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Robert Alexy’s theory of legal argumentation is among the notable contributions made to mainstream jurisprudence in the last three decades. Remaining true to its rational discursive mission, it engages with both analytical positivism and natural law theories. A recent collection of essays edited by George Pavlakos explores Alexy’s theory from a number of philosophical standpoints, revealing its th
It is of paramount importance that software reliability requirements not only can be formulated, but also enforced and evaluated before accepting a software product for release. This requires sound acceptance criteria for software, which implies that methods for evaluating the software reliability are needed during the testing phase. Thus, theoretical models which are practically applicable are ne
Given a directed graph as input, we show how to efficiently find a shortest (directed, simple) cycle on an even number of vertices. As far as we know, no polynomial-time algorithm was previously known for this problem. In fact, finding any even cycle in a directed graph in polynomial time was open for more than two decades until Robertson, Seymour, and Thomas (Ann. of Math. (2) 1999) and, independ
The levels and conformers of alpha-synuclein are critical in the pathogenesis of Parkinson's Disease and related synucleinopathies. Homeostatic mechanisms in protein degradation and secretion have been identified as regulators of alpha-synuclein at different stages of its intracellular trafficking and transcellular propagation. Here we review pathways involved in the removal of various forms of al
Axonal degeneration, which contributes to functional impairment in several disorders of the nervous system, is an important target for neuroprotection. Several individual factors and subcellular events have been implicated in axonal degeneration, but researchers have so far been unable to identify an integrative signaling pathway activating this self-destructive process. Through pharmacological an
Abstract in UndeterminedContrary to the notion that altering our ordinary state of consciousness necessarily produces delusional beliefs and is generally deleterious, various findings in psychology and other disciplines suggest that 1) the ordinary state of consciousness does not provide an accurate mapping of reality and 2) alterations of consciousness can have various positive functions. Among t
An insight into the proteome status of today is presented, covering aspects of market values, new scientific literature sources, new technology initiatives and future developments. The authors give a personal view of the importance and the expected progress of microtechnology in proteome research. The background to some of the fundamental analytical technologies where for example, chromatography h
The most unfavourable orientation of a straight crack of given length is investigated, assuming mode I growth. It is shown that this orientation is not always the one perpendicular to the largest principal stress. If the smallest in-plane principal stress is compressive and its magnitude more than about one third of the largest (tensile) in-plane stress, then some other orientations are more unfav
Purpose: The purpose of this study was to investigate how theories regarding core values and cultural shifts could contribute to the segmentation research field. The aim of this study was further to investigate how to attract an additional segment without loosing the original target audience. To exemplify we did a case study regarding whether it is possible for, an existing brand operating in the
“Buy one – get one free!” is one of hundreds of commercial messages you see every day. Recent research has concluded what salespeople have known for decades; there is something peculiar about offers involving the concept of free. Suddenly people start to behave irrationally and make choices far from the predictable safe havens of classical economic theory. This thesis test the existence of a zero-
China’s economic development since the beginning of the reform in 1978 has been impressive. Regardless of China’s poor financial banking system and lack of legal enforcements, the growth of Chinese firms makes China’s GDP one of the fastest growing in the world. This paper endeavors to answer the question of formal financial system or its counterpart the alternative informal finance are associated
The purpose of this thesis is to explore how differences in morality polarizes the debate of what the function of the university should be, and how that might indicate a potential organizational crisis for Lund University. The study is primarily based on the case concerning the removal of teacher Johan Grant, that took place at Lund University in the fall of 2019. The thesis intends to expand know
Purpose: With the increasing importance of unbiased conversational agents, this research investigates how debiasing strategies can be used to prevent cognitive biases from impacting conversation agents in the development process. A research gap was identified in the literature of prevention strategies for the management of cognitive biases. Therefore, existing literature on debiasing is explored a
Herpes simplex virus type 1 (HSV-1) packages its micrometers-long double-stranded DNA genome into a nanometer-scale protein shell, termed the capsid. Upon confinement within the capsid, neighboring DNA strands experience repulsive electrostatic and hydration forces as well as bending stress associated with the tight curvature required of packaged DNA. By osmotically suppressing DNA release from HS
