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The primary aim of this study is to assess the significance of top management commitment in the context of Lean 4.0 implementation within the pharmaceutical manufacturing industry in Ghana. The study seeks to understand and evaluate the overall effectiveness and achievements associated with adopting Lean 4.0. Employing a positivist mindset, the research utilizes an explanatory quantitative researc
Aim: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. Methods: All patients operated for rectal cancer, tumour height
We developed an analytical method and constrained procedural boundary conditions that enable accurate and precise Zn isotope ratio measurements in urban aerosols. We also demonstrate the potential of this new isotope system for air pollutant source tracing. The procedural blank is around 5 ng and significantly lower than published methods due to a tailored ion chromatographic separation. Accurate
To analyse longitudinal changes in passive range of motion (ROM) in the upper limb in adults with cerebral palsy (CP). Method: Passive ROM for shoulder abduction and flexion, supination, and elbow and wrist extension was analysed in a longitudinal cohort of adults aged 16 to 76 years from the Swedish CP registry. Individual ROM trajectories and mean ROM curves were calculated using the Manual Abil
The timing of the spring season in the boreal region is shifting under global warming, with profound impacts on ecosystems and hydrological processes. However, the mechanisms driving this transition and its considerable interannual variability are not well described, especially regarding the influence of large-scale atmospheric teleconnection patterns. This study examines the temporal variability
Uronate isomerase (EC 5.3.1.12; URI) catalyzes uronate sugar interconversion, a key step in bacterial metabolism, yet its reaction mechanism remains poorly understood. This study delineates the detailed mechanism for the isomerization of d-glucuronate to d-fructuronate catalyzed by a Zn2+-dependent URI enzyme (from Bacillus halodurans). Using quantum mechanical (QM) cluster calculations, three mec
Background: Approximately 15% of Canadian adults live with two or more chronic diseases, many of which are obesity related. The degree to which Canadian obesity treatment guidelines are integrated into chronic disease management is unknown. Methods: We conducted a 12-min online survey among a non-probability sample of 2506 adult Canadians who met at least one of the following criteria: 1) BMI ≥30
Nature contains an endless supply of natural products and has for long been a source of inspiration for the pharmaceutical industry. Many of the drugs currently in clinical use originate from natural products. Paclitaxel, the active substance in the anti cancer medicine Taxol, was first isolated from the Pacific yew tree (Taxus brevifolia) in the early 1960s during a screening program for novel an
Objective: The aim of this study was to investigate whether self-administered Emotional Freedom Techniques (EFT) lead to reduced pain perception, increased acceptance and coping ability, and better health-related quality of life in individuals with fibromyalgia. Methods: Eighty-six women, diagnosed with fibromyalgia and on sick leave for at least 3 months, were randomly assigned to a treatment gro
BACKGROUND: The spinal cord is composed of a large number of cells that interact to allow the organism to function. To perform detail studies of cellular processes involved in spinal cord injury (SCI), one must use repeatable and specific methods to target and injure restricted areas of the spinal cord.NEW METHOD: We propose a robust method to induce SCI in zebrafish by laser light. With a 2-photo
Objective: The aim of this study was to assess information literacy performance of students doing their master thesis at 5th year the Medical Degree Programme, Lund University, Sweden. The study investigates if there is a difference in performance between library class participants and non-participants. Method: A case-control approach with rubrics assessment was used to assess students’ informati
Objectives: This study aimed to assess how transfers of clinical prediction models for early trauma care between different care contexts within a single health system affected mistriage rates. Study Design and Setting: Patients aged 15 years or older, registered between 2011 and 2016 in the Swedish national trauma registry, SweTrau, were included. Three data set groups were created: high- and low-
Denna avhandling omfattar en komparativ studie av systemen för domstolsprövning av förvaltningsbeslut enligt svensk, dansk och österrikisk rätt. Framställningen omfattar en rättslig analys av de regler och principer som styr dels när en domstolsprövning av förvaltningsbeslut kan komma till stånd (vilka sakprövningsförutsättningar som gäller), dels vad en sådan prövning omfattar och kan leda till (This thesis contains a comparative study of the systems of judicial review of administrative decisions in Swedish, Danish, and Austrian law. The main aim of the study is to explore how the three legal systems balance certain interests and functions that are related to the phenomenon of judicial review of administrative acts: on the one hand, the principle of effective judicial protection as well a
Objective: To examine the prevalence of dysnatraemias among children admitted for paediatric surgery before and after a change from hypotonic to isotonic intravenous maintenance fluid therapy. Design: Retrospective consecutive time series intervention study. Setting: Paediatric surgery ward at the Children's Hospital in Lund, during a 7-year period, 2010-2017. Patients: All children with a blood s
Background: Abdominal aortic aneurysm (AAA) and cardiovascular disease are intimately associated, the latter representing the most common cause of death in Sweden. Cardiac complications are held responsible for the majority of perioperative morbidity and mortality in patients undergoing repair of AAA. The importance of preoperative thorough cardiac assessment is therefore obvious. The aim of this
Background:Central haemodynamics have in recent years emerged as a promising predictor of cardiovascular health and risk of cardiovascular disease (CVD). Central haemodynamics are affected early in the development of vascular aging and contributes to target organ damage. Carotid-femoral pulse wave velocity (c-f PWV), augmentation index (Aix) and central SBP (cSBP) are variables that reflect arteri
3D-macroporous chitosan-based scaffolds (cryogels) were produced via growth of metal-polymer coordinated complexes and electrostatic interactions between oppositely charged groups of chitosan and metal ions under subzero temperatures. A mechanism of reduction of noble metal complexes inside the cryogel walls by glutaraldehyde is proposed, which produces discrete and dispersed noble metal nanoparti
