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Denna uppsats undersöker prejudikatens rättskällemässiga status och roll i svensk rätt, samt hur prejudikatens bindande eller vägledande natur ska angripas. Med en rättsdogmatisk metod analyseras hur prejudikat används bland rättskällorna och hur deras auktoritet och funktion varierar beroende på kontext i ett dynamiskt system. Uppsatsen belyser prejudikatens roll som både stabiliserande och utvecThis thesis examines the legal status and role of precedent in Swedish law, as well as how their binding or guiding nature should be approached. Using a legal dogmatic method, the analysis explores how precedents are utilized among legal sources and how their authority and function vary depending on context within a dynamic system. The thesis highlights the dual role of precedents as both stabiliz

Vi vill med den här artikeln peka på att Sveriges städer har flera utmaningar kring styrning och hantering av vatten, samt föreslår sju principer för lösningar. Klimatförändringarna och den urbana tillväxten gör att åtgärder behövs nu för att hantera både vattenbrist och översvämning på ett integrerat sätt. Här fokuserar vi på kommunnivå och urbana områden, där vi argumenterar för att det behövs eWe argue in this paper that Swedish urban areas have several urgent challenges when it comes to water governance and we propose seven principles for addressing them. Climate change and urban growth call for swift action to manage both water scarcity and flooding in an integrated way. This paper focuses on the municipal level for which we argue that there is a need for a more systematic approach. T

This data article presents water stage, flow, and net primary productivity (NPP) data that were used to analyze the dynamics of the riverine dissolved organic carbon (DOC) dynamics in the Rukarara River watershed in Rwanda. We measured water stage data every 15 min and calculated daily averages used to estimate flow based on rating curves. The rating curves were produced using several measured con

After many years of preclinical development, cell and gene therapies have advanced from research tools in the lab to clinical-grade products for patients, and today they constitute more than a quarter of all new Phase I clinical trials for Parkinson's disease. Whereas efficacy has been convincingly proven for many of these products in preclinical models, the field is now entering a new phase where

Introduction: Gender affirming surgery of primary and/or secondary sex characteristics has been shown to alleviate gender dysphoria. A descriptive snapshot of current treatment preferences is useful to understand the needs of the transgender population seeking health care. This study aimed to describe preferences for gender affirming treatment, and their correlates, among individuals seeking healt

IntroductionSport-related concussion (SRC) is a pressing issue in Para sport, yet biomechanical mechanisms remain poorly understood. Athletes with visual impairment face elevated risks due to sport-specific demands, such as frequent collisions in blind football. This pilot study examined head acceleration responses in blind football players compared with non-disabled football players, and between

Episodic memories are formed by hippocampal binding of the "what" and "where" features of everyday events. The hippocampus minimizes interference between related similar episodic memories by pattern separation. Stress and psychopathology are associated with lowered pattern separation. While current behavioral paradigms typically use correct rejections of single object or context lures rather than Episodic memories are formed by hippocampal binding of the "what" and "where" features of everyday events. The hippocampus minimizes interference between related similar episodic memories by pattern separation. Stress and psychopathology are associated with lowered pattern separation. While current behavioral paradigms typically use correct rejections of single object or context lures rather than

Water and salt mass balances for the Dead Sea were modeled. Precipitation, evaporation, river discharges, ground water flows, input/output from potash companies and salt production, and brine discharge were included in the models. The mixing time in the Dead Sea was modeled using a single-layer (well-mixed) atwo-layer (stratified) system.Using the single-layer approach the water level was predicte

Fluid transport in the perivascular space by the glia-lymphatic (glymphatic) system is important for the removal of solutes from the brain parenchyma, including peptides such as amyloid-beta which are implicated in the pathogenesis of Alzheimer’s disease. The glymphatic system is highly active in the sleep state and under the influence of certain of anaesthetics, while it is suppressed in the awak

Filamentous fungi play a key role as decomposers in Earth’s nutrient cycles. In soils, substrates are heterogeneously distributed in microenvironments. Hence, individual hyphae of a mycelium may experience very different environmental conditions simultaneously. In the current work, we investigated how fungi cope with local environmental variations at single-cell level. We developed a method based

Chronic lung diseases (CLDs), such as chronic obstructive pulmonary disease, interstitial lung disease, and lung cancer, are among the leading causes of morbidity globally and impose major health and financial burdens on patients and society. Effective treatments are scarce, and relevant human model systems to effectively study CLD pathomechanisms and thus discover and validate potential new targe

The discovery that the CRISPR/Cas9 system could be used for genome editing purposes represented a major breakthrough in the field. This advancement has notably facilitated the introduction or correction of disease-specific mutations in healthy or disease stem cell lines respectively; therefore, easing disease modeling studies in combination with differentiation protocols. For many years, variabili

Background: Global transcriptional profiling of individual cells represents a powerful approach to systematically survey contributions from cell-specific molecular phenotypes to human disease states but requires tissue-specific protocols. Here we sought to comprehensively evaluate protocols for single cell isolation and transcriptional profiling from heart tissue, focusing particularly on frozen t

CoSAXS is a state-of-the-art SAXS/WAXS beamline exploiting the high brilliance of the MAX IV 3 GeV synchrotron. By coupling advances in sample environment control with fast X-ray detectors, millisecond time-resolved scattering methods can follow structural dynamics of proteins in solution. In the present work, four sample environments are discussed. A sample environment for combined SAXS with UV–v

In this study, we present a systematic investigation of the controlled fabrication of Au-Pd barcode nanowires within nanoporous anodic aluminum oxide (NP-AAO) templates. By using a combination of in situ X-ray diffraction (XRD), focused ion beam scanning electron microscopy (FIB-SEM), and transmission electron microscopy (TEM), we elucidate the influence of template preparation methods on the resu

Objective: Powered mobility offers young children the opportunity to explore their world, develop awareness of their environment, and actively participate in play and daily activities. It enables children with severe disabilities to experience equity and equality by increasing their mobility. Powered mobility devices not only provide means for movement but also enhance children's understanding of

Precision medicine should aspire to reduce error and improve accuracy in medical and health recommendations by comparison with contemporary practice, while maintaining safety and cost-effectiveness. The etiology, clinical manifestation and prognosis of diseases such as obesity, diabetes, cardiovascular disease, kidney disease and fatty liver disease are heterogeneous. Without standardized reportin