Filtyp
This thesis presents a study of advanced analytical techniques, for the characterization of actinide particles originating from the non-peaceful use of nuclear technology and from international inspections of the nuclear fuel cycle associated with non-proliferation agreements. The thesis is based on five papers, which will be referred to by Paper I-V in the text. Individual particle analysis has s
New Information Systems Development Methodologies (ISDMs) are suggested in the belief that their deployment would be beneficial to consultants in their work. A large number of ISDMs already exist but their value has been questioned and at the same time new methodologies continue to be introduced in an attempt to support and improve the practice of information systems development work. What is not
The paper analyses some properties that are obtained when using load current measurements to control DC-DC power converters. The analysis is made for the buck, boost, and buck-boost converters with current mode control. The two major properties obtained are low output impedance and an almost invariant control-to-output transfer function for different loads. It is shown that the use of the load cur
Popular Abstract in Swedish Denna avhandling presenterar resultat från experimentella studier av tensiders och enzymers beteenden vid modellytor. Ellipsometri var den i huvudsak använda tekniken i dessa undersökningar. Studier av tensidadsorption i statiska och dynamiska vätningssituationer initierades för att undersöka adsorptionsbeteenden i närheten av trefaslinjen under dynamisk vätning. I falThis thesis presents results from experimental studies of the interfacial behaviour of surfactants and enzymes at model surfaces. The main technique used throughout the work was ellipsometry. Studies of surfactant adsorption in static and dynamic wetting situations were performed to investigate adsorption behaviour close to the three-phase contact line (tpl) during dynamic wetting. It was demonst
Popular Abstract in Swedish Bakgrund Järn (med den kemiska beteckningen Fe, från latinets ferrum) är känt för de flesta som en beståndsdel i till exempel stål. Det många inte vet är att järn är nödvändigt för liv, så som det ser ut på jorden idag. Men det finns en annan sida av myntet: järn kan nämligen också vara giftigt. Som de allra flesta känner till rostar järn i närvaro av syre och vatten.Patients suffering from the deadly progressive neurodegenerative disease Friedreich's ataxia have reduced levels of expression of the protein frataxin. Yeast frataxin has been extensively studied in vitro, and has been shown to deliver iron to heme and iron-sulfur cluster biosynthesis, as well as to oligomerize in the presence of iron. In this dissertation metal-dependent oligomerization of fratax
It has been recently reported that both dynamic movement characteristics, as well as the duration of postures adopted during work, are important in the development of low back pain (LBP). This paper presents a video-based posture assessment method capable of measuring trunk angles and angular velocities in industrial workplaces. The interobserver reliability, system accuracy, and the relationship
This thesis concerns the analysis of anthropogenic substances of the compound class known as persistent organic pollutants (POPs). Sample preparation perspectives for the analysis of POPs in the environmental matrices water, soils and sediments are presented. This thesis features reasonably cheap and uncomplicated methodology capable of fast screening of POPs. It displays how quantitative extract
Background: Serum IgA antibodies against tissue transglutaminase (tTG) are reliable markers for celiac disease (CD), still the diagnostic performance of anti-tTG immunoassays can be improved. A novel ELISA, using fibronectin (FN) as tTG binding protein, was evaluated for the detection of anti-tTG antibodies in CD. Methods: Sera from 173 children with untreated CD and 97 controls were analyzed for
Cerebrospinal fluid (CSF) samples from 21 patients with a clinical diagnosis of Alzheimer's disease (AD) participating in a 5-year treatment study with the choline esterase inhibitor tacrin were retrospectively analyzed for the contents of beta-amyloid (Abeta42), total tau (T-tau) and phosphorylated tau (P-tau). A significant positive correlation between the level of P-tau and the number of sympto
In this first clinical trial liposome-encapsulated iodixanol, CT particles (CTP) were studied. The aims of the present trial were to assess the efficacy of CTP in CT and to determine the safety of different doses of CTP. A total of 47 healthy volunteers were enrolled in the present study. The CTP was administered at doses 10, 30, 70 and 100 mg encapsulated I/kg bw. Efficacy was assessed using sing
A method for the determination of electron density using a narrow beam attenuation geometry is described. The method does not require that the elemental composition of the phantom materials is known. The Hounsfield numbers for the phantom materials used were determined using five different CT scanners. A relationship between Hounsfield number and electron density can thus be established, which is
In the present paper, an optimization of the draw-in of an automotive sheet metal part has been carried out using Response Surface Methodology (RSM) and Space Mapping technique. The optimization adjusts the drawbead restraining force in the model such that the draw-in in the FE model corresponds to the draw-in in the physical process. The conclusion of this study is that Space Mapping is a very ef
Current atrial fibrillation (AF) management guidelines suggest that initially a decision must be made to apply either a rate control or rhythm control strategy in the individual patient. However, patients' selection remains substantially empirical and the strategy initially chosen often proves unsuccessful and alternative therapies must be adopted. Thus, it seems desirable to develop and apply tes
Popular Abstract in Swedish Sammanfattning Teknik är alltid skapad för en förväntad brukare i ett antaget sammanhang. Inom kommersiell luftfart är dessa antaganden när det gäller design tydliga. Såväl besättning som utrustning är certifierad för en viss typ av operationer i enlighet med flygplanets drifthandbok. Trots denna genomtänkta definition av användare i sitt sammanhang händer det ändå attAbstract Technology is always designed for an assumed user in an assumed context. In commercial aviation, these design assumptions are clearly spelt out in that both crew and equipment are certificated for a specific operation as stated in the aircraft flight manual. Despite this well defined user context, the designed-for and the real contexts often differ enough so that adaptations of working p
The anticonvulsive effect of lidocaine was evaluated in 46 newborn infants with severe, recurrent seizures. Before the lidocaine all infants were being given phenobarbital, and 22 infants were also treated with diazepam. Different dosages of lidocaine were tested. A loading dose of 2 mg/kg followed by i.v. infusion of 6 mg/kg/hour was the most effective dosage and had an immediate anticonvulsive e
I-131 radionuclide therapy studies have not shown a strong relationship between tumor absorbed dose and response, possibly due to inaccuracies in activity quantification and dose estimation. The goal of this work was to establish the accuracy of I-131 activity quantification and absorbed dose estimation when patient-specific, 3-dimensional (3D) methods are used for SPECT reconstruction and for abs
Background: There are at least three broad conceptual models for the impact of the social environment on adult disease: the critical period, social mobility, and cumulative life course models. Several studies have shown an association between each of these models and mortality. However, few studies have investigated the importance of the different models within the same setting and none has been p
