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BACKGROUND: Shiga toxin (Stx) is the main virulence factor of enterohemorrhagic Escherichia coli, a food-borne pathogen that colonizes the intestine causing gastroenteritis and, in severe cases, hemolytic uremic syndrome. Stx was shown to induce ATP release in vivo and in vitro and blockade of purinergic P2X receptors inhibited its cytotoxicity. Here we investigated the intracellular signaling eve
Photonics technologies play a crucial role in driving technological advancements within the agrifood industry, aiming to deliver a sustainable food and agriculture, and offering healthy, nutritious and safe food for all of us. Particularly, optical sensors and imaging systems, together with machine-learning processing and advanced lighting, play a pivotal role in monitoring crop and soil health wi
Opioid use disorders (OUD) is a relapsing condition with high mortality. Opioid maintenance treatment (OMT) reduces heroin use, and overall morbidity and mortality. The prevalence of psychiatric and substance use disorders, potential baseline predictors for psychiatric hospitalization, and psychiatric diagnoses at follow-up were investigated and may give hints about possible preventative strategie
The self-assembly of an arylazopyrazole-based photosurfactant (PS), based on cetyltrimethylammonium bromide (CTAB), and its mixed micelle formation with CTAB in aqueous solution was investigated by small angle neutron and X-ray scattering (SANS/SAXS) and UV-vis absorption spectroscopy. Upon UV light exposure, PS photoisomerizes from E-PS (trans) to Z-PS (cis), which transforms oblate ellipsoidal m
BACKGROUND: Lynch syndrome is a rare familial cancer syndrome caused by pathogenic variants in the mismatch repair genes MLH1, MSH2, MSH6, or PMS2, that cause predisposition to various cancers, predominantly colorectal and endometrial cancer. Data are emerging that pathogenic variants in mismatch repair genes increase the risk of early-onset aggressive prostate cancer. The IMPACT study is prospect
The interaction of protein S with membranes and subsequent combination with complement C4b-binding protein (C4BP) was studied. Protein S interacted with phospholipid vesicles in a calcium-dependent manner typical of other vitamin K-dependent proteins. Association of C4BP with protein S showed no apparent selectivity for membrane-bound or solution phase protein S. When bound to the membrane, the pr
CHEOPS (CHaracterising ExOPlanet Satellite) is an ESA S-class mission that observes bright stars at high cadence from low-Earth orbit. The main aim of the mission is to characterize exoplanets that transit nearby stars using ultrahigh precision photometry. Here, we report the analysis of transits observed by CHEOPS during its Early Science observing programme for four well-known exoplanets: GJ 436
Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. Ever since the early 2000’s, no major improvement of patient outcomes occurred. Immu
We use data from the 17th data release of the Apache Point Observatory Galactic Evolution Experiment (APOGEE 2) to contrast the chemical composition of the recently discovered Gaia Enceladus/Sausage system (GE/S) to those of 10 Milky Way (MW) dwarf satellite galaxies: LMC, SMC, Boötes I, Carina, Draco, Fornax, Sagittarius, Sculptor, Sextans, and Ursa Minor. Our main focus is on the distributions o
Background: Metastatic breast cancer (MBC) is the main cause of breast cancer-related death. The outcome of MBC varies, and there is a lack of biomarkers to aid in prognostication. The primary aim of this study was to evaluate the prognostic value of gene expression (GEX) signatures in the primary tumor (PT) and distant metastasis (DM) for progression-free survival (PFS) and overall survival (OS).
