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Recent studies have identified mutations in the complement regulatory gene factor I (CFI) that predispose to atypical hemolytic uremic syndrome (aHUS). CFI is a two-chain serine protease in which the light chain carries the catalytic domain while the heavy chain's function is unclear. It downregulates the alternative and classical complement pathways by cleaving the alpha' chains of C3b and C4b in

Popular Abstract in Swedish Avhandlingen behandlar det grekiska landskapet Argolis på östra Peloponnesos och vissa aspekter av livet där under drygt 600 år av romersk överhöghet. I området har man från den tiden funnit lämningar av städer, byar, villor och gårdar så väl som speciella anläggningar för framställning av olivolja, vin och keramik, dessutom badanläggningar, akvedukter, stenbrott, hamnaThis study focuses on the region of Argolid in the eastern part of the Greek Peloponnese during the Roman Imperial era, taking up a variety of aspects of life there based mainly on archaeological evidence. The introduction presents the study area and the background to the study. This is followed in the next chapter by a survey of the various kinds of sites of Roman date found in the Argolid. Citie

Popular Abstract in Swedish Det religiösa landskapet i Europa genomsyras av rituell kreativitet - inom teater, psykoterapi och religiösa samfund laborerar individer och grupper med rituella former under mer eller mindre obundna förutsättningar. En stor del av det rituella nyskapandet återfinns emellertid utanför de etablerade religiösa institutionerna och traditionens ortopraxi. Här ses ritualer oRitual creativity may seem like a contradiction in terms, yet the religious landscape in contemporary Euro-America is permeate with experimentation of ritual forms, different modalities of action, imagination and play as routes to authenticity. The present study examines different settings in Europe involved in such ritual creativity, which would commonly be classified as postmodern spirituality,

Development of type-II collagen (CII)-induced arthritis (CIA) is dependent on a T-cell mediated activation of autoreactive B cells. However, it is still unclear if B cells can present CII to T cells. To investigate the role of B cells as antigen-presenting cells (APCs) for CII, we purified B cells from lymph nodes of immunized and nonimmunized mice. These B cells were used as APC for antigen-speci

BACKGROUND: To determine if the common Pro12Ala polymorphism (rs1801282) of the peroxisome proliferator-activated receptor (PPARG) gene is associated with the metabolic syndrome (MetS) or with its individual components in middle-aged Swedish individuals. METHODS: MetS was defined according to the National Cholesterol Education Program/Adult Panel III (NCEP/ATP III), the International Diabetes Fede

Hypothermia has been reported to reduce infarct size (IS) in patients with ST segment elevation myocardial infarction (STEMI). We aimed to confirm the cardioprotective effects of hypothermia using a combination of cold saline and endovascular cooling.

To resist infections, robust defense mechanisms of the airways are essential. Retinoic acid promotes differentiation and maintains the phenotypic characteristics of bronchial epithelium. In addition, it induces the expression of the antibacterial growth factor midkine (MK). In the present study, we explored the expression and antibacterial activity of MK in an airway context. MK was detected in br

InAs/HfO2 nanowire capacitors using capacitance-voltage (CV) measurements are investigated in the range of 10 kHz to 10 MHz. The capacitors are based on vertical nanowire arrays that are coated with an 8 nm-thick HfO2 layer by atomic layer deposition. CV characteristics are measured at temperatures in the range between -140 and 40 degrees C and the CV characteristics for nanowires with different S

The majority of women diagnosed with lymph node-negative breast cancer are unnecessarily treated with damaging chemotherapeutics following surgical resection. This highlights the importance of understanding and more accurately predicting patient prognosis. Here, we define the transcriptional networks regulating well-established prognostic gene expression signatures. We find that the same set of tr

Background Compared with placebo, prophylactic treatment with bisphosphonates reduces risk of skeletal events in patients with multiple myeloma. However, because of toxicity associated with long-term bisphosphonate treatment, establishing the lowest effective dose is important. This study compared the effect of two doses of pamidronate on health-related quality of life and skeletal morbidity in pa

The intestinal microbiota is important for tolerance induction through mucosal immunological responses. The composition of the gut microbiota of an infant is affected by environmental factors like diet, disease and antibiotic treatment. However, already in utero these environmental factors can affect the immunological development of the fetus and influence the future gut microbiota of the infant.

China's transition from planned to market economy is at present one of the topics most discussed among researchers. According to almost any version of mainstream property rights theory, the rapid privatization or what has been described as the "East European model" basically represents the correct approach to transformation, while the gradual transition, or the "Chinese model", should represent a

We have recently generated 5'lambda5-huTAC mice, which express the human CD25 (huTAC) gene under the control of the 5'-flanking region of the mouse lambda5-gene. The huTAC-transgene was expressed in pre-B cells but neither in mature B cells nor in T cells of these mice. In this report we demonstrate that the transgene is also transiently expressed by adult CD25+ CD3-CD4-CD8- (triple negative, TN)

Mucin-1 has proven to be a suitable target for antibody-based diagnosis and therapy of certain tumours, but no appropriate human antibody or antibody fragment displaying slow dissociation rate kinetics against this target is available. Since a rapid dissociation character prevents an antibody fragment from remaining at the site of the antigen, this fact may prevent the successful application of a

The neuronal soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) complex is essential for synaptic vesicle exocytosis, but its study has been limited by the neonatal lethality of murine SNARE knockouts. Here, we describe a viable mouse line carrying a mutation in the b-isoform of neuronal SNARE synaptosomal-associated protein of 25 kDa (SNAP-25) The causative I67T missens

Clinical trials involving intrastriatal transplants of human embryonic mesencephalic tissue have provided proof-of-principle that nigral dopamine (DA) neurons can survive and functionally integrate into the host neural circuitry. However, the degree of graft-induced symptomatic relief differs significantly between the patients. This variability has led to investigations aimed at identifying factor

Lymphatic vessels (LVs) play critical roles in the maintenance of fluid homeostasis and in pathological conditions, including cancer metastasis. Although mutations in ALK1, a member of the transforming growth factor (TGF)-beta/bone morphogenetic protein (BMP) receptor family, have been linked to hereditary hemorrhagic telangiectasia, a human vascular disease, the roles of activin receptor-like kin

Juggling balls’ is a multi-player game that was developed in the form of a Java Applet. The game was developed as part of a software-engineering project. The software itself was designed for the needs of an ongoing research project. The foundation ideas and further development was drawing on a research project which focuses on visualisation in relation to individual emergence in a context of doubl

Among the science challenges of the Extremely Large Telescopes (ELTs),four object types are studied for performance with a 50 m ELT withadaptive optics (AO), Euro50. Emphasis is on planetary systems and verydistant objects. For planetary systems and their evolution, we examinehigh resolution imaging of the nuclei of comets and high-resolutionimaging, photometry and low and intermediate resolution

Staphylococcus aureus enterotoxin H (SEH) belongs to the staphylococcal enterotoxin (SE) family of superantigens (SAgs). SEH has structural similarities to other SE; however, its biological properties are less well characterized. SEH binds with high affinity to human major histocompatibility complex (MHC) class II and exhibits strong mitogenic activity in human T cells, although it was found to be