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BACKGROUND: Recent research using a data-driven cluster approach has identified five discordant subclassifying body mass index (BMI) subgroups, characterized by cardiometabolic biomarkers deviated from those predicted by BMI.OBJECTIVE: This study aimed to investigate the associations of these subgroups with risks of metabolic dysfunction-associated steatotic liver disease (MASLD) and liver-related
Second language acquisition (SLA) research has historically prioritized classroom-based contexts, with the exception of areas such as study abroad, incidental and self-directed learning. In the last decades, however, research interest in second language (L2) learning beyond the classroom has grown substantially, expanding our understanding of where and how L2 learning takes place. This can be larg
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pathogenesis is shaped not only by viral entry mechanisms but also by interactions with host and microbial factors. The viral spike (S) protein can bind Gram-negative bacterial lipopolysaccharide (LPS), a driver of hyperinflammation in severe COVID-19. How viral evolution over the years alters this interaction remains unclear. Here, we i
The majority of microarray studies focus on analysis of gene expression differences between various specimens or conditions. However, the causes of this variability from one cancer to another, from one sample to another and from one gene to another often remain unknown. In this study, we present a systematic procedure for finding genes whose expression levels are altered due to an intrinsic or ext
Type 1 diabetes mellitus (T1DM) is an autoimmune disease in which the 0 cells in the pancreas are destroyed by the body's own immune system. IL12 plays a role in pathological situations, such as septic shock, tissue damage during inflammation, and organ-specific autoimmune diseases. In NOD mice, administration of IL12 induces T1DM and administration of IL12 antagonists prevents T1DM. Linkage and a
Encountering waves overtaking a ship sailing on the ocean may cause instability. Therefore it is of great importance to study the properties of such waves, for example slope, wavelength and amplitude. When making statistics on the properties of overtaking waves, only the waves that are faster than the ship will affect the resulting distribution. Thus the velocity of the individual waves plays an i
The photochemistry of low lying excited states of six different fluorinated bromobenzenes has been investigated by means of femtosecond laser spectroscopy and high level ab initio CASSCF/CASPT2 quantum chemical calculations. The objective of the work was to investigate how and to what extent light substituents, position on the benzene ring and number, would influence the dissociation mechanism of
Starting out from the rather different views on Ego and Alter formulated by Peirce and Bakhtin, and, more indirectly, by Foucault, the present contribution attempts to characterise the position of these familiar philosophical personages within the framework of cultural semiotics, as it has been adapted in Lund from the models of the Prague and Tartu schools. The resulting model is tried out in a c
Popular Abstract in Swedish I denna avhandling behandlas brosk proteiners roll såsom antigen och tillgänglighet av immunsystemet i artrit. Sex artiklar omfattas, där fyra presenterar nya djur modeller för reumatoid artrit (RA), en visar hur en genetisk störning av ett broskprotein kan förvärra artrit och den sista hur posttransnationell modifiering av kollagen typ II (CII) påverkar T-cells toleranIn this thesis the role of cartilage proteins and their potential as antigen and availability to the immune system in arthritis were investigated. Six papers are included; where four present new animal models for Rheumatoid arthritis (RA), one shows how genetic disorders in cartilage may affect arthritis and the last how posttranslational modification of collagen type II (CII) affects tolerance. P
The Baltic Sea Region is rapidly becoming one of the world’s more competitive regions. The region is capitalising on its strengths and making the most of its diversity to stimulate innovation, build a strong pool of skilled labour and foster entrepreneurship. A deep spirit of co-operation and integration has led the Baltic Sea countries to set up ambitious governance frameworks to pursue economic
New institutional theory has been critizised, for describing institutionalization as a static qualitative state rather than a process. In this paper we provide an extended understanding of the process of institutionalization by replacing the mechanical concept of diffusion by the concept of translation and an analytical model of "trevel of ideas". Analyzing the field material from three cases of t
During recent years, mobile phone companies have experienced market-related difficulties that result in increasing competition globally. In an attempt to maintain or increase their market share, enterprises reorganize their resources and employ new technologies to sharpen their competitive edges. Moreover, with the globalization, more and more companies become multi-sited. Efficient and timely col
This paper presents an investigation method for studying cascading effects in incidents, which is to some extent lacking in the scientific literature. Several incident investigation methods are reviewed and used to influence the presented method. The usefulness of the method is demonstrated in a case study for a recent event in Sweden, a severe flooding event in the city of Malmö in south of Swede
We explain autonomy with full-fledged reference to the complementaristic conception of language and its introspective capabilities. This field that we refer to is understood to belong to a wider epistemic category than that of (the received view of) semiotics as well as of systems science. It follows from the linguistic complementarity that autonomies (self-references; independencies) can never be
Because of the stratospheric ozone depletion that took place during the last decades of the past century, the effects of ultraviolet radiation on plants, animals, humans and micro-organisms became intensively studied. In this chapter we describe the role of the ozone layer as a radiation shield and various molecular and organismal effects of ultraviolet radiation, with an emphasis on the UV-B band
The chapter introduces the overriding question of the volume—whether poor countries can catch up—by providing an overview of theories and approaches that have contributed to this discussion. It argues for the importance of introducing to the analysis the role of structural transformation and to acknowledge that the conditions for economic development vary from case to case. Instead of clinging on
Popular Abstract in Swedish Avhandlingen följer den konfliktladdade relationen mellan far och son i Sven Delblancs författarskap och visar hur en lysande berättarkonst växer fram i samspelet mellan minne och fiktion.In 1991, a year before his death, Sven Delblanc published his highly acclaimed autobiography, Livets ax. At the centre of these childhood memories lies the author’s problematic relationship to his father. In view of the attention attracted by Livets ax, it is not surprising that biographical interpretations of Delblanc’s oeuvre have been predominant. It is evident that the writer’s difficult child
Fe 0 fluorescence by PAR has been investigated in eight symbiotic starshaving a wide range in temperature of the hot component and orbitalperiod. The data used are spectra obtained from the IUE archive. Allpumping lines investigated in this work are in the short wavelengthregion of IUE (1200-2000 Å), except for He 0 λ 1084.942 andO 0 λ 1032.041. The resulting Fe 0 fluorescence lines are mainlyin t
