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Patients with type 2 diabetes (T2D) are at high risk of cardiovascular complications. Novel anti-diabetic medications such as sodium-glucose cotransporter-2 inhibitors (SGLT-2i) and Glucagon-like peptide-1 receptor agonists (GLP-1RA) have been shown to possess cardiac and renal protective effects beyond their ability to lower plasma glucose. Use of SGLT-2i and GLP-1RA in patients with T2D and hear
This chapter aims to explore community energy (CE)—energy communities that are established and run by private citizens—in four Eastern European countries. The chapter first analyses general contextual conditions supporting the diffusion of CE initiatives in the Baltic Sea Region. Subsequently, it reports the findings of four case studies from Estonia, Latvia, Lithuania, and Poland illustrating som
Real-time communication over Ethernet is becoming important in various application areas of cyber-physical systems such as industrial automation and control, avionics, and automotive networking. Since such applications are typically time critical, Ethernet technology has been enhanced to support time-driven communication through the IEEE 802.1 TSN standards. The performance and stability of contro
This paper presents an innovative study of the port system of Rome in Imperial times through the application of an integrated approach to both archaeological analysis and material evidence. Specifically, it seeks to provide a more complete contextualization and understanding of the port system of Rome by focusing on the exploration of the physical geography of the river Tiber and its transformatio
Inflammatory airway diseases and lower respiratory tract infections are leading causes of severe illness, disability and death worldwide. Much of today´s hypotheses about the underlying inflammatory processes and pathogenic contribution by immune cells come from in vitro experiments or animal models. As a consequence, our knowledge of the actual immunopathological events in real patient tissues is
The most common and lethal bacterial pathogens have co-evolved with the host. Pathogens are the aggressors, and the host immune system is responsible for the defence. However, immune responses can also become destructive, and excessive innate immune activation is a major cause of infection-associated morbidity, exemplified by symptomatic urinary tract infections (UTIs), which are caused, in part,
In this perspective article, we provide recommendations for strengthening the policy framework for protecting the Baltic Sea from agricultural nutrient pollution. The most striking weakness is the lax implementation of prescribed abatement measures, particularly concerning manure management, in most countries. Institutions of the EU should also be leveraged for achieving Baltic Sea Action Plan (BS
The Covid-19 pandemic has had a huge influence in almost all areas of life, affecting societies, economics and health care systems worldwide. The paediatric cardiology community is no exception. As the challenging battle with Covid-19 continues, professionals from the Association for the European Paediatric and Congenital Cardiology (AEPC) receive many questions regarding Covid-19 in a Paediatric
Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes pa
Purpose: The aim of this study is to explore teachers’ experience and understanding of classroom communication after participating in a speech-language pathologist (SLP) led in-service training on classroom communication. Method: This qualitative study used a focus group approach to explore how teachers describe their classroom communication. Twenty primary-school teachers participated. Thematic a
The response of soft colloids to crowding depends sensitively on the particles' compressibility. Nanogel suspensions provide model systems that are often studied to better understand the properties of soft materials and complex fluids from the formation of colloidal crystals to the flow of viruses, blood, or platelet cells in the body. Large spherical nanogels, when embedded in a matrix of smaller
We report on an experimental demonstration of spatially-resolved detection of atomic hydrogen in flames using a single-ended configuration yielding 656-nm lasing in the backward direction upon 2-photon pumping with 205-nm femtosecond laser pulses. Spatial resolution is achieved by temporally-resolved detection of the backward lasing using a streak camera. The method is demonstrated in CH4/O2 flame
The task of assessing the extent of a gas release during pipeline emergency situations is challenging. Traditional methodologies for risk analysis require significant computer capabilities and time; factors that have traditionally made emergency response teams unable to use gas dispersion modelling during real incidents.
Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear transcriptional response commonly described as the mitochondrial unfolded protein response (UPRmt). Despite extensive studies of UPRmt pathways in animal and fungal systems, very little is known about h
The transcriptional response of hosts to genetically similar pathogens can vary substantially, with important implications for disease severity and host fitness. A low pathogen load can theoretically elicit both high and low host responses, as the outcome depends on both the effectiveness of the host at suppressing the pathogen and the ability of the pathogen to evade the immune system. Here, we i
Damage detection systems are usually developed and optimized based on the methods of damage detection system reliability. This implies that the later purpose of a damage detection system namely e.g. the employment of the structural integrity management is not directly accounted for. This paper addresses thus the issue of optimizing a damage detection system in the perspective its utilization for t
The propagation of laminar and turbulent expanding flames subjected to Darrieus-Landau (DL), hydrodynamic instability was experimentally studied by employing stoichiometric H2/O2/N2 flames under quiescent and turbulent conditions performed in a newly developed medium-scale, fan-stirred combustion chamber. In quiescent environment, DL unstable laminar flame exhibits three-stage propagation, i.e. sm
