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Gene amplification is one of the mechanisms for oncogene activation in solid tumors. The size of the amplified regions may vary considerably among individual tumors, and more than one gene may be affected within the same amplicon. The main objective in analyzing genomic amplifications has therefore been to map the shortest region involved and to identify genes with increased expression as a result
Critical IS research agendas are more important than ever if we wish to uncover the unanticipated and potentially harmful consequences of digital technologies. Developed from Michel Foucault’s late work, we introduce the problematization lens as a critical IS research strategy for exploring discursive commitments embedded in digital phenomena. The problematization lens is characterized by a geneal
Sustainability is an increasingly important topic across the world, and awareness of it has been growing since the publication of the UN sustainable development goals (SDGs). Seeing an escalating societal interest in sustainability, consumer demand for sustainable products in retailer’s assortments. Making the retail store manager a key player for implementing Corporate Social Responsibility (CSR)
A number of specific chromosomal abnormalities define the subgroups of multiple myeloma. In a meta-analysis of two genome-wide association studies of multiple myeloma including a total of 1,661 affected individuals, we investigated risk for developing a specific tumor karyotype. The t(11;14)(q13;q32) translocation in which CCND1 is placed under the control of the immunoglobulin heavy chain enhance
The article investigates social learning of doping among elite athletes, based on qualitative interviews with 10 former competitive powerlifters, which were analyzed with Lave and Wenger’s learning theories. The constitution of the social context–the sports community–and specific situations were decisive for how the informants acted in relation to doping. The informants were situated in a powerlif
Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg
In the field of quantum optics and its wide variety of applications it is essential to have high brightness sources of entangled photons. In this Bachelor project, the aim has been to produce such a source based on recent experimental setups [1] [2] with a so-called Sagnac interferometer to generate polarization-entangled photons. The source built shows high quality entanglement. High visibility p
The PPM (Prediction by Partial Matching) family of text compression algorithms has several members that have shown to be very efficient in practice. This thesis treats PPM algorithms from an information-theoretical point of view, based on results and methods from universal source coding theory. A number of source classes for modeling text-like data are developed, that are distinguished both by st
A proposal for a new synchrotron light source, MAX 4, is presented. The main components are two identical storage rings operated at different electron beam energies and equipped with superconducting insertion devices. Small beam emittances will yield high brilliance radiation over a wide spectral range. A small horizontal emittance is achieved by using a large number of cells with gradient dipoles
Modelica is a modelling language used to describe a physical system and can be used to simulate the system. A Modelica compiler transforms a Modelica model into an equation system in order to simulate it. During this transformation the information about where the equations originates from is lost. This information could be useful to have when, e.g., trying to locate an error. In this thesis we sol
This study discovers how the microentrepreneurs running water refill stations (WRSs) assess the income generation potential of drinking water sale in Jakarta including the motivations to start up and sustain the business as well as the challenges they face with in the water market. The study further provides insights on the broader externalities to which WRSs have contributed. The design of the re
Languages of diverse structures and different families tend to share common patterns if they are spoken in geographic proximity. This convergence is often explained by horizontal diffusibility, which is typically ascribed to language contact. In such a scenario, speakers of two or more languages interact and influence each other’s languages, and in this interaction, more grammaticalized features t
