Filtyp
Structure-based protein design offers a possibility of optimizing the overall shape of engineered binding scaffolds to match their targets better. We developed a computational approach for the structure-based design of repeat proteins that allows for adjustment of geometrical features like length, curvature, and helical twist. By combining sequence optimization of existing repeats and de novo desi
Viruses may be part of the pathogenesis of rheumatoid arthritis (RA). Double stranded RNA (dsRNA) is a prototypic viral conformation of nucleic acid that is highly arthritogenic in mice. Therefore, we developed an ELISA to detect dsRNA in sera and synovial fluids (SF) in RA patients and in osteoarthritic controls. The developed ELISA recognizes picogram levels of viral or synthetic dsRNA but shows
Radiative lifetime measurements were performed with time-resolved laser-induced fluorescence techniques for 24 levels of Nd II in the energy range 20 500- 32 500 cm(-1). For 17 levels, no previous experimental data exist. These results have allowed the testing of new theoretical calculations with the relativistic Hartree-Fock method taking configuration interactions and core-polarization effects i
The detection of the formyl radical (HCO) is of great interest in the field of combustion research since it can provide information about the local heat release (HR) rate which is a key parameter in the understanding of combustion processes. Unfortunately, due to the low signal level, HCO planar laser-induced fluorescence (PLTF) has so far not been applicable for single-shot imaging, which is nece
The Chemotaxis Inhibitory Protein of Staphylococcus aureus (CHIPS) binds and blocks the C5a receptor (C5aR) and formyl-peptide receptor (FPR). This way, CHIPS is a potent inhibitor of the immune cell recruitment associated with inflammation. Truncation of the protein and the introduction of mutations, shifts the expression towards the insoluble fraction of Escherichia coli, whereas the wild-type p
Complex traits, including inflammatory rheumatic diseases, have important genetic features, but most of the responsible genes have not been conclusively identified. Genetic analysis of inbred animal models and comparative genetics - the comparison of genes between different species - might help to identify the crucial genes and to investigate more directly the biology involved. Genome-wide linkage
Adult patients with hematologic malignancies along with HIV infected patients were prospectively studied to determine the performance of urine D-arabinitol/L-arabinitol (DA/LA) ratio in diagnosing invasive candidiasis. Ten evaluable febrile neutropenic patients had proven invasive candidiasis and elevated DA/LA ratios were found in 5. Invasive candidiasis with normal DA/LA ratios was most frequent
This chapter focuses mainly on quality and a frame of reference to understand M-learning dimension concerns as course design, learning design, and media design and content. Consistent layout and design, clear organization, and presentation of information, consistency, easy-to-use navigation, and aesthetically pleasing design and graphics are dimensions that also have to be taken into consideration
Many of society’s critical infrastructures, such as power supply, telecommunications, and transportation, have become increasingly interconnected. While this gives rise to increased efficiency, tighter connections also invites increased vulnerability and the risks of cascading failures. Moreover, at the same time as many of these vital systems have become increasingly dependent on one another, the
Although it is generally anticipated that innovation as such leads to regional prosperity (Asheim et al. 2011) there is lack of empirical evidence that confirms the direct linkage between the innovation capabilities of regions and welfare increase. It is suggested that entrepreneurship can be seen as a missing link that helps to transfer innovations into business outcomes (Braun et al. 2012). The
Popular Abstract in Swedish Är ledgångsreumatism en immunreaktion mot brosk? Kroppens immunförsvar bygger på ett antal olika vita blodkroppar, immunceller, som cirkulerar i blod och lymfa på spaning efter främmande och farliga "angrepp". Immuncellerna sägs svara på "angrepp", sådana immunsvar dirigeras av s k T-hjälparceller (Th-celler). Th-cellerna kommer från benmärgen, men de blir inte funktioThis thesis is based on work trying to understand the normal and pathological interactions taking place between the immune system and cartilage, specifically involving the cartilage-specific protein typ II collagen (CII). The work has been carried out in an experimental model of rheumatoid arthritis namely collagen type II induced arthritis (CIA) in mice. CIA can be triggered in mice of certain MH
After a brief introduction (1) this chapter covers: (2) optical tweezers and related techniques, (3) uses of lasers for ablation, desorption, ionization, and dissection, (4) fluorescent labeling, (5) Abbe's diffraction limit to spatial resolution in microscopy, (6) two-photon excitation fluorescence microscopy, (7) stimulated emission depletion (STED), (8) near-field microscopy, (9) quantum dots a
Abstract is not available
The author analyses the business model of Application Service Provider (ASP) as a less material intensive alternative to traditional computing - a promising example of ICT sector dematerialisation. The article compares the ASP vs. traditional computing models from environmental and business perspectives. The ASP service model has a potential to provide both economic and environmental benefits. By
Euro50 is a proposed optical telescope with an equivalent primary mirrordiameter of 50 m. Partners of the collaboration are institutes inSweden, Spain, Ireland, Finland, and the UK. The telescope will have asegmented primary mirror and an aplanatic Gregorian configuration withtwo elliptical mirrors. For a 50 m telescope there would be noeconomical advantage in going to a spherical primary. The siz
Experimental and numerical investigations of the ignition of hydrogen/air mixtures by jets of hot exhaust gases are reported. An experimental realisation of such an ignition process, where a jet of hot exhaust gas impinges through a narrow nozzle into a quiescent hydrogen/air mixture, possibly initiating ignition and combustion, is studied. High-speed laser-induced fluorescence (LIF) image sequenc
Over the last ten years, there has been a great deal of research and development in Sweden in the field of rehabilitation robotics. The research effort has often focused on workplace adaptations. This paper deals with four robotic adaptations, all of whic
