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Rare variant, gene-based association study of hereditary melanoma using whole-exome sequencing

Background: Extraordinary progress has been made in our understanding of common variants in many diseases, including melanoma. Because the contribution of rare coding variants is not as well characterized, we performed an exome-wide, gene-based association study of familial cutaneous melanoma (CM) and ocular melanoma (OM). Methods: Using 11 990 jointly processed individual DNA samples, whole-exome

Self-Report Tool for Identification of Individuals With Coronary Atherosclerosis : The Swedish CardioPulmonary BioImage Study

BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from t

Class-switch recombination to IgA in the Peyer's patches requires natural thymus-derived Tregs and appears to be antigen independent

Our understanding of how class-switch recombination (CSR) to IgA occurs in the gut is still incomplete. Earlier studies have indicated that Tregs are important for IgA CSR and these cells were thought to transform into follicular helper T cells (Tfh), responsible for germinal center formation in the Peyer's patches (PP). Following adoptive transfer of T-cell receptor-transgenic (TCR-Tg) CD4 T cell

Data quality and patient characteristics in European ANCA-associated vasculitis registries : data retrieval by federated querying

Objectives This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic antibody-associated vasculitis (AAV) registries. Methods Through creation of the vasculitis-specific Findable, Accessible, Interoperable, Reusable, VASCulitis ontology, we harmonised

Willingness among food consumers to recycle human urine as crop fertiliser : Evidence from a multinational survey

Source-separating sanitation systems offer the possibility of recycling nutrients present in wastewater as crop fertilisers. Thereby, they can reduce agriculture's impacts on global sources, sinks, and cycles for nitrogen and phosphorous, as well as their associated environmental costs. However, it has been broadly assumed that people would be reluctant to perform the new sanitation behaviours tha

Prevalence and characteristics of asthma-chronic obstructive pulmonary disease overlap in routine primary care practices

Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP

High-Density Lipoprotein function is modulated by the SARS-CoV-2 spike protein in a lipid-type dependent manner

There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and

The chemical characterization of halo substructure in the Milky Way based on APOGEE

Galactic haloes in a Λ-CDM universe are predicted to host today a swarm of debris resulting from cannibalized dwarf galaxies. The chemodynamical information recorded in their stellar populations helps elucidate their nature, constraining the assembly history of the Galaxy. Using data from APOGEE and Gaia, we examine the chemical properties of various halo substructures, considering elements that s

Autoimmune effector mechanisms associated with a defective immunosuppressive axis in immune thrombocytopenia (ITP)

Immune thrombocytopenia (ITP) is an autoimmune disease characterized by an isolated thrombocytopenia and variable phenotype as some patients suffer no bleeding whilst others have bleeding from mild to severe, which may be fatal. This variability probably reflects the disease's complex pathophysiology; a dysregulated hyperreactive immune effector cell response involving the entire adaptive immune s

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Primärvården i det förebyggande arbetet FORSKARE: Jan Sundquist, Daniel Arvidsson, Matti Leijon, Kristina Sundquist KLINIK/INSTITUTION: Centrum för primärvårdsforskning, Primärvården Skåne, Inst. för kliniska vetenskaper – Malmö, Lunds universitet e-post: jan.sundquist@med.lu.se Det behövs fler hälsosatsningar och mer kvalitetssäkrad kunskap för att främja och förbättra skåningarnas folkhälsa och

https://www.vetenskaphalsa.se/wp-content/uploads/2010/01/10.JanSundqvist_prim%C3%A4rv%C3%A5rden-i-det-f%C3%B6rebyggande-arbetet1.pdf - 2026-05-17

Projektnamn

Projektnamn Region Skåne Direktiv Datum 2009-06-08 Dnr Projektdirektiv Projekt – Integrativ medicin inom Region Skåne Organisatorisk enhet Koncernledning Projektbeställare Rita Jedlert Projektledare Hans Du Rietz Datum 2009-10-08 Dokumentbeteckning Distributionslista Projekt- plan Projekt- direktiv Status- rapport Slut- rapport Godkännande av beställning Datum: Datum: Underskrift Beställare Unders

https://www.vetenskaphalsa.se/wp-content/uploads/2010/06/PROJEKTDIREKTIV-Integrativ-medicin-inom-Region-Sk%C3%A5ne-2009.pdf - 2026-05-17

