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Background and purpose: During radiotherapy, rectal cancer patients show inter-fractional internal motion that effects the delivered dose distribution. The purpose of this work is to study I) the inter-fractional bladder volume change, II) the effect of bladder volume change on bowel dose distribution, III) the effect of bladder optimization on the relationship between bladder volume and bowel dos

Background: The apolipoprotein E (APOE) ε4 allele is associated with higher cholesterol levels, and an increased risk of developing Alzheimer’s disease (AD) and amyloid-related imaging abnormalities after initiation of amyloid-modifying therapies. A worse cognitive response to cholinesterase inhibitor (ChEI) treatment and longitudinal outcome in APOE ε4-carriers has been observed. Based on these c

Background: Mental health problems are prevalent among adolescents with severe obesity, but long-term mental health outcomes after adolescent bariatric surgery are not well known. We aimed to assess mental health outcomes over 5 years of follow-up after Roux-en-Y gastric bypass surgery in adolescents who participated in the Adolescent Morbid Obesity Surgery (AMOS) study. Methods: This was a non-ra

Hjärtsvikt betecknar ett syndrom som innebär att hjärtat har otillräcklig förmåga att försörja kroppen med blod. Detta kan antingen bero på att hjärtat inte kan fyllas med eller stöta ut tillräckligt med mängd blod. Patienter med hjärtsvikt har i allmänhet hög dödlighet, detta trots att stora framsteg har gjorts avseende behandlingen av hjärtsvikt, speciellt sedan 1980-talet. Femårsöverlevnaden föIntroduction: Despite major advances, the incidence rate and mortality of heart failure (HF) remains high, with a five-year survival of approximately 50%. At the time of inception of this thesis the familial risks of HF, including the aspects of mortality, were largely underdetermined. This thesis is composed of four papers with the main aims as follows:To determine the risk of hospitalization of

IMPORTANCE: Prostate-specific antigen (PSA) screening has potential to reduce prostate cancer mortality but frequently detects prostate cancer that is not clinically important.OBJECTIVE: To describe rates of low-grade (grade group 1) and high-grade (grade groups 2-5) prostate cancer identified among men invited to participate in a prostate cancer screening protocol consisting of a PSA test, a 4-ka

The aim of the project MASTER (MAnaging Speeds of Traffic on European Roads) was to produce information that can be cited in the preparation of national and EU decisions concerning speed management and speed control equipment standards. For this purpose, the project looked for answers to three key questions: 1)What are acceptable ranges of speeds? 2)What are the key factors influencing drivers’ ch

Popular Abstract in Swedish Avhandlingen handlar om hur fett (lipider) i kosten bryts ner och transporteras i blodet för att slutligen antingen användas som energi, byggstenar i cellväggarna eller lagras i fettväven. I den här avhandlingen kan man också läsa om hur man kan modifiera fetter med hjälp av speciella proteiner: enzymer för att förbättra näringsinnehållet och dess fysikaliska egenskaperAn important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. High concentrations and long circulation times of TRL remnants may be detrimental since these are considered to be highly

BACKGROUND: HYPO-RT-PC is a phase 3 trial comparing ultra-hypofractionated and conventionally fractionated radiotherapy in intermediate-to-high-risk localised prostate cancer. This 10-year update reports long-term efficacy and toxicity outcomes.METHODS: In this open-label, randomised, phase 3, non-inferiority trial done in ten centres in Sweden and two in Denmark, we recruited men aged 75 years or

Background: Current evidence supports the use of intravenous thrombolysis with alteplase in patients with wake-up stroke selected with MRI or perfusion imaging and is recommended in clinical guidelines. However, access to advanced imaging techniques is often scarce. We aimed to determine whether thrombolytic treatment with intravenous tenecteplase given within 4·5 h of awakening improves functiona

Background: Exposure and Response Prevention (ERP) is a form of behavioural therapy for tics; however, its effectiveness remains uncertain. We aimed to evaluate the effectiveness of internet-delivered, therapist-supported, and parent-assisted ERP for treatment of tics in children and young people with Tourette syndrome or chronic tic disorder. Methods: This multicentre, parallel group, single-blin

