Filtyp
Purpose: To estimate the impact upon Health-Related Quality of Life (HRQOL) associated with Type 1 Diabetes Mellitus (T1DM), both with and without associated diabetic complications, for enabling calculation of utility values – Quality of Life Weights (QLW) – for populations with T1DM. Method: Two cohorts from Northern Sweden, one of T1DM patients and one of a general population, were given survey
Background: Perlecan is a heparan sulfate proteoglycan (HSPG) constituent of the extracellular matrix with roles in cell growth, differentiation, and angiogenesis. The role of the HS side chains in regulating invivo angiogenesis after hind-limb ischemia is unknown. Methods: Heparan sulfate (HS)-deficient perlecan (Hspg2 δ3/δ3
Background: Endocrine disrupting chemicals (EDCs) are xenobiotics with the ability to interfere with hormone action, even at low levels. Prior environmental epidemiology studies link numerous suspected EDCs, including phthalates and bisphenol A (BPA), to adverse neurodevelopmental outcomes. However, results for some chemicals were inconsistent and most assessed one chemical at a time. Objectives:
BACKGROUND: Cardiovascular magnetic resonance (CMR) can be used to measure left ventricular end-diastolic volume (LVEDV) and left ventricular mass (LVM). However, there is currently no good way to measure the normality of LVM in relation to a given LVEDV. We hypothesized that a simple measure of left ventricular global wall thickness (GWT) would be accurate, beneficial for detecting and characteri
Background: 27-Hydroxycholesterol (27HC) stimulates estrogen receptor-positive (ER+) breast cancer (BC) progression. Inhibiting the sterol 27-hydroxylase (CYP27A1) abrogates these growth-promoting effects of 27HC in mice. However, the significance of CYP27A1 expression on BC biology and prognosis is unclear. Methods: Intratumoral CYP27A1 expression in invasive BC was measured by immunohistochemist
Objective: The number of type-II endometrial cancer patients has been increasing and the prognosis is not favorable. We aim to investigate whether sarcopenia index in any of several different muscles could serve as a novel biomarker of prognosis in patients with type-II endometrial cancer. Methods: We retrospectively investigated a total of 194 patients at four hospitals. Ninety patients were trea
- en spegling av vårt kalendarium Här visas evenemang som arrangeras av Pufendorfinstitutet och våra grupper. De flesta evenemang är öppna för andra forskare på Lund universitet och intresserad allmänhet, men kan kräva registrering. Se information om vem evenemanget vänder sig till och hur man deltar under respektive evenemang. Sidans innehåll är en spegling av vårt kalendarium. Inställningen gör
https://www.pi.lu.se/vad-hander-pa-pufendorfinstitutet/pufendorfinstitutets-evenemang - 2026-07-09
https://www.real.lu.se/diogo-figueirinhas - 2026-07-10
Regular prophylactic treatment with factor VIII (FVIII) and factor IX (FIX) concentrates in hemophilia A and B, respectively, is introduced in early infancy and has resulted in dramatic improvement of the conditions. Recombinant FVIII and FIX concentrates have been available for > 25 years and have been modified and refined through the years; however, unfortunately frequent intravenous administrat
The debate on the legislation on sexual offense has a long history regarding the current wording, which defines the circumstances of the crimes rape and sexual coercion should be removed and the line between criminal and unpunished deed should be drawn at the level of whether participation was involuntarily. In October 2016 the Sexual Offences Committee introduces a new SOU (Swedish Government Off
Basic human rights are not being met in many parts of the world. People in poverty suffer from hunger, ill-health, poor education and low standards of living which negatively affect their well-being. These reasons and poverty as a wide spread social problem that undermines the economy and development of entire nations, make poverty socially relevant and important to study. To understand how poor p
