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Efficient screening of ligands interacting with G-protein-coupled receptors is central for modern drug development. Here, we describe an optimized reporter vector primarily intended for use in reporter cell lines expressing such receptors. The construct consists of a synthetic enhancer containing 9x TRE (12-O-tetradecanoylphorbol-13-acetate-responsive elements) fused to a minimal CMV (cytomegalovi
Background: Prospective studies have indicated that elevated blood glucose levels may be linked with increased cancer risk, but the strength of the association is unclear. We examined the association between blood glucose and cancer risk in a prospective study of six European cohorts. Methods and Findings: The Metabolic syndrome and Cancer project (Me-Can) includes cohorts from Norway, Austria, an
We report on the development of planar laser-induced fluorescence (PLIF) for CH imaging with improved detection sensitivity for single-shot investigations of turbulent, lean, premixed flames. A ringcavity, pulsed Alexandrite laser was frequency-doubled to excite the lines in the R-branch band-head of the B-X (0,0) band and broadband fluorescence from the B-X (0,1), A-X (1,1) and (0,0) bands, overl
A variant of the cysteine protease inhibitor, cystatin C, forms amyloid deposited in the cerebral vasculature of patients with hereditary cerebral hemorrhage with amyloidosis, Icelandic type (HCHWA-I), leading to cerebral hemorrhages early in life. However, cystatin C is also implicated in neuronal degenerative diseases in which it does not form the amyloid protein, such as Alzheimer disease (AD).
Popular Abstract in Swedish Vård och behandling av akut postoperativ och cancer-relaterad smärta: Patienters erfarenheter och uppfattningar i förhållande till hälsorelaterad livskvalitet och smärtans dimensioner Trots att det finns effektiva behandlingsmetoder för patienter med postoperativ smärta och cancer-relaterad smärta så lider många patienter av smärta. Denna avhandling beskriver patienterThis thesis describes patients in acute postoperative pain as well as patients with acute cancer-related pain in palliative care, and their experiences and perceptions of pain management in relation to HRQOL and the multidimensionality of pain. A combination of qualitative and quantitative methods was chosen. Data were collected using interviews and questionnaires; APS, SF:36 and a new developed q
In this article, we describe a system that classifies relations between entities extracted from an image. We started from the idea that we could utilize lexical and semantic information from text associated with the image, such as captions or surrounding text, rather than just the geometric and visual characteristics of the entities found in the image. We collected a corpus of images from Wikipedi
Sammanfattning Den här uppsatsen handlar om bestämmelsen i 5 kap. 5 § Patientdatalagen (2008:355), PDL, som möjliggör för patienten att läsa sin journal via internet. Uppsatsen handlar även om journalens rättsliga status och ramverk, samt om patientens rätt att ta del av sin journal. Det övergripande syftet med uppsatsen är att undersöka hur datoriseringen av hälso- och sjukvården och dess möjligSummary This essay examines the rule in the Swedish Patient Data Act (Patientdatalagen), which says that it is possible to give the patient access to his/her medical record via the Internet. The aim with the essay is to examine whether the computerization of health care in Sweden has had any impact on the patient’s right to information about his/her medical status. By examining this, the essay an
Background: An Enterprise Resource Planning, ERP, system is an important part of a company and can create competitive advantages. Hence, the reasons for implementing an ERP system are several. However, the comprehensive nature of ERP systems results in complex implementation projects. Problem: A large proportion of ERP implementations fail. Several different Critical Success Factors, CSFs, for ER
Title: HealthBook Sub title: Integrated End-User Device for Rural Health Workers in Low Resource Settings Author: Johan Larsson Supervisor: Goirgos Nikoleris, Machine Design Secondary supervisor: Rustam Nabiev, Karolinska University, MTA R&D Examiner: Robert Bjärnemo, Machine Design Introduction: This thesis is part of a project called ICT4MPOWER with the purpose to solve the problem with med
Denna uppsats fokuserar på idrottens spelaravtal och inriktar sig särskilt på dess avtalstolkning. För en djupare förståelse kring spelaravtalets bakgrund och kontext behandlar uppsatsen idrottsjuridiken som ett internationellt fenomen. Med detta i beaktande sker en betydande jämförelse mellan svensk och angloamerikansk rätt, men även en fördjupning kring angloamerikansk påverkan inom ramen för spThis thesis focuses on player’s contracts, and in particular the interpretation of such contracts. In order to deepen the understanding of the background and context of the player’s contracts, this thesis will treat sports law as an international phenomenon. With the internationalisation in consideration, there will be a comparison between Swedish and Anglo-American law, and also further discussio
