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Recent genome-wide association studies have described many loci implicated in type 2 diabetes (T2D) pathophysiology and beta-cell dysfunction but have contributed little to the understanding of the genetic basis of insulin resistance. We hypothesized that genes implicated in insulin resistance pathways might be uncovered by accounting for differences in body mass index (BMI) and potential interact

The functional significance of fibrin deposits typically seen in inflammatory lesions, carcinomas and in healing wounds is not fully understood. In the present study, we demonstrate that fibrinogen/fibrin specifically bound to native Col I (collagen type I) and used the Col I fibre network as a base to provide a functional interface matrix that connects cells to the Col I fibres through alpha V be

By using a Swern oxidation-epimerization-reduction sequence it is possible to selectively epimerize any position in isopropylidene-protected xylopyranosides, thus forming arabinosides, ribosides, and lyxosides. The driving force for epimerization of position 3 (xylo to ribo) is the release of ring strain by going from a 1,2-trans-acetal to a 1,2-cis-acetal.

Chromosomal instability is a known hallmark of many cancers. DNA polymerases represent a group of enzymes that are involved in the mechanism of chromosomal instability as they have a central function in DNA metabolism. We hypothesized that genetic variation in the polymerase genes may affect gene expression or protein configuration and by that cancer risk and clinical outcome. We selected four gen

Background: Negative pressure wound therapy (NPWT) has remarkable effects on the healing of poststernotomy mediastinitis. Foam is presently the material of choice for NPWT in this indication. There is now increasing interest in using gauze, as this has proven successful in the treatment of peripheral wounds. It is important to determine the effects of NPWT using gauze on heart pumping function bef

Abstract Aim: The aim of the thesis was to evaluate the use of advanced MRI technology to improve results of epilepsy surgery, with focus on language and memory functions. Methods: In paper I, 25 patients with drug-resistant epilepsy were retrospectively included in the study for having been referred to high resolution 3T MRI with and without surface coils. The surface coils were placed over the s

Pupils tend to experience ‘attentional fatigue’ after persistently demanding their attentional system during school hours, resulting in decreased psychological well-being and a lack of attention, along with losses of other cognitive functions. Previous research found natural elements in a school environment to restore pupils’ depleted attentional system. The present study aimed at investigating na

Facing the challenges of climate change and energy depletion, the world needs to deploy more renewable energy to replace fossil fuels. As the largest energy consumer and carbon emitter, China’s sustainable energy transition is particularly important. Owning the vast offshore wind (OW) resources, the Chinese Government has set ambitious goals on OW that provides a reliable and reasonable alternativ

AI-systemens snabba utveckling har på senare år fört teknologin till nya höjder. Framväxten av autonoma fordon och avancerade språkmodeller som ChatCPT har ställt diskussionen kring AI-systemens rättsliga problematik på sin spets. Bland annat har skadeståndsrättens reparativa syfte blivit svårare att uppnå till följd av att skador orsakade av AI-systemen komplicerar preciseringen av ansvarande paIn recent years, the rapid development of AI systems has elevated the technology to new heights. The emergence of autonomous vehicles and advanced language models like ChatCPT has brought the discussion around the legal issues of AI systems to the forefront. The primary aim of tort law is to compensate the injured parties and impose liability on the parties responsible. Due to the complex nature

This study aims to examine how the sensitivity for macroeconomic announcements surprises changes for the exchange rate in terms of a crisis. Previous research has been biased for U.S announcements and their relation towards emerging market, which has shown that U.S announcements affect more than the domestic. It also suggests that business cycle and uncertainty affect and increase the reaction for

Regelverk på nationell och internationell nivå som syftar till att uppmuntra och underlätta internationella investeringar och handel möjliggör idag för multinationella företag att verka transnationellt genom användning av filialer och dotterbolag. När det kommer till företagsbeskattning har avsaknaden av ett globalt och universellt skattesystem för att reglera internationella skattefrågor dock möjDomestic and international regulations aiming to facilitate international trade and investment today enable multinational corporations (MNCs) to operate transnationally through the use of branches or subsidiary companies. Within the field of corporate taxation, the lack of a global and universal tax system regulating international tax matters however allows MNCs to exploit gaps and loopholes withi

This study explores the Chinese computational propaganda exploitation during the Covid-19 crisis. By demonstrating the intricacies of this case of computational propaganda utilization, this research attempts to answer an even larger question: How do authoritarian countries incorporate computational propaganda to their soft power strategies. To that end, first; a theoretical bridge was formed betwe

While carbon emissions hit an all-time high in 2019 and are expected to grow, it is important to explore strategies for reducing emissions and mitigating climate change. A potential focus for curbing emissions is the flying sector, since air travel is one of the most carbon-intensive activities an individual can engage in. Among air travelers, frequent flyers yield the highest potential for saving

År 2009 reformerades det administrativa förfarandet för tillståndsprövningar av vindkraftverk, delvis för att en större vindkraftsutbyggnad skulle komma till stånd men också som nödvändig en åtgärd för att Sverige skulle uppfylla sina skyldigheter i 2009 års förnybarhetsdirektiv. Tidigare hade en ansökning om att få bygga vindkraft inneburit dubbla process- och tillståndsförfaranden enligt både PlIn 2009 the Swedish legislature regarding the administrative procedure applicable to wind energy projects was amended, in part to increase wind power construction but also as a measure to fulfil Sweden’s obligations stemming from the 2009 Renewables directive. As a result, the dual process- and permit procedure under both the Plan and Building Act and the Environmental Code was abolished. Instead,

The purpose of the thesis was to study the safety and reliability requirements in the automotive industry from a production test perspective. A survey of the requirements in the automotive standard AEC-Q100 was conducted and the implications of compliance with the requirements were analyzed. In addition to this, production data was reanalyzed considering the requirements found in the survey. From

Our world is experiencing accelerated ecological destruction and social injustices on different scales and multiple levels. Unchecked economic growth has been criticised as causing this since the 1970s, but the dominant sustainable development paradigm has perpetuated the belief that economic growth and environmental protection can go hand-in-hand. In response degrowth has emerged in the last deca