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Advances in super-resolution microscopy enable the molecular profiling of cells and tissues at the nanoscale level, surpassing the diffraction limit of conventional light microscopy. However, super-resolution techniques typically require access to expensive specialized equipment and extensive training, limiting their broad applicability. Here we provide a detailed protocol for combining expansion

The macroscopic response governed by a statistical volume element, generated from 3D X-ray computer tomography images of paperboard, is explored. The statistical volume element, which consists of fibres and void, is derived from X-ray computer tomography images. Two filters for computing intensity fields and intensity gradients have been implemented and compared. Using an intensity threshold, the

This book provides a highly accessible and user-friendly overview of the essential concepts and terms related to the current global endeavour to implement the Sustainable Development Goals.With the first decade of the 15-year timespan of the 2030 Agenda now past, the SDGs show limited progress and several goals are even regressing. It is imperative that SDG implementation is accelerated until 2030

Urbanisation, lifestyles and environmental degradation are associated with negative health and environmental outcomes through reducing greenspace access. These risks are not experienced equally across society. While useful concepts like ‘extinction of experience’ exist, sociological writing on these important themes remains underdeveloped. Using regression and analysis of variance with survey data

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the benefits and harms of pain and sedation management for screening or treatment of retinopathy of prematurity in preterm infants compared to placebo, no intervention, or other interventions.

This paper describes the development of a new variant of stereoselective strain-release driven reactions (formal homo [3 + 2] dipolar cycloadditions) which utilize housane (1) to construct functionalized amino alcohols and pyridine-substituted cyclopentanes in two to three steps from simple and easily available building blocks (nitrones and pyridine N-oxides respectively).

Vowel-based voice analysis is gaining attention as a potential non-invasive tool for COPD classification, offering insights into phonatory function. The growing need for voice data has necessitated the adoption of various techniques, including segmentation, to augment existing datasets for training comprehensive Machine Learning (ML) modelsThis study aims to investigate the possible effects of seg

Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To evaluate the benefits and harms of using NGS techniques compared to conventional newborn screening alone for pre-symptomatic identification of genetic diseases in newborns. Secondary objectives: to explore equity and ethical issues in the application of the new techniques, to inform healthcare d

Human-robot interactions are inherently different from interactions with other artefacts, as robots are autonomous. Furthermore, recent technological advances have also enabled robots to undertake roles that are formerly thought to be reserved for humans, e.g. as companions or lovers, since interactive abilities of robots and their autonomy are sufficient to evoke an automatic cognitive response -

This paper constructs the first long-run estimates of Irish regional GDP over the twentieth century and traces the relative economic performance of Ireland’s regions since independence. Using an array of data sources available at a county level, output in Agriculture, Industry and Services in benchmark census years is estimated. Applying a variety of alternative measures, we find a reduction in re

How does new technology impact labor market outcomes? We address this question by examining the adoption of electricity in Sweden during the early 20th century. Leveraging detailed individual-level data that covers the entire labor market and exogenous variation in electricity access driven by proximity to hydro-power plants, we estimate the impact of electrification on individual labor market out

Sedimentary concentrations of redox-sensitive trace metals are widely used to reconstruct past ocean redox conditions. Vanadium (V) has great potential as a (paleo)redox proxy, due to its strong redox-dependent speciation (+III, +IV, +V) and the increased sedimentary sequestration of its more reduced species. The geochemistry of V in sulfide-rich marine environments is not yet well understood, how

Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional s

Micro-scale mechanisms, such as inter-particle and particle-fluid interactions, govern the behaviour of granular systems. While particle-scale simulations provide detailed insights into these interactions, their computational cost is often prohibitive. At a recent Lorentz Center Workshop on “Machine Learning for Discrete Granular Media”, researchers explored how machine learning approaches can aid

This paper examines the track record of private financial mechanisms aimed at funding conservation of biological diversity. It finds that, due to lack of rigorous and consistent benchmarks and monitoring, these investments may not necessarily safeguard biodiversity and could even, in some cases, have adverse impacts. Further, despite decades of attempts to draw private capital to biodiversity prot