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Assessment of programmed cell death ligand 1 (PD-L1) immunohistochemical staining is used for decision on treatment with programmed cell death 1 and PD-L1 checkpoint inhibitors in lung adenocarcinomas and squamous cell carcinomas. This study aimed to compare the staining properties of tumor cells between the antibody clones 28-8, 22C3, SP142, and SP263 and investigate interrater variation between
Due to the significant increase in pediatric trunk computed tomography (CT) examinations, there is a need for a reliable approach of conducting effectivedose estimate for such procedures. The current study is based on two dosimetric anthropomorphic phantoms representing a 1-year and a 5-year old child. Effectiveand equivalent tissue doses from CT examinations of the trunk were determined by thermo
Background: Primary hyperparathyroidism (PHPT) is associated with cardiac disease and increased risk of all-cause and cardiovascular mortality. We investigated cardiac structural and functional parameters before and after successful parathyroidectomy in asymptomatic PHPT patients. Methods and Results: Forty-nine PHPT patients (age: 62.9 +/- 11 years, 5 men) and 48 healthy control subjects, matched
Water–biomolecule interactions have been extensively studied in dilute solutions, crystals, and rehydrated powders, but none of these model systems may capture the behavior of water in the highly organized intracellular milieu. Because of the experimental difficulty of selectively probing the structure and dynamics of water in intact cells, radically different views about the properties of cell wa
Background Knowledge about how elderly persons perceive the impact of chronic heart failure (CHF) on daily life is important when planning nursing care. For this purpose, disease specific instruments are needed. However, few instruments have been developed or tested specifically on elderly persons. Aim To validate a Swedish version of the Minnesota Living with Heart Failure Questionnaire (LHFQ)
Ligands usually bind to proteins by displacing water from the binding site. The affinity and kinetics of binding therefore depend on the hydration characteristics of the site. Here, we show that the extreme case of a completely dehydrated free binding site is realized for the large nonpolar binding cavity in bovine beta-lactoglobulin. Because spatially delocalized water molecules may escape detect
Föreliggande studie har undersökt implementering av terapeuters erhållna kunskaper efter att ha genomgått vidareutbildning i biologisk traumabehandling, som är en utbildning för behandling av trauma med utgångspunkt i kroppen. Två frågeställningar har studerats: 1) Vilket kunskapsinnehåll och vilka kunskapsformer står i fokus när terapeuterna reflekterar över sin praktik i biologisk traumabehandliThe purpose of this study is to examine the implementation of knowledge acquired by therapists after having taking part in a further education course of biological trauma treatment, which aimed at using the body as a starting point for trauma treatment. Two issues have been studied: 1)What content of knowledge and what forms of knowledge have the therapists reflected about in their practice of bio
Issue: Does a statistical relationship between OMXS30 and S&P500 plus OMXS30 and DAX30 exist after extreme returns? Is it possible to explain the relationship between OMXS30 and S&P500 plus S&P500 and DAX30 with the chosen economic theories? Purpose: The purpose is to examine the effects on OMXS30 during 6 days after extreme returns on S&P500 or DAX30 are present. These effects wi
Neutralitetskonceptet växte fram under en tid då konflikter mellan länder fortfarande var en regional angelägenhet. Idag har kollektiva säkerhetssystemet i FN-stadgan konverterat dessa konflikter till en global angelägenhet. Syftet med uppsatsen är att undersöka korrelationen mellan neutralitetslagstiftningen och FN-stadgan och hur detta påverkar neutrala stater inom FN. Frågeställningen är i viThe concept of neutrality emerged at a time when conflicts between states were still regional matters. Today the system of collective security within the UN Charter has converted these conflicts into a global issue. The purpose of this essay is to examine the correlation between the law of neutrality and the Charter of the United Nations and how this affects the neutral member states of the Unit
Kings of the Wyld av Nicholas Eames är en fantasyroman som blandar mörka teman med humor och som väver in allusioner till såväl nördkultur såväl som 70-talsrock. I den här magisteruppsatsen diskuterar jag översättning av namn, allusioner och alluderande namn i fantasy, med utgångspunkt i min översättning av två utdrag ur romanen. Uppsatsen inleds med en källtextanalys av hela romanen, med specifik
While the environmental justice movement has grown worldwide, it seems that the movement has yet to mobilise in South Africa. The instances of environmental injustices in South Africa are abundant but paradoxically this has not given rise to a united movement demanding environmental justice for a transition to a new and renewable energy path. This thesis explores the challenges of creating an envi
In this essay, I will examine what Origen of Alexandria believed about the resurrection of the body. Origen was condemned as a heretic at the Second Council of Constantinople in 553, one of the main reasons for this was that he was said to deny the physical resurrection of the body. Due to the condemnation of Origen, the work of copying his works was also stopped, with the result that many of Orig
Background: There has been substantial progress in epidemiological research on prostate cancer over the last decade. An area of increasing interest is the possible role of sexual activity and history of sexually transmitted infections as a risk factor for prostate cancer. Specific sexually transmitted infections have only inconsistently been associated with prostate cancer, with positive associati
In contemporary nuclear physics, the European Advanced GAmma Tracking Array (AGATA) represents a crucial detection system for cutting-edge nuclear structure studies. AGATA consists of highly segmented high-purity germanium crystals and uses the pulse-shape analysis technique to determine both the position and the energy of the γ-ray interaction points in the crystals. It is the tracking algorithms
Detta arbete behandlar frågan om vad det inom migrationsrätten gällande beviskravet sannolikt innebär ur ett sannolikhetsteoretiskt perspektiv vid tillämpning framför allt av utlänningslagen (2005:716) 4 kap. 1 §. Utvald del av denna paragraf tolkas och delas upp i delteman. Utifrån dessa delteman undersöks vad som måste uppnå vilken sannolikhet och hur sannolikheten för olika delteman påverkar saThis is a thesis on the issue of what the evidentiary requirement within the field of migration law, probable, implies, from a probabilistic point of view, especially when applying the 1st article of the 4th chapter in the Swedish Aliens Act (2005:716), about refugee status. A selected part of this article is interpreted and divided into sub-themes of proof (these could also be referred to as prop
This thesis explores the legal position of permanent residents as compared to that of citizens in the case study of Georgia. With this aim, the thesis first examines the general legal system of the case study and delves into its sphere-specific regulations, which restrict access to different areas of life to permanent residents. The thesis then applies the standards extrapolated from the internati
