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https://www.medicin.lu.se/evenemang/protein-production-sweden-malin-backstrom-panda-webinar-series - 2026-07-17

Popular science summary: Is RpS6 activation important for leukemia cell progression? Acute Myeloid Leukemia (AML) is the most common acute blood cancer in adults. It is characterized by a rapid increase of leukemic cells in the bone marrow, compromising the development of new blood cells. Despite improvement in treatments and advancements in supportive care, the overall 5-years survival of AML i

We prove that unary Sherali-Adams requires proofs of size nΩ(d) to rule out the existence of an nΘ(1)-clique in Erdős-Rényi random graphs whose maximum clique is of size d ≤ 2 log n. This lower bound is tight up to the multiplicative constant in the exponent. We obtain this result by introducing a technique inspired by pseudo-calibration which may be of independent interest. The technique involves

During mammalian ocular development, several signaling pathways control the spatiotemporal highly defined realization of the three-dimensional eye architecture. Given the complexity of these inductive signals, the developing eye is a sensitive organ for several diseases. In this study, we investigated a Dkk1+/- haploinsufficiency during eye development, resulting in coloboma and anterior eye defec

In recent years, scientists have advocated the use of targeted therapies in the form of drugs that modulate genes and proteins that are directly associated with cancer progression and metastasis. Malignant melanoma is a dreadful cancer type that has been associated with the rapid dissemination of primary tumors to multiple sites, including bone, brain, liver and lungs. The discovery that approxima

The aim of this paper was to examine how useable and inclusive the city is from the perspective of older bicyclists. Methods used were quantitative questionnaires and qualitative focus group interviews. Participants were people aged 65 years or older. The results showed that respondents were fairly satisfied with the transport infrastructure design. However, other road users seemed to complicate c

Neurodegenerative disorders are an increasingly common and irreversible burden on society, often affecting the aging population, but their etiology and disease mechanisms are poorly understood. Studying monogenic neurodegenerative diseases with known genetic cause provides an opportunity to understand cellular mechanisms also affected in more complex disorders. We recently reported that loss-of-fu

We prove that for k ≪ 4 n regular resolution requires length nΩ(k) to establish that an Erdős–Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent, and also implies unconditional nΩ(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.

Pancreatic endocrine cell differentiation depends on transcription factors that also contribute in adult insulin and glucagon gene expression. Islet cell development was examined in mice lacking MafB, a transcription factor expressed in immature alpha (glucagon(+)) and beta (insulin(+)) cells and capable of activating insulin and glucagon expression in vitro. We observed that MafB(-/-) embryos had

This paper presents analyses on the trends of IS curriculum development that has evolved since its inception from the classical report by the AIS/ACM task force led by Heikki Topi and colleagues published in 2010. Based on an integrated synthesis of the literature, we categorize it into three theoretically-driven dimensions: (i) IS Curricula; (ii) Topic-Based IS Curricula, and (iii) IS Identity Cr

We prove that for k ≫; 4√n regular resolution requires length nω(k) to establish that an ErdÅ's-Rényi graph with appropriately chosen edge density does not contain a k-clique. This lower bound is optimal up to the multiplicative constant in the exponent and also implies unconditional nω(k) lower bounds on running time for several state-of-the-art algorithms for finding maximum cliques in graphs.