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Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes G

Cross-laminated timber (CLT) as a prime example of an innovative product within the field of civil engineering has over the recent years attracted attention of the construction industry and engineers around the world. As a natural composite with different orientation of layers in addition to anisotropic properties of wood, CLT can be a challenging material in predictive numerical modelling. This i

The Eridanus II (EriII) 'ultra-faint' dwarf has a large (15 pc) and low-mass (4.3 × 103 M·) star cluster (SC) offset from its centre by 23 ± 3 pc in projection. Its size and offset are naturally explained if EriII has a central dark matter core, but such a core may be challenging to explain in a ΛCDM cosmology. In this paper, we revisit the survival and evolution of EriII's SC, focusing for the fi

Tonsillar cancer (TC) is a subset of head and neck cancer (HNC). TC incidence is sharply rising due to an increased prevalence of human papillomavirus (HPV) infection in the western world. Currently HPV status is considered during clinical staging due to its positive association to patient prognosis. Presumably, the relation between HPV and patient survival is dependent on the generation of an eff

We analyze the oxygen abundances of a stellar sample representative of the two major Galactic populations: the thin and thick disks. The aim is to investigate the differences between members of the Galactic disks and contribute to the understanding of the origin of oxygen chemical enrichment in the Galaxy. The analysis is based on the [O i] = 6300.30 Å oxygen line in high-resolution spectra (R ∼ 5

Cell-based therapies hold great promise in re-establishing organ function for many diseases, including untreatable lung diseases such as idiopathic pulmonary fibrosis (IPF). However, many hurdles still remain, in part due to our lack of knowledge about the disease-driving mechanisms that may affect the cellular niche and thereby possibly hinder the function of any transplanted cells by imposing th

How much is "anti" in the "anti-globalization" movement? And how much is "pro", and for what? In this paper I will analyze some common features, and divisions between organizations in the so called anti-globalization movement, with focus on the political articulations and different ways of political struggle. How is a common identity and a common adversary of the disparate movements constructed wi

Background The contribution of modifiable risk factors to the increasing global and regional burden of stroke is unclear, but knowledge about this contribution is crucial for informing stroke prevention strategies. We used data from the Global Burden of Disease Study 2013 (GBD 2013) to estimate the population-attributable fraction (PAF) of stroke-related disability-adjusted life-years (DALYs) asso

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disorder involving scarring of pulmonary tissue and a subsequent decrease in respiratory capacity, ultimately resulting in death. Tartrate resistant acid phosphatase 5 (ACP5) plays a role in IPF but the exact mechanisms are yet to be elucidated. In this study, we have utilized various perturbations of the bleomycin mouse model of IPF includ

BACKGROUND: After combat-related lower extremity amputations, patients rapidly lose bone mineral density (BMD). As serial dual x-ray absorptiometry (DXA) scans are rarely performed in this setting, it is difficult to determine the timeline for bone loss and recovery or the role of interventions. However, a strong correlation has been demonstrated between DXA BMD and computed tomography (CT) signal

We have investigated the Raman-Auger crossover of the Mn 2p non-radiative decays in bulk MnO. For the highest kinetic energy transition in the Mn 2p3p3p decay, Raman behaviour is observed up to approximate to 3.4 eV above the resonance energy (maximum of the L-3 absorption). In the case of the 2p3p3d and 2p3d3d transitions a similar situation occurs up to approximate to 5 eV above the resonance en

The core level photoemission and near edge X-ray photoabsorption spectra of guanine in the gas phase have been measured and the results interpreted with the aid of high level ab initio calculations. Tautomers are clearly identified spectroscopically, and their relative free energies and Boltzmann populations at the temperature of the experiment (600 K) have been calculated and compared with the ex

Popular Abstract in Swedish Immunsystemet är ett invecklat och komplext system som finns överallt i kroppen och som inte är begränsat till ett enda organ. Vi utsätts hela tiden för ”angrepp” från mikro-organismer (t.ex. bakterier eller virus) men också för främmande ämnen som kan vara skadliga eller giftiga. Immunsystemets huvudfunktion är att hjälpa kroppen att känna igen dessa ”angripare” och atThe overall aim of this PhD project was to gain insight into the incidence of primary immunodeficiency (PID) in southern Sweden and to optimize diagnostic and treatment measures for these patients. We estimated the occurrence rate of PID in the pediatric population of southern Sweden during a period of 4 years and described the demographic, clinical and immunological characteristics of the identif

The O, N, and C 1s core level photoemission spectra of the nucleobases cytosine and uracil have been measured in the vapor phase, and the results have been interpreted via theoretical calculations. Our calculations accurately predict the relative binding energies of the core level features observed in the experimental photoemission results and provide a full assignment. In agreement with previous

This dissertation places Pearl in the context of works by the English fourteenth-century contemplative writers (‘mystics’), as well as of patristic and other theological treatises, focusing on the theme of comprehending and speaking about a transcendent divine dimension. The purpose is to show that Pearl and the works of Julian of Norwich, Margery Kempe, Walter Hilton, Richard Rolle and the author

Popular Abstract in Swedish Blekinge tillhörde före freden i Roskilde 1658 Danmark. De östdanska provinserna erövrades av svenskarna och integrerades i det svenska riket. Övergångsproblematiken har i äldre forskning ofta diskuterats och analyserats med begrepp hämtade från en senare tids nationella föreställningar. Men var de motsättningar och konflikter som utvecklades i Blekinge efter övergångenThe object of this thesis is to examine the incorporation of the former Danish province of Blekinge into Sweden after the Treaty of Roskilde in 1658. This question has been analysed before but such studies have usually been coloured by the use of national ideas and notions born of a later age than the period under examination. This thesis analyses the so-called Transition Problem using theoretical

Sverige är ett utpräglat småföretagarland och mätt i antal bedrivs en klart övervägande del av företagen som enskild näringsverksamhet. Till skillnad från aktiebolag och andra juridiska personer, som hänför alla inkomster till inkomstslaget näringsverksamhet, ska inkomster eller utgifter för fysiska personer hänföras till endera av inkomstslagen näringsverksamhet, tjänst eller kapital. AvhandlingeSweden is a typical small-business country and, based on the numbers, a clear majority of the companies operate as sole traders. Unlike limited companies and other legal entities, which classify all income as business income, the income or expenditures of private persons are classified as either business, service or capital income. The main objective of this thesis is to systematically examine the