arkstudier – STUDIEVÄGLEDARBLOGGEN

arkstudier – STUDIEVÄGLEDARBLOGGEN Hoppa till huvudinnehåll Hem Studievägledaren vid Institutionen för arkeologi och antikens historia i Lund Lära sig vara student Sök Sök Stäng Meny Meny STUDIEVÄGLEDARBLOGGEN Blandad information för studenter på Institutionen för arkeologi och antikens historia vid Lunds universitet arkstudier Sida 1 / 34 13 maj, 2026 | arkstudier Seminarium med panelsamtal: Oavs

https://arkstudier.blogg.lu.se/author/arkstudier/ - 2026-05-16

WPSS framsida 86

WPSS framsida 86 WORKING PAPERS IN SCANDINAVIAN SYNTAX 86 Gunlög Josefsson Object shift and optionality. An intricate interplay between syntax, prosody and information structure 1-24 Mayumi Hosono On Icelandic Object Shift 25-56 Mayumi Hosono Why Object Shift does not exist in Övdalian 57-80 Mayumi Hosono On Unshifted Weak Object Pronouns in the Scandinavian Languages 81-99 Eva Engels Local licens

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/WPSS_07.pdf - 2026-05-16

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1 Bertil Molde Översättarens ansvar för språket Ur Språkvård 1979:4, något nedkortad Vårt språk, det språk som vi har som moders- mål och som vi var och en av oss lever med större delen av vårt liv, det är självklart vars och ens egendom att vårda och förvalta. Men det är också något som ägs av alla andra som har samma språk som medel för tankar och känslor, för tal och skrift. Vi använder ordet s

https://www.sol.lu.se/fileadmin/_migrated/content_uploads/Molde1979.pdf - 2026-05-16

Genome-Wide Association Analysis of Pancreatic Beta-Cell Glucose Sensitivity

CONTEXT: Pancreatic beta-cell glucose sensitivity is the slope of the plasma glucose-insulin secretion relationship and is a key predictor of deteriorating glucose tolerance and development of type 2 diabetes. However, there are no large-scale studies looking at the genetic determinants of beta-cell glucose sensitivity. OBJECTIVE: To understand the genetic determinants of pancreatic beta-cell gluc

15_JurekPyrko

15_JurekPyrko LTHs 7:e Pedagogiska Inspirationskonferens, 30 augusti 2012 Abstract—Denna artikel beskriver 25 års erfarenheter från en ständig utveckling av kontinuerlig examination i form av litteraturtest som utgör obligatoriska delmoment i grund- och specialiseringskurser inom ämnet Energihushållning. Kunskapen bearbetas i flera steg i olika former (återkommande kunskap). Möjligheten att föra d

https://www.lth.se/fileadmin/lth/genombrottet/konferens2012/63_Pyrko.pdf - 2026-05-17

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Productivity of Non-Default Case Anton Karl Ingason University of Iceland Abstract This article is about productivity of non-default patterns in gram- mar. More specifically it is about the extension of non-default case patterns in syntax to novel items. The study draws on data from Icelandic syntax but addresses general questions about the nature of productivity. Contributions are made to the pic

https://projekt.ht.lu.se/fileadmin/_migrated/content_uploads/WPSS_85_Ingason.pdf - 2026-05-14

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1 In a new coop eration programme in the Middle East and North Africa region, coor dinated by the Inter national Legal Assist ance Consortium, the In stitute started work to further promote the app lication of human rights stan dards by courts in the region. a new cooperation programme was established in the Middle East and North Africa and the Institute established an office in Phnom Penh to mana

https://rwi.lu.se/app/uploads/2014/12/forwebsite.pdf - 2026-05-16

1012F.p65

1012F.p65 Department of Mechanics and Materials Structural Mechanics Doctoral Thesis ERIK SERRANO ADHESIVE JOINTS IN TIMBER ENGINEERING - MODELLING AND TESTING OF FRACTURE PROPERTIES Detta är en tom sida! Copyright © Erik Serrano, 2000. Printed by KFS i Lund AB, Lund, Sweden, October 2000. For information, address: Division of Structural Mechanics, LTH, Lund University, Box 118, SE-221 00 Lund, Sw

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm1000/web1012.pdf - 2026-05-17