Sökresultat

Background: MRI is used to evaluate structural joint changes after anterior cruciate ligament (ACL) injury, but no long-term data are available for comparing different treatment approaches. Purpose: To describe structural joint damage with MRI over a 5-year period in the Knee Anterior Cruciate Ligament, Nonsurgical versus Surgical Treatment (KANON) study and to compare frequencies of such tissue d

Aim: This study aimed to identify from different stakeholders the benefits and obstacles of implementing precision medicine in diabetic kidney disease (DKD) and to build consensus about a way forward in order to treat, prevent, or even reverse this disease. Methods: As part of an ongoing effort of moving implementation of precision medicine in DKD forward, a two-day consensus-building meeting was

The scan-on-receive (SCORE) is a key digital beamforming (DBF) technique for future high-resolution wide-swath synthetic aperture radar (SAR) systems. A sharp and high gain receive beam, steered in real time towards the expected direction of arrival (DoA) of the backscattering signal, allows for improved SAR imaging performance with respect to a conventional approach. Nevertheless, it also exposes

The CO2 efflux from soil (soil respiration (SR)) is one of the largest fluxes in the global carbon (C) cycle and its response to climate change could strongly influence future atmospheric CO2 concentrations. Still, a large divergence of global SR estimates and its autotrophic (AR) and heterotrophic (HR) components exists among process based terrestrial ecosystem models. Therefore, alternatively de

AIMS: Heart failure (HF) is a common disease with increasing prevalence and poor prognosis. The vasopressin (VP) marker copeptin predicts development of diabetes mellitus, diabetic heart disease, coronary artery disease, and premature mortality. Copeptin is elevated in HF patients and predicts a worse outcome. This study aims to investigate whether copeptin can predict HF development.METHODS: Cope

Atmospheric inversions are used to derive constraints on the net sources and sinks of CO2 and other stable atmospheric tracers from their observed concentrations. The resolution and accuracy that the fluxes can be estimated with depends, among other factors, on the quality and density of the observational coverage, on the precision and accuracy of the transport model used by the inversion to relat

PURPOSE To estimate age-specific relative and absolute cancer risks of breast cancer and to estimate risks of ovarian, pancreatic, male breast, prostate, and colorectal cancers associated with germline PALB2 pathogenic variants (PVs) because these risks have not been extensively characterized. METHODS We analyzed data from 524 families with PALB2 PVs from 21 countries. Complex segregation analysis

Prior results on target localization and circumnavigation with bearing measurements in $\mathbb {R}^{2}$ are extended with integral action, resulting in a control system that is robust to bounded load disturbances on the control inputs. Such disturbances may arise in practice due to modeling errors and need to be considered to ensure small tracking errors. The control inputs are modeled as the sys

This work considers direction-finding using a monostatic multiple-input multiple-output (MIMO) radar in the presence of impulsive noise. Employing a novel low-order covariance-based exponential kernel function, the proposed maximum likelihood (ML) formulation exploits an introduced quantum whale optimization algorithm (QWOA) to form the direction estimates. The resulting estimates are shown to be

This is a comment on the review by Korolev and Leisner (2020, hereafter KL2020). The only two laboratory/field studies ever to measure the breakup in ice-ice collisions for in-cloud conditions were negatively criticised by KL2020, as were our subsequent theoretical and modelling studies informed by both studies. First, hypothetically, even without any further laboratory experiments, such theoretic

Jump models switch infrequently between states to fit a sequence of data while taking the ordering of the data into account We propose a new framework for joint feature selection, parameter and state-sequence estimation in jump models. Feature selection is necessary in high-dimensional settings where the number of features is large compared to the number of observations and the underlying states d

Understanding the loss surface of neural networks is essential for the design of models with predictable performance and their success in applications. Experimental results suggest that sufficiently deep and wide neural networks are not negatively impacted by suboptimal local minima. Despite recent progress, the reason for this outcome is not fully understood. Could deep networks have very few, if

Background: Treatment of mentally disordered offenders (MDOs) is challenging as their behavior and clinical conditions can be traced to a complex constellation of major mental disorders, substance use and antisocial lifestyle. Finding subgroups of these offenders, which could guide treatment and risk assessment, is desirable. There are few long-term, prospective studies of risk factors for persist

We present inverse modelling (top down) estimates of European methane (CH4) emissions for 2006–2012 based on a new quality-controlled and harmonised in situ data set from 18 European atmospheric monitoring stations. We applied an ensemble of seven inverse models and performed four inversion experiments, investigating the impact of different sets of stations and the use of a priori information on e

We derive an expression for the error introduced by the second-order accurate temporal finitedifference (FD) operator, as present in the FD, pseudospectral and spectral element methods for seismic wave modeling applied to time-invariant media. The 'time-dispersion' error speeds up the signal as a function of frequency and time step only. Time dispersion is thus independent of the propagation path,

The protection of trade secrets in Portugal and Spain has been derived from general legal principles (of Civil Law, Penal Law and Unfair Marketing Law). This chapter on implementation of the Trade Secrets Directive (TS Directive) in Portugal and Spain presents the traditional views and positions and the implementation of the TS Directive into the respective national legal orders.In Portugal, imple

Questions: We investigated the changing role of climate, forest fires and human population size in the broad-scale compositional changes in Holocene vegetation dynamics before and after the onset of farming in Sweden (at 6,000 cal yr BP) and in Finland (at 4,000 cal yr BP). Location: Southern and central Sweden, SW and SE Finland. Methods: Holocene regional plant abundances were reconstructed usin

Background: Fetal cardiovascular magnetic resonance (CMR) imaging may provide a valuable adjunct to fetal echocardiography in the evaluation of congenital cardiovascular pathologies. However, dynamic fetal CMR is difficult due to the lack of direct in-utero cardiac gating. The aim of this study was to investigate the effectiveness of a newly developed Doppler ultrasound (DUS) device in humans for

Traditional matrix factorization methods approximate high dimensional data with a low dimensional subspace. This imposes constraints on the matrix elements which allow for estimation of missing entries. A lower rank provides stronger constraints and makes estimation of the missing entries less ambiguous at the cost of measurement fit. In this paper we propose a new factorization model that further