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Background: In cardiovascular disease, prevention strategies targeting standard modifiable cardiovascular risk factors (SMuRFs; hypertension, diabetes, hypercholesterolaemia, and smoking) are crucial; however, myocardial infarction in the absence of SMuRFs is not infrequent. The outcomes of individuals without SMuRFs are not well known. Methods: We retrospectively analysed adult patients with firs

Extensive diversity has been identified in the human heavy chain immunoglobulin locus, including allelic variation, gene duplication, and insertion/deletion events. Several genes have been suggested to be deleted in many haplotypes. Such findings have commonly been based on inference of the germline repertoire from data sets covering antibody heavy chain encoding transcripts. The inference process

We investigate the origin of close-in planets and related phenomena orbiting white dwarfs (WDs), which are thought to originate from orbits more distant from the star. We use the planetary architectures of the 75 multiple-planet systems (four, five, and six planets) detected orbiting main-sequence stars to build 750 dynamically analogous templates that we evolve to the WD phase. Our exploration of

This article describes and critically examines the challenging task of compiling The London–Lund Corpus 2 (LLC–2) from start to end, accounting for the methodological decisions made in each stage and highlighting the innovations. LLC–2 is a half-a-million-word corpus of contemporary spoken British English with recordings from 2014 to 2019. Its size and design are the same as those of the world's f

Proteomics Data Collection (ProDaC) is an EU-funded Coordination Action within the 6th framework programme. It aims to simplify the publication, dissemination and utilization of proteomics data by establishing standards that will support broad data collection from the research community. As a part of ProDaC, regular workshops are organized on a half-yearly basis to enable communication and discuss

The retail sector is facing fundamental transformations in nearly every part of the value chain, affecting the need for competence development in many retail professions. As most learning at work is informal and there is a deficit of studies of how such learning takes place in specific professions, systematized work with competence development is hampered. We therefore investigated the informal le

The title of this thesis is The Reading Machine. Aspects of Image and Book in the Works of Anders Billow 1923 – 1953. My aim is to revise and complement the historical understanding of the establishing of the modernistic “new typography” within the theory and practice of graphic design. A wider ambition is to, through example, better clarify the surrounding society’s influence on design and how ne

Protein-carbohydrate interactions are of central role in all living organism. In the studies presented in this thesis several strategies for engineering such interactions have been investigated. In the first study the binding affinity of a carbohydrate binding module (CBM) was improved a 100-fold through affinity maturation. Also, in that study it was discovered that all the selected, matured muta

Broadening conventional sociological concerns, this paper establishes a social psychological account of queer theory, and an associated understanding of subject formation, in order to examine the relationship between the continuously emerging self and the dressed body by taking its departure in the concept and phenomenon of cross-dressing. Focusing the interrelationship between bodily gestures and

Dendritic cells (DC) are a heterogeneous lineage of bone-marrow-derived leukocytes that serve as the link between innate and adaptive immunity. They are professional antigen-presenting cells that play an important protective and regulatory role in both health and disease. This thesis is based upon six original papers that deal with the function and transcription of human DCs, with focus on their r

Directions are given for demonstrating various topics from the other book chapters: The wave-nature of light, singlet oxygen, chromatic adaptation of cyanobacteria, the properties of the human visual system, photoconversion of rhodopsin, photosynthesis of previtamin D, spectral properties of chlorophyll, photoconversion of protochlorophyllide, separation of chloroplast pigments, photoadaptation of

Popular Abstract in Swedish Olika toleransmekanismer kontrollerar immunsystemets aktivitetThe immune system has evolved regulatory mechanisms in order to balance the effects of deleterious immune responses. Such immunological tolerance may be specifically acquired by lymphocytes, although different cells of the immune system participate in the induction and maintenance of tolerance. This thesis work is based on investigations of different tolerance mechanisms induced in CD4+ T lymphocy