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Risk factors for breast cancer vary according to breast cancer subtype. This study analyzes the impact of potential risk factors in breast cancer by androgen receptor (AR) status.
Ebf1 is a transcription factor with documented dose dependent functions in normal and malignant B-lymphocyte development. To understand more about the roles of Ebf1 in malignant transformation, we investigated the impact of reduced functional Ebf1 dosage on mouse B-cell progenitors. Gene expression analysis suggested that Ebf1 was involved in the regulation of genes important for DNA repair as wel
. Zia E, Melander O, Bjorkbacka H, Hedblad B, Engstrom G (Lund University, Malmo; Institute of Clinical Sciences, Lund University, Malmo; Skane University Hospital, Malmo; and Astra Zeneca R&D, Malmo, Sweden). Total and differential leucocyte counts in relation to incidence of stroke subtypes and mortality: a prospective cohort study. J Intern Med 2012; 272: 298304. Objectives. Elevated levels
Hypoxia, or low oxygen tension, is a major regulator of tumor development and aggressiveness. However, how cancer cells adapt to hypoxia and communicate with their surrounding microenvironment during tumor development remain important questions. Here, we show that secreted vesicles with exosome characteristics mediate hypoxia-dependent intercellular signaling of the highly malignant brain tumor gl
BACKGROUND: We previously reported that a single prostate-specific antigen (PSA) measured at ages 44-50 was highly predictive of subsequent prostate cancer diagnosis in an unscreened population. Here we report an additional 7 years of follow-up. This provides replication using an independent data set and allows estimates of the association between early PSA and subsequent advanced cancer (clinical
OBJECTIVES: To determine whether a long-term treatment with beta-blockers influences the inflammatory activity in carotid artery disease by reducing the carotid plaque levels of lipoprotein-associated phospholipase A2 (Lp-PLA2), its enzymatic products lysophosphatidylcholine (lysoPCs), and of soluble urokinase plasminogen activator receptor (suPAR). MATERIALS AND METHODS: One hundred and thirty-fo
Background. Sunlight exposure and fair skin are major determinants of human vitamin D production, but they are also risk factors for cutaneous malignant melanoma (MM). There is epidemiological evidence that all-cause mortality is related to low vitamin D levels. Methods. We assessed the avoidance of sun exposure as a risk factor for all-cause mortality for 29 518 Swedish women in a prospective 20-
Genetic predisposition for cardiovascular disease (CVD) is likely to be modified by environmental exposures. We tested if the associated risk of CVD and CVD-mortality by the single nucleotide polymorphism rs4977574 on chromosome 9p21 is modified by life-style factors.
Community screening to guide preventive interventions for acute aortic disease has been recommended in high-risk individuals. We sought to prospectively assess risk factors in the general population for aortic dissection (AD) and severe aneurysmal disease in the thoracic and abdominal aorta.
The DEK gene is highly expressed in a wide range of cancer cells, and a recurrent translocation partner in acute myeloid leukemia. While DEK has been identified as one of the most abundant proteins in human chromatin, its function and binding properties are not fully understood.
Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is imperfect for predicting outcome, which results in overtreatment for many patients, and for others, leads to death from recurrent disease. Therefore, additional criteria are needed to better personalize care and maximize treatment effectiveness and survival.
Popular Abstract in Swedish Avhandlingens ämne är den mezuzah, en kapsel med texter ur 5 Mosebok, som bör fästas på dörrposterna i ett judiskt hem, i uppfyllande av budet i 5 Mos. 6:9/11:21: "och du skall skriva dem [dessa ord] på dörrposterna i ditt hus och på dina portar". Genom en översikt över rabbinska texter vilka behandlar budet att fästa en mezuzah på dörrposterna i hemmet inThe present study deals with different aspects of the mitsvat mezuzah in Rabbinic literature from the first to the sixteenth centuries, with some emphasis on the medieval sources. Through a charting of statements regarding the mezuzah as an object, and the mitsvat mezuzah and its fulfilment, an overview is given of the development of the mezuzah and the perception of it
Preeclampsia (PE) is a serious pregnancy complication that manifests as hypertension and proteinuria after the 20(th) gestation week. Previously, fetal hemoglobin (HbF) has been identified as a plausible causative factor. Cell-free Hb and its degradation products are known to cause oxidative stress and tissue damage, typical of the PE placenta. A1M (α1-microglobulin) is an endogenous scavenger of
Abstract not available
The Gospels record that Jesus purported to forgive sins. What significance would such a claim have had for his contemporaries and what would the implications have been for his identity as a first-century popular prophet? Tobias Hägerland answers these questions and more as he investigates the forgiveness of sins in the mission of the historical Jesus. The Gospels are interpreted within the context
The paper examines the metaphysical ideas employed to embed Hellenistic astrology in an Indian religious and cultural context, relating them to questions of causality, determinism and moral freedom. These ideas are contrasted against the largely Thesophical adaptation of the same concepts, which in the 19th and 20th centuries formed the emerging modern astrology in Europe, and which led it to aban
