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Suppose (f,X, μ) is a measure preserving dynamical system and φ: X → R a measurable function. Consider the maximum process Mn := max{X1, ,Xn}, where Xi = φ ○ fi-1 is a time series of observations on the system. Suppose that (un) is a non-decreasing sequence of real numbers, such that μ(X1 > un) → 0. For certain dynamical systems, we obtain a zero- one measure dichotomy for μ(Mn ≤ un i.o.) dependin
Sponge phase nanoparticles are lipid-based particles with a porous structure, forming pores with sizes up to 13 nm in diameter. These particles have been proposed for drug delivery by loading cargo within the pores, similar to how ionisable nanoparticles are used today. The larger pores could allow for larger cargo to be delivered to cells. Sponge phase nanoparticles, 277 ± 29 nm in diameter, were
The controlled delivery of micronutrients to soil and plants is essential to increase agricultural yields. However, this is today achieved using fossil fuel-derived plastic carriers, posing environmental risks and contributing to global carbon emissions. In this work, a novel and efficient way to prepare biodegradable zinc-impregnated cellulose acetate beads for use as controlled release fertilize
Protein therapeutics need to be formulated into an amorphous solid state to be stabilized, and this is efficiently done by spray drying together with a sugar matrix excipient. The characteristics of the produced powder are strongly dependent on process parameters, and therefore, spray drying offers the possibility of advanced particle engineering. In this thesis, trypsin was spray dried as a model
In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre-loading, where LL-37 was incorporated into a liquid
Due to rapid development of bacterial resistance against antibiotics, an emerging health crisis is underway, where ‘simple’ infections may no longer be treatable. Antimicrobial peptides (AMPs) constitute a class of substances attracting interest in this context. So far, research on AMPs has primarily focused on the identification of potent and selective peptides, as well as on the action mode of s
Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors
For the past fifteen years, ever since the Court of Justice’s ruling in its landmark case Bosman, the sporting rules governing player mobility have been a hot topic. The ruling prohibited transfer fees for players out-of-contract thus putting an end to the restrictive transfer system hindering the free movement of football players. The Court also abolished the nationality restriction where clubs w
Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by selective degeneration of the dopamine producing neurons in the substantia nigra. There is currently no clinically applicable therapy for treating or preventing Parkinsonian neurodegeneration. Great effort is put behind the development of novel therapeutic approaches that aim to alter the natural progression of the dise
Gene sequences form the primary basis for understanding the relationships among extant plant groups, but genetic data are unavailable from fossils to evaluate the affinities of extinct taxa. Here we show that geothermally resistant fossil cuticles of seed-bearing plants, analysed with Fourier transform infrared (FTIR) spectroscopy and hierarchical cluster analysis (HCA), retain biomolecular suites
Uppsatsen har undersökt huruvida spelföretaget Star Stable Entertainment AB marknadsföring av virtuella valutor och produkter till barn bryter mot EU:s konsumentskyddslagstiftning i ljuset av Sveriges Konsumenters anmälan mot företaget. Uppsatsen har även diskuterat om direktivet om otillbörliga affärs-metoder är anpassat för den digitala miljön med hänsyn till kommissionens aktuella fitness checkThe essay analyses whether the gaming company Star Stable Entertainment AB´s marketing of virtual currencies and other virtual products against chil-dren violates EU consumer law, considering the Swedish Consumers Associ-ation’s complaint against the company. The paper also discusses whether the Unfair Commercial Practice Directive (UCPD) is fit for the digital environ-ment, given the European Com
Följderna av narkotikamissbruk kostar samhället stora summor pengar varje år. Att beräkna den exakta storleken på dessa summor är omöjligt, eftersom stora delar av den narkotikarelaterade verksamheten är olaglig. De kostnadsberäkningar man kan göra blir ungefärliga uppskattningar. Ändå är det viktigt att försöka, eftersom den kunskap man har om kostnaderna för narkotikamissbrukets konsekvenser utg
Despite the consensus that reading is good for the individual, teachers seem to report the existence of a different mindset in the classroom as they struggle to motivate students to read. Research has indicated the existence of a growing gap between weak and strong readers, and that the fast-paced and technologically advanced society of today is noticeably affecting students’ reading habits. Howev
Sports facilities, in general, have the highest energy use in Sweden, compared with other buildings. Sports facilities are usually very wide and have a high ceiling height. This makes it hard for buildings as such to allow for the same daylight integration as in e.g. traditional office spaces. Electric lighting is very often used to supply the high illuminance demands inside sports halls. Since mo
