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Supramolecular hydrogels have attracted increasing attention in drug delivery, tissue engineering, and injectable biomaterials because of their high water content, good biocompatibility, and dynamic network structures. Cyclodextrin-based supramolecular systems can form network structures through host–guest interactions. These systems usually require mild cross-linking conditions and allow flexible

Suppose (f,X, μ) is a measure preserving dynamical system and φ: X → R a measurable function. Consider the maximum process Mn := max{X1, ,Xn}, where Xi = φ ○ fi-1 is a time series of observations on the system. Suppose that (un) is a non-decreasing sequence of real numbers, such that μ(X1 > un) → 0. For certain dynamical systems, we obtain a zero- one measure dichotomy for μ(Mn ≤ un i.o.) dependin

The controlled delivery of micronutrients to soil and plants is essential to increase agricultural yields. However, this is today achieved using fossil fuel-derived plastic carriers, posing environmental risks and contributing to global carbon emissions. In this work, a novel and efficient way to prepare biodegradable zinc-impregnated cellulose acetate beads for use as controlled release fertilize

In this study, the use of cubosomes for topical delivery of the antimicrobial peptide (AMP) LL-37 was investigated. Topical delivery of AMPs is of great interest for treatment of skin infections caused by bacteria, such as Staphylococcus aureus. AMP containing cubosomes were produced by three different preparation protocols and compared: (i) pre-loading, where LL-37 was incorporated into a liquid

Due to rapid development of bacterial resistance against antibiotics, an emerging health crisis is underway, where ‘simple’ infections may no longer be treatable. Antimicrobial peptides (AMPs) constitute a class of substances attracting interest in this context. So far, research on AMPs has primarily focused on the identification of potent and selective peptides, as well as on the action mode of s

Sponge phase nanoparticles are lipid-based particles with a porous structure, forming pores with sizes up to 13 nm in diameter. These particles have been proposed for drug delivery by loading cargo within the pores, similar to how ionisable nanoparticles are used today. The larger pores could allow for larger cargo to be delivered to cells. Sponge phase nanoparticles, 277 ± 29 nm in diameter, were

Protein therapeutics need to be formulated into an amorphous solid state to be stabilized, and this is efficiently done by spray drying together with a sugar matrix excipient. The characteristics of the produced powder are strongly dependent on process parameters, and therefore, spray drying offers the possibility of advanced particle engineering. In this thesis, trypsin was spray dried as a model

Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors

Parkinson's disease (PD) is a progressive neurodegenerative disorder caused by selective degeneration of the dopamine producing neurons in the substantia nigra. There is currently no clinically applicable therapy for treating or preventing Parkinsonian neurodegeneration. Great effort is put behind the development of novel therapeutic approaches that aim to alter the natural progression of the dise

Gene sequences form the primary basis for understanding the relationships among extant plant groups, but genetic data are unavailable from fossils to evaluate the affinities of extinct taxa. Here we show that geothermally resistant fossil cuticles of seed-bearing plants, analysed with Fourier transform infrared (FTIR) spectroscopy and hierarchical cluster analysis (HCA), retain biomolecular suites

Abstract The oomycete Phytophthora infestans, which causes the devastating late blight disease of potato, is notorious for developing resistance to conventional control strategies (fungicide application and resistance breeding by introgression of R gene). To increase our tool box of disease management strategies available to combat P. infestans, there is a need to explore several new approaches th

https://www.real.lu.se/yulia-vakulenko - 2026-07-22

In my thesis I have chosen to immerse myself in the regional power line network and how it will be built. I have chosen this topic because it is a significant question today and in the future. The investments and technical choices made today, will affect the outcome on the society of tomorrow. When the local power line network was rebuilt, after the hurricane Gudrun in the year 2005, it implied a