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Mode of first delivery and severe maternal complications in the subsequent pregnancy

Introduction: Severe obstetric complications increase with the number of previous cesarean deliveries. In the Nordic countries most women have two children. We present the risk of severe obstetric complications at the delivery following a first elective or emergency cesarean and the risk by intended mode of second delivery. Material and methods: A two-year population-based data collection of sever

Intermediate and advanced topics in multilevel logistic regression analysis

Multilevel data occur frequently in health services, population and public health, and epidemiologic research. In such research, binary outcomes are common. Multilevel logistic regression models allow one to account for the clustering of subjects within clusters of higher-level units when estimating the effect of subject and cluster characteristics on subject outcomes. A search of the PubMed datab

Revisiting the discriminatory accuracy of traditional risk factors in preeclampsia screening

BACKGROUND: Preeclampsia (PE) is associated with a high risk of perinatal morbidity and mortality. However, there is no consensus in the definition of high-risk women.AIM: To question current definition of high PE risk and propose a definition that considers individual heterogeneity to improves risk classification.METHODS: A stratified analysis by parity was conducted using the Swedish Birth Regis

Perinatal outcomes after treatment with ADHD medication during pregnancy

OBJECTIVES: To analyze perinatal outcomes after maternal use of attention-deficit/ hyperactivity disorder (ADHD) medication during pregnancy. METHODS: The study included singletons born between 2006 and 2014 in Sweden. Data on prescription drug use, pregnancies, deliveries, and the newborn infants' health were obtained from the Swedish Medical Birth Register, the Prescribed Drug Register, and the

The role of the clinical departments for understanding patient heterogeneity in one-year mortality after a diagnosis of heart failure : A multilevel analysis of individual heterogeneity for profiling provider outcomes

PURPOSE: To evaluate the general contextual effect (GCE) of the hospital department on one-year mortality in Swedish and Danish patients with heart failure (HF) by applying a multilevel analysis of individual heterogeneity.METHODS: Using the Swedish patient register, we obtained data on 36,943 patients who were 45-80 years old and admitted for HF to the hospital between 2007 and 2009. From the Dan

CELSR2 is a candidate susceptibility gene in idiopathic scoliosis

A Swedish pedigree with an autosomal dominant inheritance of idiopathic scoliosis was initially studied by genetic linkage analysis, prioritising genomic regions for further analysis. This revealed a locus on chromosome 1 with a putative risk haplotype shared by all affected individuals. Two affected individuals were subsequently exome-sequenced, identifying a rare, non-synonymous variant in the C

Long-term effects of daily physical education throughout compulsory school on duration of physical activity in young adulthood : An 11-year prospective controlled study

Objectives We examined whether daily physical activity (PA) during compulsory school encourages children to be more physically active during the intervention and 4 years after termination of the programme. Methods This prospective controlled intervention study followed the same 124 children (81 children in an intervention group and 43 controls) aged 7.7±0.6 (mean±SD) during a 7-year PA interventio

Effects of Kidney Transplantation on Labor Market Outcomes in Sweden

Background: Kidney transplantation is considered a superior treatment for end-stage renal disease compared with dialysis although little is known about the wider effects, especially on labor market outcomes. The objective is to estimate the treatment effect of kidney transplantation compared with dialysis on labor market outcomes, controlling for the nonrandom selection into treatment. Methods: Th

Prevalence of Voice Disorders in the General Population, Based on the Stockholm Public Health Cohort

Objective: To investigate the prevalence of voice disorders in the general population. Study design: Analysis of data from the Stockholm Public Health Cohort. Methods: A public health survey was distributed to an open cohort of 114,538 adults >18 years of age in the area of Stockholm County, Sweden. The survey included one question about voice problems, estimating the extent of occurrence of voice

Diagnosis and management of bone fragility in diabetes : an emerging challenge

Fragility fractures are increasingly recognized as a complication of both type 1 and type 2 diabetes, with fracture risk that increases with disease duration and poor glycemic control. Yet the identification and management of fracture risk in these patients remains challenging. This review explores the clinical characteristics of bone fragility in adults with diabetes and highlights recent studies