I Sverige uppskattas den offentliga upphandlingen omsätta omkring 500 miljoner kronor per år. Dessa stora ekonomiska värden ger det offentliga makt att påverka privata aktörer och gör att upphandling kan bli ett viktigt politiskt styrmedel. I vilken utsträckning socialpolitiska målsättningar ska kunna främjas genom offentlig upphandling har dock varit föremål för diskussion. I den här uppsatsen haIn Sweden, public procurement annually accounts for approximately SEK 500 million. With these large economic values, the public has the power to influence private actors. In this way, procurement can be an important policy tool. To what extent public procurement can be used to promote social objectives has been subject to discussion. In this essay, I have chosen to investigate the scope provided f
Background: The influence of daily life exposure on the gastrointestinal tract is not fully understood. This study aimed to examine associations between functional gastrointestinal symptoms and sociodemographic status and lifestyle habits in the general population. Methods: The Malmö Offspring Study (MOS) included 2,648 participants from the general population who had answered a questionnaire abou
1,2-Addition of 3,4-methylenedioxymagnesium bromide to 2-(R) and (S)-benzyloxy-2,5-dihydro-4-furancarboxaldehyde, followed by oxidation, gave the title ketones (3r and 3s). Conjugate addition of the anions of 3,4,5-trimethoxy- and 3,4-methylenedioxybenzaldehyde diphenylthioacetal to 3r and 3s and Raney-nickel desulfurisation, followed by hydrogenolysis under various conditions, gave the title lign
OBJECTIVE: This study used meta-analysis to assess disparities in cardiovascular disease (CVD) screening and treatment in people with mental disorders, a group that has elevated CVD incidence and mortality. METHODS: The authors searched PubMed and PsycInfo through July 31, 2020, and conducted a random-effect meta-analysis of observational studies comparing CVD screening and treatment in people wit
For diagnosis and risk assessment in patients with stable ischemic heart disease, myocardial perfusion scintigraphy is one of the most common cardiological examinations performed today. There are however many motivations for why an artificial intelligence algorithm would provide useful input to this task. For example to reduce the subjectiveness and save time for the nuclear medicine physicians wo
Background: Primary spinal tumors are rare. Symptoms depend on the size and location of the tumor.Case description: A patient presented with a rare clinical finding, Brown-Séquard syndrome. The symptoms were caused by an extramedullary tumor compressing on the thoracic spinal cord. Pathologic examination showed cavernous hemangioma with growth both intradurally and extradurally.Conclusions: This i
Europe has experienced severe drought events in recent decades, posing challenges to understand vegetation responses due to diverse vegetation distribution, varying growth stages, different drought characteristics, and concurrent hydroclimatic factors. To analyze vegetation response to meteorological drought, we employed multiple vegetation indicators across European biomes. Our findings reveal th
CEO compensation is a contested topic in business research, shaped by several determinants. One such factor is CEO visibility, which prior research has linked to CEO compensation in traditional media settings. However, it remains unclear whether this visibility-compensation relationship extends to professional social media platforms (PSMPs). This study examines whether CEO PSMP visibility is assoc
FACULTY OF MEDICINE | LUND UNIVERSITY LAST UPDATED 2020-09-08 Regulations for the Programmes in Biomedicine 1 Programmes in Biomedic ine Regulations for applications to the Student Welfare Committee (Studiesociala kommittén) within the Master’s Programmes Board (PNM) regarding the Bachelor’s Programme in Biomedicine and the Master’s Programme in Biomedicine These regulations were decided upon by t
Dean Contact details Email: henrik [dot] wenander [at] jur [dot] lu [dot] se Phone: +46 46 222 11 13Organisation Faculty of Law Room number: 511 Service point: 56 WebpageHenrik Wenanders profile in Lund University research portalOther affiliations Chair Faculty Board of Law Research coordinator Public Law Professor Department of Law Publications Displaying of publications. Sorted by year, then tit
https://www.law.lu.se/henrik-wenander - 2026-07-22