Background Breast cancer is the most frequently diagnosed cancer in women. Survival is generally considered favourable, yet some patients remain at risk of early death. We aimed to assess whether comprehensive whole-genome sequencing (WGS) linked to mortality data could add prognostic value to existing clinical measures and identify patients who might respond to targeted therapeutics. Methods In t

Background: Current systemic therapies for metastatic pancreatic ductal adenocarcinoma are associated with poor outcomes with a 5-year overall survival rate under 5%. We aimed to assess the safety and antitumour activity of mitazalimab, a human CD40 agonistic IgG1 antibody, with modified FOLFIRINOX (mFOLFIRINOX; fluorouracil, leucovorin, oxaliplatin, and irinotecan), in chemotherapy-naive patients

Objective: To report outcomes of urgent juxtarenal/pararenal aneurysms (J/P-AAAs) managed by off-the-shelf multibranched thoracoabdominal endografts (Cook, T-branch). Methods: In this observational, multicenter, retrospective study, patients with J/P-AAAs treated by urgent endovascular repair by T-branch in 23 European aortic centers, from 2013 to 2023, were analyzed. Contained J/P-AAAs rupture, p

This study aims to investigate and disentangle the impact of land use and climate variability on the Baltic Sea coastal zone from a millennial perspective. To assess the environmental status of the coastal zone we make use of siliceous microfossils (mainly diatoms), stable nitrogen and carbon isotopes, organic carbon accumulation rates, and lithological changes analyzed in a sediment core collecte

Centre for Economic Demography Lund University School of Economics and Management P.O. Box 7083 SE-220 07 Lund, Sweden www.ed.lu/publications/Lund-Papers-in-Economic-Demography/ Heterogeneous Effects of Birth Spacing on Neonatal Mortality Risks in Bangladesh JOSEPH MOLITORIS LUND PAPERS IN ECONOMIC DEMOGRAPHY 2017:4 Copyright is held by the author(s). Lund Papers in Economic Demography are circula

https://www.lusem.lu.se/sites/lusem.lu.se/files/2024-07/LPED_2017_4_0.pdf - 2026-07-04

Brevmall 3 Report on a case of suspected cheating in connection with [an exam, a submitted assignment or the academic task in question] [Name], [personal identity number], [address, email], is hereby reported for suspected cheating by [e.g. plagiarism/unauthorised collaboration/use of unauthorised aids] in connection with [an exam, a submitted assignment or the academic task in question] comprisin

https://www.staff.lu.se/sites/staff.lu.se/files/2021-03/mall_anm_fusk_eng210218_0.doc - 2026-07-04

Guidelines for communication work at Lund University Page 1 of 5 Vice-Chancellor Reg. No. § STYR 2014/95 18 December 2014 Guidelines for communication work at Lund University 1. Introduction and aim These guidelines are mainly based on the 2012–2016 Strategic Plan (reg. no LS 2011/162), which addresses the importance of visibility and clarity with regard to Lund University’s external and internal

https://www.staff.lu.se/sites/staff.lu.se/files/2023-10/guidelines-for-communication-work-at-lund-university.pdf - 2026-07-04

The association between stressful life events and respiratory infections during the first 4 years of life: The Environmental Determinants of Diabetes in the Young study Received: 4 April 2018 Revised: 6 February 2019 Accepted: 7 February 2019 DOI: 10.1002/smi.2861 R E S E A R CH AR T I C L E The association between stressful life events and respiratory infections during the first 4 years of life:

https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-12/104%2005072019_679_104_MP30_Roth_Stress%20Health_2019.pdf - 2026-07-04

Dnr STYR 2021/2184 Framtidens ledarskapsutveckling vid Lunds universitet Slutrapport av Maria Flores Andreas Bryngelson 2 Sammanfattning Nyligen genomförda utredningar och utvärderingar visar att ledarskapet vid Lunds universitet är ett utvecklingsområde som kan bidra till framstående forskning, utbildning och samverkan samt medarbetares hälsa och välbefinnande. Vid Lunds universitet genomfördes d

https://www.hr-webben.lu.se/sites/hr-webben.lu.se/files/2026-01/Rapport%20Framtidens%20ledarutveckling%20Lunds%20universitet%202022%2010%2031.pdf.pdf - 2026-07-04