Filtyp
Background Group 5 allergens are small proteins that consist of two domains. They belong to the most potent respiratory allergens. Objective To determine the binding sites and to study allergic patients' IgE recognition of the group 5 allergen (Phl p 5) from timothy grass pollen using human monoclonal IgE antibodies that have been isolated from grass pollen allergic patients. Methods Using recom
In nine hyperthyroid women studied in the follicular phase of the menstrual cycle basal plasma LH concentrations and LH and FSH responses to GnRH were increased compared to those in nine normal women. The increased gonadotropin levels could not be related to changes in body weight or plasma estradiol or serum sex hormone-binding globulin levels, and they approached normal levels during or after tr
Cancer cells evade the immune system by downregulating antigen presentation. Although immune checkpoint inhibitors (ICI) and adoptive T-cell therapies revolutionized cancer treatment, their efficacy relies on the intrinsic immunogenicity of tumor cells and antigen presentation by dendritic cells. Here, we describe a protocol to directly reprogram murine and human cancer cells into tumor-antigen-pr
Swedish institutions of higher education must promote widening participation. This goal is also expressed in policy documents at Lund University. To accomplish this, teachers at Lund University formed a group to strategically work towards student inclusion. This article reports on an interview study conducted by this group investigating students’ experiences and perceptions of entering education a
Chromosome abnormalities, in particular translocations, and gene fusions are hallmarks of neoplasia. Although both have been recognized as important drivers of cancer for decades, our knowledge of the characterizing features of the cytobands involved in recombinations is poorly understood. The present study, based on a comparative analysis of 10 442 translocation breakpoints and 30 762 gene fusion
Myxoid liposarcoma (MLS) is molecularly characterized by fusions involving the DDIT3 gene in chromosome band 12q13; the fusion partner is FUS in band 16p11 in 90–95% of the cases and EWSR1 in band 22q12 in the remaining 5–10%. Hence, molecular studies, often fluorescence in situ hybridization (FISH) for DDIT3 rearrangement, are useful for establishing a correct diagnosis. Although all MLS tumors s
This chapter examines the relationship between the United Nations (UN) and African troop contributing countries (TCCs). As a continent which has both hosted and contributed to numerous UN peacekeeping missions, Africa has shaped and is shaped by peacekeeping practices. This chapter considers African states' historical presence in UN peacekeeping operations since the 1960s and distinguishes between
Building on the case of three municipal currencies (in Brazil, Spain and Belgium), the policy brief argues municipal currencies can be considered transversal careinfrastructures because, depending on their design and governance, theyfacilitate the visualization and circulation of economic, social andenvironmental value in ways that directly address community needs, enhancesocial welfare, promote e
Recent research has highlighted the importance of reducing economic shrinking—periods of negative per capita growth—for long-term development. Building on this literature, this chapter proposes a new framework explicitly connecting the dynamics of poverty eradication to the dynamics of resilience to economic shrinking. It argues that a key driver of this resilience is the alignment of incentives b
This chapter critically engages with a central policy norm developed by key international actors working on statelessness and refugeeness over the last three decades. This is the norm that for stateless refugees their refugeeness effectively trumps their statelessness. I term this norm, which arbitrarily separates and ranks statelessness and refugeeness, the “protection hierarchy”. This norm is in
In this research–in–progress paper, we employ design science research to articulate design knowledge for chatbots in higher education practice. We conducted a literature review to factor previous research into the design process. In addition, we performed a content analysis of student e-mails and forum posts from four instances of a basic Java programming course. Drawing from literature and data,
Motivated by the need for realistic, dynamically self-consistent, evolving galaxy models that avoid the complexity of full, and zoom-in, cosmological simulations, we have developed Nexus, an integral framework to create and evolve synthetic galaxies made of collisionless and gaseous components. Nexus leverages the power of publicly available, tried-and-tested packages: the stellar-dynamics, action
Chromosomal aneuploidy, that is, numerical chromosome aberrations, is one of the molecular hallmarks of cancer. However, when neoplasms are studied with sequencing- and array-based approaches, chromosome numbers and ploidy states are typically inferred from bulk DNA data. Furthermore, published molecular estimates of neoplasia-associated aneuploidy often also include genomic imbalances resulting f
The purpose of the presented garbage collector interface is to provide a universal interface for many different implementations of garbage collectors. This is to simplify the integration and exchange of garbage collectors, but also to support incremental, non-conservative, and thread safe implementations. Due to the complexity of the interface, it is aimed at code generators and preprocessors. Exp
