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The role of proteins as the mediators of the interaction between engineered materials (biomaterials) and living systems has long been appreciated, but the subtleties and complexities introduced by changing surface curvature are only beginning to be understood. Thus, in implant devices, where the biomaterial is presented as a flat surface, a very limited range of proteins bind to the material, thes

The present invention relates to the use of an ester of inositoltrisphosphate for the preparation of a medicament for preventing, alleviating or combatting inflammatory conditions in mammals including man. Injury or destruction of tissues should be understood as damage to an aggregation of specialized cells with a particular function both internally and externally in the body, such as different or

Neurodegenerative diseases (NDs) affect millions of people worldwide. Characterized by the functional loss and death of neurons, NDs lead to symptoms (dementia and seizures) that affect the daily lives of patients. In spite of extensive research into NDs, the number of approved drugs for their treatment remains limited. There is therefore an urgent need to develop new approaches for the preve

This paper investigates how economic expectations shape voting intentions in a hypothetical independence referendum in Greenland, a self-governing region of the Kingdom of Denmark. I identify the causal effect of economic expectations by randomly exposing respondents to a prime informing on Greenland's current fiscal deficit. Respondents exposed to the information are 43% more likely to oppose ind

The present review discusses the recent developments in the design, fabrication and implementation of mini/micro thermal biosensors for biochemical/clinical analysis and monitoring. The principle of thermometric sensing and recent developments in microfabrication technology are introduced, followed by their adaptation to thermometric devices. The instrumentation of the mini, micro and multisensing

In this article, we propose new tests of equal predictive ability between nested models when factor-augmented regressions are used to forecast. In contrast to the previous literature, the unknown factors are not estimated by principal components but by the common correlated effects (CCE) approach, which employs cross-sectional averages of blocks of variables. This makes for easy interpretation of

Gene fusions have been discussed in the scientific literature since they were first detected in cancer cells in the early 1980s. There is currently no standardized way to denote the genes involved in fusions, but in the majority of publications the gene symbols in question are listed either separated by a hyphen (-) or by a forward slash (/). Both types of designation suffer from important shortco

There has been a strong quest for mapping and assessing ecosystem services (ES) to support governance. Yet, the institutional landscape that governs ES provision across multiple contexts has received less attention. We fill this research gap by developing and operationalising a framework for the analysis of policy documents that address European forest ES provision. By coding and analysing referen

This article discusses how contemporary coaching and laymen therapy can be discussed as modern revival movements well adapted to contemporary individual-centered and therapeutic society. The search for a soul to redeem has been transformed into new religious concepts as searching for the “true inner self”, “the inner potential” or “the authentic me” and new ritualized practices are designed as hel

A novel hybrid nanocomposite adsorbent was prepared by encapsulation of multi-walled carbon nano-tubes within polyvinyl alcohol/chitosan hydrogel (Cs/MWCNT/PVA) and cross-linked with glu-taraldehyde. The chemical reactions between the components affected the position and intensities of the infrared bands. This nanocomposite has excellent Cr6+ ions adsorption efficiency. The optimal conditions of t

We present a mathematical model for the simulation of the development of an outbreak of COVID-19 in a slum area under different interventions. Instead of representing interventions as modulations of the parameters of a free running epidemic we introduce a model structure that accounts for the actions but does not assume the results. The disease is modelled in terms of the progression of viremia re

In this paper we consider the case of planar motion, where a mobile platform equipped with two cameras moves freely on a planar surface. The cameras are assumed to be directed towards the floor, as well as being connected by a rigid body motion, which constrains the relative motion of the cameras and introduces new geometric constraints. In the existing literature, there are several algorithms ava

During the past few decades, intensive research has been focused on the application of biological photosynthetic processes for "green" electrical power generation. In this contribution, we consider different possible photobiocatalysts, such as isolated photosystems, thylakoid membranes (TMs), and whole photosynthetic organisms suitable for building bioelectrochemical systems for light energy conve

Over the last decade, serial crystallography, a method to collect complete diffraction datasets from a large number of microcrystals delivered and exposed to an X-ray beam in random orientations at room temperature, has been successfully implemented at X-ray free-electron lasers and synchrotron radiation facility beamlines. This development relies on a growing variety of sample presentation method

Understanding exposure to air pollution during extreme events such as fire emergencies is critical for assessing their potential health impacts. However, air pollution emergencies often affect places without a network of air quality monitoring and characterising exposure retrospectively is methodologically challenging due to the complex behaviour of smoke and other air pollutants. Here we test the

Considering the widespread contaminations of food products with mycotoxins, it is important to develop, robust, time- and cost-effective detection methods. We developed and optimized an immunoassay using a continuous flow system for the detection of zearalenone (ZEN). The assay was performed in a flow mode using an automated sequential injection system. Time for an assay cycle was 18 Min. Under op

Recently, we reported an association between a SNP in IL28RA and MS. Here, we performed a fine-mapping of the IL28RA locus by genotyping 10 haplotype-tagging SNPs in a Basque-Spanish population. In addition, based on shared genetic risk loci between autoimmune diseases, a psoriasis-associated SNP located at this locus, rs4649203, was genotyped in four independent populations, comprising a total of

Land-use change affects both the quality and quantity of soil organic carbon (SOC) and leads to changes in ecosystem functions such as productivity and environmental regulation. Future changes in SOC are, however, highly uncertain owing to its heterogeneity and complexity. In this study, we analyzed the outputs of simulations of SOC stock by Earth system models (ESMs), most of which are participan