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We created a system to simulate the heart allocation process in a transplant queue, using a discrete event model and a neural network algorithm, which we named the Lund Deep Learning Transplant Algorithm (LuDeLTA). LuDeLTA is utilized to predict the survival of the patients both in the queue and after transplant. We tried four different allocation policies: wait time, clinical rules and allocating
Purpose: The aim was to evaluate the impact of age-appropriate information and preparation procedures for children with cancer undergoing radiotherapy on 1) parents and family functioning, parents' anxiety and 2) hospital costs compared to traditional care. Design and Methods: An un-matched quasi-experimental controlled clinical trial was conducted consisting of a control group including 31 parent
BACKGROUND: The minor T allele of rs2943641 near the gene encoding for insulin receptor substrate 1 (IRS1) has been associated with decreased risk of type 2 diabetes (T2D) and adiposity in genome-wide association studies. Dietary intake can influence the regulation of IRS1, and studies have indicated sex-specific associations between IRS1 and adiposity. OBJECTIVE: The objective was to examine the
Swedish filmmaker Jan Halldoff's fiction film Korridoren (The Corridor) premiered in 1968 to a mainly positive Swedish reception. Shot at Karolinska Hospital and criticizing the Swedish healthcare system, the film became much debated and can furthermore be seen as a turning point in Swedish film history regarding the portrayal of medical institutions and professionals. In this article, the film an
The structural research programmes of the European Union dedicated to advance thesustainability sciences are increasingly permeated by thenotion of transdisciplinarity (TD). A growing body of literature residing at the intersection of research methodology and sustainability studies can guide researchers to adopt appropriate research approaches in their projects. However, how to implement the trans
Factor H is an inhibitor of the complement system, essential for controlling the alternative pathway and also playing a crucial role in various cellular functions. In this thesis, we identified new intriguing functions of FH as a survival factor for primary human monocytes, promoting their differentiation into immunosuppressive macrophages. We showed that FH is expressed by human breast cancer cel
Pulmonary arterial hypertension (PAH) is a rare disease that affects the pulmonary vasculature. Characterized by increased pulmonary arterial pressures and vascular resistance, it causes right heart failure (HF), and premature death. The main symptom, exertional dyspnoea, is non-specific where patient’s and doctor’s delay often lead to diagnosis in advanced stages. Despite development of PAH speci
In this paper we propose minimal solvers for relative pose estimation for two views of the projected silhouettes of two 3D cylinders. Using such line features instead of the standard point feature correspondences means more stable information (i.e. more stable to lighting condition, seasons, changes in environment etc.). Such features also lead to more compact and semantically interpretable repres
Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chrom
In this paper, we discuss the pedagogical concepts of socialisation and uncoverage and the theoretical perspective of metanarratives on history and historical concepts as tools to integrate the students of the online Master’s programme Religious Roots of Europe into the practice of the historical study of religion. We describe how we worked in facilitating the typical learning processes
Human-induced impacts are increasing pressure on coastal ecosystems, particularly on benthic ecosystems in high-latitude regions. It has become evident that three of the greatest marine environmental challenges related to anthropogenic activity are warming, ocean acidification, and deoxygenation. The effect of these environmental changes on our uncertain future has created a need to understand the
Background: Ice hockey is played by women and men but the arena they play in may differ substantially. Potential differences in general conditions to play the sport may be associated to perceived stress, which has shown to be related to athletic injury in other sports. Therefore, this study aimed to describe and compare general conditions for playing ice hockey, stress levels, and the association
CONTEXT: The 2 peaks of type 1 diabetes incidence occur during early childhood and puberty.OBJECTIVE: We sought to better understand the relationship between puberty, islet autoimmunity, and type 1 diabetes.METHODS: The relationships between puberty, islet autoimmunity, and progression to type 1 diabetes were investigated prospectively in children followed in The Environmental Determinants of Diab
Background: Nausea and vomiting in pregnancy (NVP) affects 50–80% of pregnant women and is correlated to the level of human chorionic gonadotropin (hCG). Hyperemesis gravidarum (HG) is a severe condition, with an incidence of 0.2–1.5%, characterized by consistent nausea, vomiting, weight loss and dehydration continuing after the second trimester. Aim: The aim of this systematic review was to inves
In this paper we present methods for triangulation of infinite cylinders from image line silhouettes. We show numerically that linear estimation of a general quadric surface is inherently a badly posed problem. Instead we propose to constrain the conic section to a circle, and give algebraic constraints on the dual conic, that models this manifold. Using these constraints we derive a fast minimal
This paper develops a novel sparse direction-of-arrival (DOA) estimation technique that avoids the common requirement of hyperparameters, which are typically difficult to set suitably in practice. Using the presented minimum mean-square error (MMSE) estimation framework, we propose a computationally efficient super-resolution DOA estimator that is implemented using an alternate updating of the spa
In this work, a computationally efficient evolutionary algorithm is proposed for estimating the direction of arrival (DOA) of coherently distributed (CD) sources corrupted by additive impulsive noise. The typical method, such as distributed signal parameter estimation (DSPE) method, requires a 2-D spectral peak search and cannot allow for coherent signals. The proposed method in this article uses
