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In the past decade, many initiatives were taken for the development of antibodies for proteome-wide studies, as well as characterisation and validation of clinically relevant disease biomarkers. Phage display offers many advantages compared to antibody generation by immunisation because it is an unlimited resource of affinity reagents without batch-to-batch variation and is also amendable for high
Hollow structures on the submicrometer scale (urn) are obtained with the assembly of polyelectrolytes according to the layer-by-layer (LbL) technique. Following the LbL procedure, polymers alginate and chitosan were alternatively adsorbed on a vesicular template made of didodecyldimethylammonium bromide (DDAB). Evidence for the removal of the vesicular template entrapped in the alginate/chitosan f
A framework for accurately modeling fatigue crack growth in ductile crystalline solids is necessarily multiscale The creation of new free surface occurs at the atomistic scale, where the material's cohesive strength is controlled by the local chemistry On the other hand, significant dissipation during fatigue crack growth takes place at a size scale that can be modeled appropriately by conventiona
In this paper, I evaluate the usefulness of protein homology models in rigorous free-energy simulations to determine ligand affinities. Two templates were used to create models of the factor Xa protein and one template was used for dihydrofolate reductase from Plasmodium falciparum. Then, the relative free energies for several pairs of ligands were estimated using thermodynamic integration with th
The open XML format mzML, used for representation of mass spectrometry (MS) data, is pivotal for the development of platform-independent MS analysis software. Although conversion from vendor formats to mzML must take place on a platform on which the vendor libraries are available (i.e. Windows), once mzML files have been generated, they can be used on any platform. However, the mzML format has tur
The multicanonical, or flat-histogram, method is a common technique to improve the sampling efficiency of molecular simulations. The idea is that free-energy barriers in a simulation can be removed by simulating from a distribution where all values of a reaction coordinate are equally likely, and subsequently reweight the obtained statistics to recover the Boltzmann distribution at the temperature
Under det senaste decenniet har en rad kvinnliga författare kommit att bli framgångsrika inom den svenska deckargenren. Det vanliga epitetet ”deckardrottning” vittnar om att framgången står i relation till en offentlig och medialiserad version av författarskapen, där den kvinnliga erfarenheten spelar en betydande roll. Liza Marklund och Camilla Läckberg är de två bland dessa författarskap som skap
The objective of the international Chromosome-Centric Human Proteome Project (C-HPP) is to map and annotate all proteins encoded by the genes on each human chromosome. The C-FIPP consortium was established to organize a collaborative network among the research teams responsible for protein mapping of individual chromosomes and to identify compelling biological and genetic mechanisms influencing co
This article addresses two problems characterizing policy thinking on environmental change and sustainable development. First, the role of the social sciences in the wider processes of governance is sometimes misrepresented such that the likelihood of achieving consensual decision-making on environmental phenomena is overestimated. Second, the social science discourse on governance is plagued by c
When the moon is absent from the night sky, stars remain as celestial visual cues. Nonetheless, only birds [1, 2], seals [3], and humans [4] are known to use stars for orientation. African ball-rolling dung beetles exploit the sun, the moon, and the celestial polarization pattern to move along straight paths, away from the intense competition at the dung pile [5-9]. Even on clear moonless nights,
Single-carrier frequency division multiple access (SC-FDMA) is considered as a promising technique that is adopted in the uplink for the upcoming 3GPP long term evolution (LTE). This is because it keeps most of the advantages of OFDMA in addition to low peak to average power ratio (PAPR). Designing diversity achieving schemes for SC-FDMA is a challenging task. The code should not affect the PAPR a
Cellulose nanofibrils were produced from P. radiata kraft pulp fibers. The nanofibrillation was facilitated by applying 2,2,6,6-tetramethylpiperidinyl-1-oxyl-mediated oxidation as pretreatment. The oxidized nanofibrils were cross-linked with polyethyleneimine and poly N-isopropylacrylamide-co-allylamine-co-methylenebisacrylamide particles and were frozen to form cryo-structured gels. Samples of th
Pervasive middleware systems are important for enabling the configuration and coordination of the services provided by devices in pervasive environments. PalCom is an example of such a system that aims to enable interaction among pervasive services over heterogeneous networks. In this paper we discuss the need for providing networking-media independent messaging among pervasive devices, and identi
This article presents an architecture of a Digital Front-End Receiver (DFE-Rx) for the next-generation mobile terminals. A main focus is placed in flexibility, scalability and concurrency. The architecture is capable of detecting, synchronizing and reporting carrier-frequency offset, of multiple concurrent radio standards. The proposed receiver is fabricated in a 65nm CMOS low power high-VT cell t
The rapid development of wireless sensor network and RFID technologies offers a wide range of novel applications and services. In this paper, we present a two-layered wireless network for warehouses and supermarkets to monitor goods storage and sale, and assist for quality management and market analysis. The hierarchical architecture uses IEEE 802.15.4a impulse ultra-wideband radio (IR-UWB) commun
Rapporten behandlar inledningsvis frågan vad en kris är, hur den uppstår, när den uppstår och varför. Kapitlet behandlar också frågan om när det vänder och varför det vänder. I kapitlet framförs kritik mot det etablerade synsättet inom ortodox nationalekonomi som starkt bidrar till att kriser inte kan förutses och att feltolkningar av det ekonomiska läget görs. I nästkommande kapitel behandlas tv
