main goals of the design apart from cost and performance improvement. The main focus of this paper lies on the de

The development of real-time ultrasound in the 1970's made indelible inpact on antenatal care. Assessing foetal growth and detecting deviations from normal in both growth and foetal anatomy became fesible. Expectant parents could also 'see' their foetus. Normal foetal growth parameters at term were consituted and selected parameters from the second trimester were evaluated in the detection of chro

This article considers recent legal developments on undocumented migrant workers, finds the acceptance of international legal standards unsatisfactory and argues that the private law rights derived from the "semi-legal" employment contract between the employer and the undocumented migrant worker generates a solid base for significant legal claims. It further monitors the promotion of the position