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The Grodsky packet storage model describes many features of insulin release, but at present more or less arbitrary simplifications are necessary. The consequences of various simplifications are discussed, especially with regard to identification of parameters thought to be of importance for glucose tolerance. In particular, the insulin release dynamics of the ordinary intravenous glucose tolerance
Inferential Role Semantics is often criticized for being incompatible with the platitude that words of different speakers can mean the same thing. While many assume that this platitude can be accommodated by understanding sameness of meaning in terms of similarity of meaning, no worked out proposal has ever been produced for Inferential Role Semantics. I rectify this important omission by giving a
We consider the problem of identifying structural influences of external inputs on steady-state outputs in a biological network model. We speak of a structural influence if, upon a perturbation due to a constant input, the ensuing variation of the steady-state output value has the same sign as the input (positive influence), the opposite sign (negative influence), or is zero (perfect adaptation),
This paper addresses set invariance properties for linear time-delay systems. More precisely, the first goal of the article is to review known necessary and/or sufficient conditions for the existence of invariant sets with respect to dynamical systems described by linear discrete time-delay difference equations (dDDEs). Secondly, we address the construction of invariant sets in the original state
Over 50 million people worldwide have epilepsy. In nearly 30% of these cases, epilepsy remains unsatisfactorily controlled despite the availability of over 20 antiepileptic drugs. Moreover, no treatments exist to prevent the development of epilepsy in those at risk, despite an increasing understanding of the underlying molecular and cellular pathways. One of the major factors that have impeded rap
We show that the two problems of computing the permanent of an n*n matrix of poly(n)-bit integers and counting the number of Hamiltonian cycles in a directed n-vertex multigraph with exp(poly(n)) edges can be reduced to relatively few smaller instances of themselves. In effect we derive the first deterministic algorithms for these two problems that run in o(2^n) time in the worst case. Classic pol
Hur stor bör den svenska statsskulden vara? I dag finns en livlig debatt kring frågan, knuten till överskottsmålets vara eller inte vara. Den ekonomiska litteraturen ger inget klart svar. Storleken på den ”optimala” eller lämpliga statsskulden beror på både vilken teori eller riktlinje som är utgångspunkten och vilken empirisk metod som används. Vi argumenterar för att statsskulden mätt som Maast
Second-generation ethanol from lignocellulose is a sustainable alternative that can partially replace fossil fuels. To be competitive with first generation ethanol from sugar and starch crops and fossil fuels, the conversion efficiency and ethanol yields of second-generation ethanol conversion processes must be improved. Improving the performance of the fermenting microorganism and efficiently con
The question of whether proteins originate from random sequences of amino acids is addressed. A statistical analysis is performed in terms of blocked and random walk values formed by binary hydrophobic assignments of the amino acids along the protein chains. Theoretical expectations of these variables from random distributions of hydrophobicities are compared with those obtained from functional pr
We present a QCD-based model where rescattering between final state partons in deep inelastic scattering leads to events with large rapidity gaps and a leading proton. In the framework of this model the amplitude for multiple gluon exchanges is calculated in the eikonal approximation to all orders in perturbation theory. Both large and small invariant mass MX limits are considered. The model succe
We consider the problem of localizing a novel image in a large 3D model, given that the gravitational vector is known. In principle, this is just an instance of camera pose estimation, but the scale of the problem introduces some interesting challenges. Most importantly, it makes the correspondence problem very difficult so there will often be a significant number of outliers to handle. To tackle
In this article, the 2009 European League Against Rheumatism (EULAR) recommendations for the management of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) have been updated. The 2009 recommendations were on the management of primary small and medium vessel vasculitis. The 2015 update has been developed by an international task force representing EULAR, the European Renal Ass
Silicon photomultipliers (SiPMs) are an enabling solid-state technology for low light sensing, with single photon sensitivity and photon number resolving capability. They feature an extremely high internal gain at the 106 level, comparable to photomultiplier tubes (PMTs), with the advantage of low operating voltage (~50 V compared to ~1000 V for PMT) and low energy consumption. The solid-state tec
A Keyless Signing Infrastructure (KSI) provides users with a means to timestamp documents on a per-second basis. The KSI consists of a global infrastructure with several server layers and by using Merkle hash trees, the root hash can be used to verify the integrity and timestamp of a document. Regular publication of root hashes, e.g., once per month, allows a document to be verified without suppor
An electron injector for multi-stage laser wakefield experiments is presented. It consists of a variable length gas cell of small longitudinal dimension (⩽10mm). The gas filling process in this cell was characterized both experimentally and with fluid simulation. Electron acceleration experiments were performed at two different laser facilities. Results show low divergence and low pointing fluctua
