Sökresultat

A series of analogs with nitro or serinamide substituents at the C-2'-, C-5'-, or C-C-position of the combretastatin A-4 (CA4) B-ring was synthesized and evaluated for cytotoxic effects against heart endothelioma cells, blood flow reduction to tumors in SCID mice, and as inhibitors of tubulin polymerization. The synthesis of these analogs typically featured a Wittig reaction between a suitably fun

This is the first attempt to budget average current annual carbon (C) and associated greenhouse gas (GHG) exchanges and transfers in a subarctic landscape, the Lake Torneträsk catchment in northern Sweden. This is a heterogeneous area consisting of almost 4000 km2 of mixed heath, birch and pine forest, and mires, lakes and alpine ecosystems. The magnitudes of atmospheric exchange of carbon in the

Aims/hypothesis. We assessed how the role of genes genetic causation in causing maturity-onset diabetes of the young (MODY) alters the response to an oral glucose tolerance test (OGTT). Methods. We studied OGTT in 362 MODY subjects, from seven European centres; 245 had glucokinase gene mutations and 117 had Hepatocyte Nuclear Factor-1 alpha (HNF-1alpha) gene mutations. Results. BMI and age were si

Cardiovascular disease (CVD) is the leading cause of death globally. Inflammatory cardiomyopathies can be life-threatening, and the underlying mechanisms are not fully understood. This thesis aimed to investigate the underlying mechanisms driving the pathogenesis of myocarditis and septic cardiomyopathy, and to explore potential treatment strategies. In particular, we focused on the pro-inflammato

In this paper, an aerosol-based process is proven for imparting antibacterial property to textiles. Nanoparticles of copper and silver are produced by means of glow discharge between two electrodes in nitrogen at atmospheric pressure and passed through fabrics of cotton and polyester which act as filter media. The bactericidal performance of the nanofinished fabrics is assessed against Gram-positi

Unlike pathogens, which attack the host, commensal bacteria create a state of friendly coexistence. Here, we identified a mechanism of bacterial adaptation to the host niche, where they reside. Asymptomatic carrier strains were shown to inhibit RNA polymerase II (Pol II) in host cells by targeting Ser2 phosphorylation, a step required for productive mRNA elongation. Assisted by a rare, spontaneous

PURPOSE: The aim of this study was to set up reliable and reproducible culture conditions for 3D tumoroids derived from non-small cell lung cancer (NSCLC) cell lines to enable greater opportunity for successful cultivation of patient-derived samples.METHODS: Four NSCLC cell lines, two adenocarcinomas (A549, NCI-H1975) and two squamous cell carcinomas (HCC-95, HCC-1588), were first cultured in trad

UNLABELLED: Maintaining high-affinity antibodies after vaccination may be important for long-lasting immunity to malaria, but data on induction and kinetics of affinity is lacking. In a phase 1 malaria vaccine trial, antibody affinity increased following a second vaccination but declined substantially over 12 months, suggesting poor maintenance of high-affinity antibodies.CLINICAL TRIALS REGISTRAT

Modern solid-state klystron modulators generate high-voltage, high-power pulses by discharging energy stored in a capacitor bank. Such modulators require at least one capacitor charging unit supplying the energy released in pulsing. Traditional capacitor charging structures rely on AC/DC front-end units based on passive diode rectifiers in conjunction with high-frequency resonant converters. Howev

We provide a detailed characterization of the planetary system orbiting HD 85426 (TOI-1774). This bright G-type star (: 0.99;: 1.13; age: 7.4 Gyr; V mag: 8.25) hosts a transiting sub-Neptune, HD 85426 b, with an orbital period of 16.71 d and a blackbody equilibrium temperature of K. By jointly analysing HARPS-N RVs, TESS, and CHEOPS photometric data and using two different stellar activity mitigat

Popular Abstract in Swedish Inom svensk mjölkproduktion förekommer en hög frekvens av belastningsbesvär. Vid jämförelser mellan manliga och kvinnliga mjölkare har det visat sig vara stora skillnader avseende besvärsförekomst. Kvinnorna har rapporterat högre frekvens av problem i nästan alla kroppsdelar jämfört med männen. Dessutom har andelen hand- och handledsbesvär visat sig vara anmärkningsvärdThe aims of the thesis were to investigate the prevalence of the upper extremity musculoskeletal disorders in female milkers in relation to other occupational groups; to clarify the relationship between disorders and work environment, psychosocial and life style factors; to compare in a prospective study, pain, ache and discomfort reported by a questionnaire with clinical symptoms and sign; to exa

Background: The outlook for patients with esophageal and gastric (EG) cancer remains poor. Hence, there is a compelling need to identify novel treatment strategies and complementary biomarkers. Programmed death ligand 1 (PD-L1) and mismatch repair deficiency (dMMR) are putative biomarkers of response to immune-checkpoint blockade, but their prognostic value and interrelationship in EG cancer have

The serum concentration of YKL-40, a matrix protein of specific granules in neutrophils, was determined by RIA in 90 patients hospitalized with pneumonia of suspected bacterial origin. Of these, 64 were followed prospectively during antibiotic treatment with blood samples taken on day 0 (on admission and the start of treatment) and on days 1, 3, 5, 7, 10, and 21. Serum YKL-40 at admission was incr

BACKGROUND: Diet-related greenhouse gas emissions (GHGe) mainly comes from animal-sourced foods. As progressive changes are more acceptable for a sustainable food transition, we aimed to identify nutritionally adequate and culturally acceptable optimized diets ensuring a gradual reduction in GHGe, using observed diet from a large sample of French adults, while considering the mode of food producti

Background: Blood pressure control has a pivotal role in reducing the incidence and recurrence of stroke. May Measurement Month (MMM), which was initiated in 2017 by the International Society of Hypertension, is the largest global blood pressure screening campaign. We aim to compare MMM participants with and without a previous history of stroke and to investigate associations between national-leve

Type I interferons (IFNs) are essential for antiviral immunity, appear to represent a key component of mRNA vaccine-adjuvanticity, and correlate with severity of systemic autoimmune disease. Relevant to all, type I IFNs can enhance germinal center (GC) B cell responses but underlying signaling pathways are incompletely understood. Here, we demonstrate that a succinct type I IFN response promotes G

Cross-laminated timber (CLT) as a prime example of an innovative product within the field of civil engineering has over the recent years attracted attention of the construction industry and engineers around the world. As a natural composite with different orientation of layers in addition to anisotropic properties of wood, CLT can be a challenging material in predictive numerical modelling. This i