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PURPOSE: There is hope for neural stem and progenitor cells (NSPC) to enhance regeneration when transplanted to the injured brain after traumatic brain injury (TBI). So far, the therapeutic effects of NSPC transplantation have been hampered mainly by the notable death of the transplanted cells. Neuroinflammation may lead to additional cell death after TBI and we hypothesized that survival of graft
The n = 0 transition multiplet connecting the lowest quartet states of doubly excited C IV has been studied by beam-foil spectroscopy. The fine structure splittings obtained for the 1s2s2p 4p0and 1s2p2 4p terms confirm previous experimental results with an improved accuracy. The average transition wavelength = (1344.49 0.04)A is now more precisely determined by about a factor of eight. At the new
Characterization of land cover change in the past is fundamental to understand the evolution and present state of the Earth system, the amount of carbon and nutrient stocks in terrestrial ecosystems, and the role played by land-atmosphere interactions in influencing climate. The estimation of land cover changes using palynology is a mature field, as thousands of sites in Europe have been investiga
Explaining the ∼5-million-year delay in marine biotic recovery following the latest Permian mass extinction, the largest biotic crisis of the Phanerozoic, is a fundamental challenge for both geological and biological sciences. Ocean redox perturbations may have played a critical role in this delayed recovery. However, the lack of quantitative constraints on the details of Early Triassic oceanic an
In their comment piece, van Basshuysen and Brandstedt raise three main issues: first, whether population at the global scale, or individual family planning decisions, are relevant for climate change mitigation; second, they offer useful critiques of the methodologies to attribute greenhouse gas emissions for the choice to have a child; and third, they question the appropriate ethical responsibilit
The complexity and scales of the processes that shape communities of marine benthic macroinvertebrates has limited our understanding of their assembly mechanisms and the potential to make projections of their spatial and temporal dynamics. Individual-based models can shed light on community assembly mechanisms, by allowing observed spatiotemporal patterns to emerge from first principles about the
Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click
OBJECTIVE. Newborns routinely receive vitamin K to prevent vitamin K deficiency bleeding. The efficacy of oral vitamin K administration may be compromised in infants with unrecognized cholestasis. We aimed to compare the risk of vitamin K deficiency bleeding under different propylactic regimens in infants with biliary atresia. PATIENTS AND METHODS. From Dutch and Danish national biliary atresia re
The influence of the sintering temperature on the mechanical properties of cBN-based ceramic composites with binders in form of vanadium compounds is investigated by methods of physical material science. Two compositions are selected for the study cBN–VC–Al and cBN–VN–Al with 60% vol. of cBN. Samples are obtained by high pressure high temperature sintering (HPHT) in toroid type apparatus with cent
We argue that the neoliberal tradition and new public management reforms of the public sector effectively erode the core (liberal) democratic values of the rule of law and transparency. The tension between public law and managerially-influenced governmental policy is in practice resolved by the emergence of what we call “shadow management” in public administration, whereby managerial decisions tha
This paper discusses rock art in southern Scandinavia as a multisensory format, where both sight and touch would have contributed to the comprehension of the images. From a structural semiotic point of view, we suggest that rock art can be construed as an organised set of features, such as visual and tactile elements, organised into heterogeneous unities with dynamic relations between elements tha
Objective: Epidemiological studies have found air pollution to be a driver of adverse pregnancy outcomes, including gestational diabetes, low term birth weight and preeclampsia. It is unknown what biological mechanisms are involved in this process. A first trimester trophoblast cell line (HTR-8/SVneo) was exposed to various concentrations of PM2.5 (PM2.5) in order to elucidate the effect of urban
Background: In emergency department (ED) chest pain patients, it is believed that the diagnostic accuracy of the electrocardiogram (ECG) for acute coronary syndrome (ACS) is higher during ongoing than abated chest pain. Objectives: We compared patient characteristics and the diagnostic performance of the ECG in ED patients presenting with ongoing, vs. abated, chest pain. Methods: In total, 1132 un
The behavior of 118 spruce bark beetles, Ips typographus, was observed on trees under colonization. Most individuals were followed from when they landed until they entered or left the tree. Both males and females spent most time inspecting crevices and searching for a place to start boring or for a hole to enter. These behaviors accounted for 87 and 70% of all behavioral acts recorded for males an
Two rings of pheromone-baited sticky traps surrounded the elm wood at 20-300m and 1-2km outside the forest edge. Most Scolytus were caught at sites in the inner ring near the forest; <1% of the total were caught in the outer ring. Emergence from logs and trap catches showed a first peak in July. Flight activity was recorded from the end of May to September for both species. A 2nd peak of activity
The Silurian was a time of major climatic transition punctuated by multiple biotic crises and global carbon cycle perturbations. The most severe of these biotic events was the late Silurian (Ludfordian) Lau/Kozlowskii extinction event (LKE) and the associated Lau carbon isotope excursion (CIE). Although the extinction event and Lau CIE are globally documented, the only records thus far of local an
Little is known about the demographic/life-style/physiological determinants explaining the variation of serum perfluoroalkyl acid (PFAA) concentrations in children. We identified significant determinants in children and investigated the influence of low-level PFAA-contaminated drinking water (DW) (<10 ng L-1 of single PFAAs) on serum concentrations. Four perfluorosulfonic acids (PFSAs) and 11 perf
BACKGROUND: Measuring emotional status objectively is challenging, but voice pattern analysis has been reported to be useful in the study of emotion.OBJECTIVE: The purpose of this pilot study was to investigate the association between specific sleep measures and the change of emotional status based on voice patterns measured before and after nighttime sleep.METHODS: A total of 20 volunteers were r
The high substrate variability and complexity of fermentation media derived from lignocellulosic feedstock affects the concentration profiles and the length of the fermentation. Failing to account for such variability raises operational and scheduling issues and affects the overall performance of these processes. In this work, a hybrid soft sensor was developed to monitor and forecast the evolutio
Background. Central arterial stiffness is a surrogate of cardiovascular risk and predicts cardiovascular mortality. Apolipoprotein B lipoproteins are also established cardiovascular risk factors. It is not known whether specific lipoprotein subclasses measured in the Malmö Diet and Cancer Study and previously shown to be associated with coronary heart disease also predict arterial stiffening after
