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Extensive diversity has been identified in the human heavy chain immunoglobulin locus, including allelic variation, gene duplication, and insertion/deletion events. Several genes have been suggested to be deleted in many haplotypes. Such findings have commonly been based on inference of the germline repertoire from data sets covering antibody heavy chain encoding transcripts. The inference process

We investigate the origin of close-in planets and related phenomena orbiting white dwarfs (WDs), which are thought to originate from orbits more distant from the star. We use the planetary architectures of the 75 multiple-planet systems (four, five, and six planets) detected orbiting main-sequence stars to build 750 dynamically analogous templates that we evolve to the WD phase. Our exploration of

This article describes and critically examines the challenging task of compiling The London–Lund Corpus 2 (LLC–2) from start to end, accounting for the methodological decisions made in each stage and highlighting the innovations. LLC–2 is a half-a-million-word corpus of contemporary spoken British English with recordings from 2014 to 2019. Its size and design are the same as those of the world's f

The retail sector is facing fundamental transformations in nearly every part of the value chain, affecting the need for competence development in many retail professions. As most learning at work is informal and there is a deficit of studies of how such learning takes place in specific professions, systematized work with competence development is hampered. We therefore investigated the informal le

OBJECTIVE: To clarify, using an extended adoption design, the sources of parent-offspring transmission for anxiety disorder (AD) and its major subforms and their familial cross-generational relationship with major depression (MD). METHODS: Offspring (born 1960-1992) and their parents, from six family types (intact, not-lived-with biological father or mother, lived-with step-father or step-mother,

Background: Harmful glucose exposure and absorption remain major limitations of peritoneal dialysis. We previously showed that inhibition of sodium glucose cotransporter 2 did not affect glucose transport during peritoneal dialysis in rats. However, more recently we found that phlorizin, a dual blocker of sodium glucose co-transporter 1 and 2, reduces glucose diffusion in peritoneal dialysis. Ther

Edinburgh was an Enlightenment city of regional, national and global influence. But how did the people of Enlightenment Edinburgh understand and order their world? How did they encounter, compare and produce different kinds of spaces, from the urban to the world scale? And how did this city set the universal standards by which other places should be judged and transformed?The Geographies of Enligh

Due to an increased number of complex multi- and long-term ill patients, healthcare and nursing provided in patients' homes are expected to grow. Teamwork is important in order to provide effective and safe care. As care becomes more complex, the need for teamwork in home care nursing increases. However, the literature on teamwork in the patients' home environment is limited. The aim of this study

This paper explores wartime relationships and the culture of armed groups in the Democratic Republic of Congo (DRC). Without exceptions, the crises in the Congo must be framed in local-global correlations, i.e. in terms of criminal network activities and its linkages to mining businesses and exploitation of natural resources. In the eastern DRC the boundaries between the different armed groups and

The title of this thesis is The Reading Machine. Aspects of Image and Book in the Works of Anders Billow 1923 – 1953. My aim is to revise and complement the historical understanding of the establishing of the modernistic “new typography” within the theory and practice of graphic design. A wider ambition is to, through example, better clarify the surrounding society’s influence on design and how ne

Protein-carbohydrate interactions are of central role in all living organism. In the studies presented in this thesis several strategies for engineering such interactions have been investigated. In the first study the binding affinity of a carbohydrate binding module (CBM) was improved a 100-fold through affinity maturation. Also, in that study it was discovered that all the selected, matured muta

Broadening conventional sociological concerns, this paper establishes a social psychological account of queer theory, and an associated understanding of subject formation, in order to examine the relationship between the continuously emerging self and the dressed body by taking its departure in the concept and phenomenon of cross-dressing. Focusing the interrelationship between bodily gestures and

BackgroundVasovagal reflex is the most common form of syncope, but the pathophysiological mechanisms that initiate the reflex are not well understood. We aimed to study supine and early orthostatic levels of the neurohormones involved in control of circulatory homeostasis in relation to the onset of tilt‐induced vasovagal syncope (VVS).Methods and ResultsA total of 827 patients who were investigat

Increased scholarly interest in ideas, goods and people that crossed the boundaries between modern empires (c. 1850-1914), known as transimperial history, has directed attention to microhistorical cases of individuals with transimperial careers. Such life trajectories are interesting in themselves, but their representativeness and broader significance for modern imperial history is often unclear.

Droplets generated by talking and coughing play a major role in the spreading of COVID-19. There is thus a need for accurate measurements of the physical properties of exhaled droplets, including their number, speed and direction.Several challenges are associated with imaging coughed droplets such as high droplet speed near the mouth where both short exposure time to freeze droplet motion and kHz