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Aim: To investigate whether there is any pharmacokinetic rationale for the common practice of administering vincristine to adolescents at relatively lower doses than those to younger children. Methods: A total of 98 children, aged 1.3-17.3 y, with acute lymphoblastic leukaemia (ALL) were studied on day I of induction therapy. Plasma samples were drawn before and 10, 30, 360 and 1380 min after inje
The application of the protein and polysaccharide fractions of barley spent grain as a basis of growth media for probiotic bacteria was studied. High values of biomass yield, cell viability, and organic acid production were observed in the variants of media containing the barley spent grain supplemented with lactose, ascorbic acid, yeast extract, and mineral salts. Cells of lactic acid bacteria an
Neuroinformatics is the information science infrastructure of neuroscience. It relates to the tools, databases, models and mechanisms of information flow that serve all of the clinical and research efforts in this field. There have been several attempts to create neuroinformatic systems, but none seem to have reached wide spread adoption yet. This is especially true in the in the area of cognitive
Head injuries in sports have received increased attention during the past decade. As explained in this article, the most recent guidelines for the management of head injuries in sports adopted by the American Academy of Neurology (AAN) have been adapted for the Swedish sports society. The guidelines include a grading scale of head injuries in sports, a sideline evaluation to aid physicians, coache
BACKGROUND: The importance of tobacco smoking and Helicobacter pylori infection as risk factors in the development of gastric carcinoma was investigated through multivariate conditional logistic regression analysis in a nested case-control study. METHODS: Blood samples and a questionnaire on smoking habits were collected from a cohort of 32,906 city residents during a health screening programme fr
A total of 42 Swedish patients with biopsy-proven chronic hepatitis C virus (HCV) infection were treated with a natural human leucocyte alpha-interferon (HuIFN-alpha-Le), Alfanative (BioNative AB, Umeå, Sweden) in an open uncontrolled study. Two patients were withdrawn from treatment within 2 weeks due to non-compliance and were omitted from further analysis, and 40 patients (17 females), mean age
Digitonin, which is known to cause extensive damage to cytomembranes in general, was found to have a most remarkable effect on epidermal Langerhans' cells. Thus, it generates a membrane-sandwiching process resulting in the formation of large discs which except for the differences in size have the same morphology as ordinary Birbeck granules. This demonstrates that the cytomembrane of the Langerhan
We present an algorithm for the inverse scattering problem associated to a nonlinear equation arising in the study of the unidirectional propagation of waves in shallow water.
The scalar polarizability constanta0 for excitedS- andD-states in rubidium and cesium was measured utilizing a two-step excitation scheme. An rf lamp and a single-mode dye laser were used to excite the atoms in a collimated atomic beam. Values ofa0 were determined for the 9–102S1/2 and 7–82D3/2 states of rubidium and for the 10–132S1/2, 9–102D3/2 and 9–112D5/2 states of cesium. Further, the isotop
Sulfation of all macromolecules entering the secretory pathway in higher organisms occurs in the Golgi and requires the high-energy sulfate donor adenosine 3'-phosphate 5'-phosphosulfate. Here we report the first molecular identification of a gene that encodes a transmembrane protein required to transport adenosine 3'-phosphate 5'-phosphosulfate from the cytosol into the Golgi lumen. Mutations in
Mutagenic/carcinogenic heterocyclic amines (HAs) are formed at low levels (ng/g) during heat processing of protein-rich food such as meat and fish. The complex matrix requires effective extraction and purification methods. Blue Chitin columns were used for the extraction of HAs from fried chicken fillets and the samples were analysed with LC-MS. Several HAs were identified at levels ranging from 0
The performance of a turbo code can be severely degraded if no trellis termination is employed. This paper investigates the implications of the choice of trellis termination method for turbo codes, and explains the origin of the performance degradation often experienced without trellis termination. An efficient method to derive the distance spectrum of turbo codes for different trellis termination
A selective pressurized liquid extraction (SPLE) procedure capable of performing simultaneous extraction and clean-up has been demonstrated for multi-residue analysis of organochlorine pesticides (OCPs) in soil. The final method was performed at 100 degrees C for 3 x 10 min using acetone/n-heptane (1:1, v/v). Florisil was placed inside the extraction cell downstream the sample to remove interferin
