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The complement system is an arm of innate immunity that aids in the removal of pathogens and dying cells. Due to its harmful, pro-inflammatory potential, complement is controlled by several soluble and membrane-bound inhibitors. This family of complement regulators has been recently extended by the discovery of several new members, and it is becoming apparent that these proteins harbour additional
Background Semaglutide is a novel glucagon-like peptide-1 (GLP-1) analogue, suitable for once-weekly subcutaneous administration, in development for treatment of type 2 diabetes. We assessed the efficacy and safety of semaglutide versus the dipeptidyl peptidase-4 (DPP-4) inhibitor sitagliptin in patients with type 2 diabetes inadequately controlled on metformin, thiazolidinediones, or both. Method
Introduction: Shorter, anatomically shaped and proximally loading stems have been developed to achieve better stress distribution and be more bone preserving. The purpose of this prospective study was to evaluate the migration pattern of the Proxima™ ultra-short uncemented stem using radiostereometric analysis (RSA), and to review the literature regarding the migration of short stemmed hip arthrop
The price of housing in Sweden has, over the past couple of decades, increased at a much faster rate than salaries. Politicians have tried to steer the housing market towards the provision of affordable housing, but have not succeeded. After 1993, the responsibility for regulating the price of housing transferred to the market, which is more interested in building for high-income earners. Despite
The project combines the highly sensitive salt(NaCl) dosemeter for photon radiation with a neutronphotonconverter in the form of thin gadolinium foilsenclosing the salt. Using an identical salt dosemeter butwithout gadolinium cover determines the primaryphoton contribution. With these twin dosemeters placedin a polyethylene sphere, both photon and neutron dosecontributions can be estimated. This p
Design of discontinuity regions in reinforced concrete is today often performed with Strut and Tie Method (STM) or linear finite element analyses (LFEA). However, it is questionable to what extent these design methods are appropriate with regard to resistance, ductility, serviceability and economic reinforcement arrangement. In design with STM a simple equilibrium model based on plasticity theory
The objective of this study was to calculate the long-term risk of accomplished suicide in anxiety disorders, and to compare this with a healthy population. The Lundby Study is a prospective, longitudinal cohort study on a population of 3,563 subjects. Between 1947 and 1997, anxiety disorders were diagnosed in 300 subjects. Up to 2011 there were 68 suicides in all. The suicide risk was 3.3% for an
Helicobacter pylori is a gram-negative spiral-shaped bacterium that colonizes the human stomach and causes gastric inflammation, gastric and duodenal peptic ulcers, gastric cancer and MALT-lymphoma. A novel guinea pig model of H. pylori infection was developed. Infection was induced by oral inoculation and was confirmed by cultivation from the stomach mucosa. The infection led to severe gastric in
The composition of the labour force is an important economic factor for a country. Often the changes in proportions of different groups are of interest. In this paper we study a monthly compositional time series from the Swedish Labour Force Survey from 1994 to 2005. Three models are studied: the ILR-transformed series, the ILR-transformation of the compositional differenced series of order 1, and
Remote sensing is used by the Department of Environment, Climate change and Water (DECCW) for mapping and monitoring the extent of woody vegetation in the State of New South Wales (NSW). In the past DECCW has relied solely on Landsat imagery to provide for these requirements but the need to map woody vegetation change in landscapes such as open woodlands with scattered trees, grasslands, and highl
Self-tuning control of the dissolved oxygen concentration has been tested in full scale at the Käppala Sewage Works at Lidingö, Sweden. The controller has been shown to be robust during varying operating conditions. It also gives the potential for the estimation of interesting variables, such as the oxygen uptake rate. A number of water quality variables have been examined. Interesting couplings b
This paper explores the use of spreadsheets in budgeting in order to explain how and why spreadsheets are used or not used in budgeting practice. Guided by modern budgeting research, budgeting is considered as a social phenomenon which requires flexibility for decision-making and integration for management control. Twenty-one interviews with business controllers in eleven leading for-profit organi
Water vapor sorption isotherms are essential data in models to predict the service life of the cement based structures. The knowledge about sorption isotherms in the presence of supplementary cementitous materials (SCMs) is limited. This study investigates the influence of water to cement ratio (0.4, 0.5 and 0.6), and the presence of two SCMs (70% slag and 10% silica fume) on sorption isotherm in
n this paper a hardware architecture for an OFDM synchronizer is presented. The proposed synchronization unit can be used in any OFDM system that uses a cyclic prefix. The algorithm is based on the correlation introduced by the cyclic prefix, which is exploited in the time domain where both time and frequency offset are estimated simultaneously. The synchronization unit also performs frequency cor
Mid-infrared polarization spectroscopy (IRPS) was applied to detect HCl in flames. For the first time, sensitive and nonin trusive HCl detection with a manner of high spatial- and temporal-resolution in harsh reactive gas flow has been demonstrated in this work. In an atmospheric pressure premixed CH4/O-2/Ar flat flame, trace level HCl was prepared by seeding small amount chloroform through the Ar
The atrial activity of the human heart is normally visible in the ECG as a P-wave. In patients with intermittent atrial fibrilation, a different P-wave morphology can sometimes be seen, indicating atrial conduction defects. The purpose of this study was to develop a method to discriminate between such P-waves and normal ones. 20 recordings of each type were used in a classification which, based on
The formation of triblock copolymer/surfactant complexes upon mixing a nonionic Pluronic polymer (PEO-PPO-PEO) with a cationic surfactant, hexadecyltrimethylammonium chloride (CTAC), has been studied in dilute aqueous solutions using small-angle X-ray scattering, static and dynamic light scattering, and self-diffusion NMR. The studied copolymer (denoted P123, EO20PO68EO20) forms micelles with a ra
A 12-year-old girl with multifocal skeletal sclerosis has been investigated. She was BCG vaccinated at birth and developed regional lymphadenitis in her left groin at two months of age. She was healthy until approximately 10 years of age, after which deficient height and weight gain occurred. BCG-itis was diagnosed in skeleton lesions. No evidence of immunodeficiency was found in the patient. Afte