The importance of enteral nutrition

Many neurological diseases are followed by a disturbance of nutritional intake to some extent and thus constitute the most common indication for nutritional support and enteral access. Several studies have shown that malnutrition is a common condition, with as many as 40% of admitted patients being identified as undernourished and 78% of these further found to be deteriorated in their nutritional

Disability and Pain are the Best Predictors of Sick Leave After a Distal Radius Fracture in Men

Purpose Distal radius fracture often compromises working ability, but clinical implications are less studied in men due to its lower incidence. This study therefore describes sick leave in men with distal radius fracture, specifically exploring the impact of patient- and fracture-related factors. Methods Professionally active men aged 20–65 with distal radius fracture were followed prospectively f

Risk of major osteoporotic fracture after first, second and third fracture in Swedish women aged 50 years and older

Background: Osteoporosis affects approximately one in five European women and leads to fragility fractures, which result in poor health, social and economic consequences. Fragility fractures are a strong risk factor for subsequent major osteoporotic fracture (MOF), with risk of MOF being elevated in the 1–2 years following an earlier fracture, a concept described as “imminent risk”. This study exa

HIV-1 Transmission Patterns Within and Between Risk Groups in Coastal Kenya

HIV-1 transmission patterns within and between populations at different risk of HIV-1 acquisition in Kenya are not well understood. We investigated HIV-1 transmission networks in men who have sex with men (MSM), injecting drug users (IDU), female sex workers (FSW) and heterosexuals (HET) in coastal Kenya. We used maximum-likelihood and Bayesian phylogenetics to analyse new (N = 163) and previously

On neural network modeling to maximize the power output of PEMFCs

Optimum operating conditions of a fuel cell will provide its maximum efficiency and the operating cost will be minimized. Thus, operation optimization of the fuel cell is essential. Neural networks can simulate systems without using simplifying assumptions. Therefore, the neural network can be used to simulate complex systems. This paper investigates the effects of important parameters, i.e., temp

Effect and optimization of backward hole parameters on film cooling performance by Taguchi method

In recent years, increasing inlet temperature of gas turbines has far exceeded the melting point of the metal materials. Film cooling technology has widely been used to protect gas turbine blades from erosion of the high-temperature gases. The film cooling performance can be improved by optimization of the hole configurations. Results show that the backward injection hole has a smaller exit moment

Exercise and Peak Bone Mass

Purpose of review: The main goal of this narrative review is to assess whether physical activity (PA) influences peak bone mass and fracture risk. Recent findings: Several randomized controlled trials (RCT) show that short-term PA intervention programs in childhood improve the accrual of bone mineral. There are now also long-term controlled PA intervention studies demonstrating that both boys and

Disentangling the contribution of hospitals and municipalities for understanding patient level differences in one-year mortality risk after hip-fracture : A cross-classified multilevel analysis in Sweden

BACKGROUND: One-year mortality after hip-fracture is a widely used outcome measure when comparing hospital care performance. However, traditional analyses do not explicitly consider the referral of patients to municipality care after just a few days of hospitalization. Furthermore, traditional analyses investigates hospital (or municipality) variation in patient outcomes in isolation rather than a

Climate impact on the durability of asphalt concrete

Roads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the boRoads are subjected to traffic loads and varying climate conditions that eventually lead to different types of damage. Moisture in asphalt is one of the major causes of premature failure in asphalt pavements. In addition, moisture in the unbound layers and temperature in the asphalt concrete (AC) layers affect the structural response of pavements under loading, such as the tensile strain at the bo

Numerical study of heat transfer in gravity-driven particle flow around tubes with different shapes

In the present paper, the heat transfer of gravity-driven dense particle flow around five different shapes of tubes is numerically studied using discrete element method (DEM). The velocity vector, particle contact number, particle contact time and heat transfer coefficient of particle flow at different particle zones around the tube are carefully analyzed. The results show that the effect of tube