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Preclinical data suggest that chronic stress may cause cellular damage and mitochondrial dysfunction, potentially leading to the release of mitochondrial DNA (mtDNA) into the bloodstream. Major depressive disorder has been associated with an increased amount of mtDNA in leukocytes from saliva samples and blood; however, no previous studies have measured plasma levels of free-circulating mtDNA in a
Objectives: To explore reasons for institutionalization of people with dementia according to informal caregivers as well as variation in reasons between countries. Design: An explorative cross-sectional study was conducted in 8 European countries. Setting: Per country, a minimum of 3 long term care facilities, offering care and accommodation as a package, participated in this study. Participating
Popular Abstract in Swedish Hur framställer Johannesevangeliet Jesus och effekterna av hans gärning med tanke på de universella och inkluderande drag som finns i detta evangelium? Hur förhåller sig dessa inkluderande drag till framställningen i övrigt och till de begränsande och exkluderande drag som också finns där, och hur ska dessa motstridiga drag i evangeliet förklaras? Denna avhandling sökeMy thesis is an analysis of exclusive and inclusive features i the Gospel of John, focusing on the inclusive elements which comprise the world and all its people. These questions are the issue of my thesis: How does the Gospel of John present Jesus and the results of his work with regard to the universal and inclusive features which are in the Gospel? How do they relate to the presentation in gene
Health information system (HIS) refers to a data collection and management system that supports the use of health information for planning, management and decision making. Robust HISs are required for the proper management of health data to produce and share high-quality health information for informing planning and decision making at different levels of the health system. This chapter presents th
Imagination is a human capacity that reproduces and transforms experiences and thoughts. The capacity is manifested in children's pretend play and is an important part of adults' ability to process the past, and to plan the future. A first step in the development of imagination is the ability to represent objects and events and to change these representations into alternatives to reality. For adap
Popular Abstract in Swedish I denna avhandlig undersöks hur mekanisk sträckning påverkar den glatta muskulaturen som omger våra blodkärl. En ökad sträckning av blodkärlen sker till exempel vid högt blodtryck vilket leder till en förändrad struktur av kärlet, så kallad remodellering. Ett annat mekaniskt stimuli utgörs av blodets friktion mot de endotelceller som täcker blodkärlens kontaktyta mot blThe vascular wall has a remarkable capacity to adapt to mechanical forces exerted by the intraluminal blood pressure and flow. This includes rapid change in contractile tone as well as chronic alteration of vessel structure if the stimulus persists. Stretch of the intact blood vessel wall promotes growth and contractile differentiation. The molecular mechanisms involved are not well defined, but c
Popular Abstract in Swedish Avhandlingen handlar om vetenskaplig osäkerhet i policyprocessen, det vill säga när vetenskaplig kunskap om en fråga saknas eller den existerande kunskapen är osäker. Studiens huvudsyfte är att förstå om och hur vetenskaplig osäkerhet påverkar policyprocessen. För att undersöka detta har utvecklingen av den svenska klimatpolitiken från 1975 fram till 2007 studerats. MatThe dissertation is about scientific uncertainty in the policy process, that is when scientific knowledge about an issue is lacking or the existing knowledge is uncertain. The aim of the study is to understand if and how scientific uncertainty affects the policy process. For that purpose, the development of climate change policy in Sweden is studied, from 1975 until 2007. The material studied cons
Brottsbekämpande myndigheter använder sig ibland av okonventionella utredningsmetoder för att tillmötesgå en alltmer komplex brottslighet. Ett exempel på en sådan metod är användningen av provokativa åtgärder, som innefattar hemliga utredningsåtgärder eller brottsprovokationer. Ur ett effektivitetsperspektiv är det obestridligt att tendenser i brottsutvecklingen nödvändiggör mer sofistikerade arbeLaw enforcement authorities occasionally employ unconventional investigative techniques in response to increasingly complex forms of criminality. One such technique is the use of covert and provocative measures, including undercover operations and police incitement. From one standpoint of effectiveness, it is indisputable that developments in criminal activity necessitate increasingly sophisticate
BACKGROUND: ATOR-1017 (evunzekibart) is a human agonistic immunoglobulin G4 antibody targeting the costimulatory receptor 4-1BB (CD137). ATOR-1017 activates T cells and natural killer cells in the tumor environment, leading to immune-mediated tumor cell death.METHODS: In this first-in-human, multicenter, phase I study, ATOR-1017 was administered intravenously every 21 days as a monotherapy to pati
PURPOSE: To examine sex differences in health-related quality of life (HRQoL) among patients surgically treated for renal cell carcinoma (RCC) in Sweden, utilizing data from the National Swedish Kidney Cancer Register (NSKCR).METHODS: In this study of 4658 surgically treated RCC patients, data on HRQoL, clinical, demographic, and socioeconomic characteristics were retrieved from the NSKCR for pati
Since mathematical sociology was firmly established in the 1960s, it has grown tremendously. Today it has an impressive scope and deals with topical problems of social structure and social change. A distinctive feature of today's use of mathematics in sociology is the movement toward a synthesis between process, structure, and action. In combination with an increased attention to social mechanisms
There is growing evidence that a significant share of global food is thrown away, with concomitant detrimental repercussions for sustainability. Reducing food waste is a key sustainability challenge for the food service industry. Despite the significance of this issue to the global foodservice industry, the link between innovation practices and food waste management has received limited attention
Introduction: Both decreased levels of brain-derived neurotrophic factor (BDNF) and hypothalamic–pituitary–adrenal (HPA) axis dysregulation may be involved in the pathophysiology of suicidal behaviour, as well as cognitive symptoms of depression. Pre-clinical and clinical studies have shown interactions between HPA-axis activity and BDNF, but this has not been studied in a clinical cohort of suici
Aim: The aim of this study was to evaluate the therapeutic efficacy and safety profile of orally administered low-dose ketamine for procedural pain management in pediatric cancer patients undergoing lumbar puncture (LP) in a resource-limited hospital setting. Methods: Patients between 4 and 15 years of age, with leukemia, undergoing LP were asked to participate. The study was designed as a t
Klimatförändringarna är en av de största samhällsutmaningarna i vår tid och det ställs därför högre av på dagens byggande och materialval. Cirka en femtedel av Sveriges utsläpp kommer från byggbranschen där materialtillverkning och produktionsutsläpp inkluderas. För att minska klimatpåverkan kan strategiska materialval göras för att sänka koldioxidutsläppen. Många gånger görs detta genom att tittaClimate change is one of the biggest societal challenges of our times, which is why high standards are set on today’s building construction and material choices. Around one fifth of the total carbon emissions from Sweden comes from the construction industry where material manufacturing and production are included. Through strategic material choices, could the carbon emissions be reduced. This is o
BackgroundEarly Absenteeism Guide for Lifelong Education (EAGLE) is an early, school-based intervention designed to help school personnel address emerging school absenteeism. EAGLE aims to support early identification, strengthen school–parent collaboration, and guide parents in managing school attendance through a holistic assessment framework.ObjectiveThis qualitative exploratory study investiga