Popular Abstract in Swedish Vad är egentligen kristen etik? Hur lär människor sig vad som är rätt och fel? Varför förändras normer och värderingar? Sådana stora och viktiga frågor får en konkret belysning i denna avhandling som undersöker normer och värderingar i svensk frikyrklighet. Lite ironiskt sa man förr att frikyrkliga hade en "syndakatalog": de fick exempelvis inte snusa, dansa eller ha sThe dissertation describes and characterises ethical reflection in the Swedish Free Churches during the period from the 1930s to the 1990s. It is built primarily on two sources of material. The first one is a summary of discussions and statements on marriage, divorce and remarriage from books, journals and papers, mainly from two denominations: the Swedish Covenant Church and the Örebromission. Th
The electronic structure of GaAs (100) grown by low-temperature molecular beam epitaxy was investigated by means of photoemission spectroscopy. Slight differences are found in the valence band spectra of GaAs layers grown at different As-2/Ga flux ratios. Analysis of As 3d core level spectra does not indicate qualitative differences in respect to high temperature grown GaAs (100) layers. The Ga 3d
This study of stress-related antinuclear antibody (ANA) reactivity was undertaken with the objective of improving clinical ANA testing. ANA was determined by parallel enzyme-linked immunosorbent assays of crude nuclear protein antigen extracted from HEp-2 cells either grown under optimal conditions (providing nonstress ANA antigen) or exposed to stress (providing stress ANA antigen). The stress st
Popular Abstract in Swedish Studien behandlar bibelbruket i den grekiska systematiska samlingen av Apophthegmata Patrum ( kenfädernas tänkespråk). Efter en inledande genomgång av tidigare forskning på biblebruk i allmänhet och det i tänkespråken i synnerhet formuleras undersökningens syfte så: att beskriva hur bibeltexten kontextualiseras, dvs. hur texten infogas i den undervisning och de ideal soThis study is devoted to the use of the Bible in the Greek systematic collection of Apophthegmata Patrum (AP). After an introductory survey of earlier research on the use of Scripture in general, and that of AP in particular, the main purpose of the investigation is formulated: to describe how the Bible text is contextualized, i.e., how the text is integrated with the teachings and ideals in the s
The emission spectra of lithium orthosilicates (Li4SiO4) ceramics have been measured in the range of 1.8-5.8 eV under irradiation by 6-30 eV photons or 1-30 keV electrons at 6-300 K. The tunnel recombination phosphorescence, as well as luminescence, stimulated by 1.5-2.5 eV photons has been detected in the sample preliminarily irradiated at 6 or 80 K. The main peaks of thermally stimulated lumines
Popular Abstract in Swedish Bomärken har använts som ägarbeteckning och signatur i Norden in på 1800-talet, och i vissa reliktområden intill nutid. Bomärkena återfinns t.ex. i mantalslängder, jordaböcker och bouppteckningar, men även inskurna på äldre redskap, husgeråd och annat lösöre. Bomärkena har av somliga forskare ansetts ha utformats slumpvis, enbart med syftet att kunna skilja en bomärkesThe pioneering academic research on Merchant Marks (also known as identity marks, personal marks, ownership marks, identification marks, Hausmarken, Hofmarken, Marques de Propriété, bomärken) was done by professor Homeyer (1870). Since 1870 there has been an ongoing debate among scholars whether Merchant Marks are simply formed by chance and coincidence, as stated by Rehnberg (1938, 1951), Scheffe
In this paper we discuss the dynamic nature of mobile usage, and how this impacts on design and evaluation, particularly in an industrial setting. We argue that current industry oriented design tools need to be extended to cater more effectively to the highly dynamic and context-dependent nature of mobile usage -- we suggest more focus should be put on doing instead of on being. In order to achiev
Popular Abstract in Swedish Membranproteiner är tämligen svåra att digerera med enzym som trypsin. Mindre specifika enzym såsom elastase och pepsin har dock visat sig mer effektiva. Databassökningar med dessa icke-tryptiska peptider är mindre verkningsfulla pga avsaknaden av laddning vid peptidens N-terminal och C-terminal samt brist på sekvensspecificitet. Vi beskriver en metod med specifik N-teMembrane proteins are fairly refractory to digestion especially by trypsin. Less specific proteases like elastase and pepsin are much more effective. However database searching using non-tryptic peptides is much less effective due to the lack of charge localisation at the N- and C-termini and the absence of sequence specificity. We describe a method for N-terminal specific labelling of peptides fr
Hjalmar Söderberg (1869–1941) published some seventy short stories in five collections, Historietter (1898), Främlingarna (1903), Det mörknar öfver vägen (1907), Den talangfulla draken (1913) and Resan till Rom (1929). The present study explores Söderberg’s short fiction from a genre-historical and genre-theoretical perspective. It investigates the characteristic traits of Söderberg’s short-story
