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Body lift, drag and power are relatively higher in large-eared than in small-eared bat species

Bats navigate the dark using echolocation. Echolocation is enhanced by external ears, but external ears increase the projected frontal area and reduce the streamlining of the animal. External ears are thus expected to compromise flight efficiency, but research suggests that very large ears may mitigate the cost by producing aerodynamic lift. Here we compare quantitative aerodynamic measures of fli

Colorectal cancer-infiltrating T lymphocytes display a distinct chemokine receptor expression profile

Background: T lymphocytes exert important homeostatic functions in the healthy intestinal mucosa, whereas in case of colorectal cancer (CRC), infiltration of T lymphocytes into the tumor is crucial for an effective anti-tumor immune response. In both situations, the recruitment mechanisms of T lymphocytes into the tissues are essential for the immunological functions deciding the outcome. The recr

Angiotensin-Converting Enzyme Inhibitors and Angiotensin II Receptor Blockers Are Associated With Improved Outcome but do Not Prevent New-Onset Atrial Fibrillation After Acute Myocardial Infarction

Background-Treatment with renin-angiotensin system (RAS) inhibitors might restrain the structural/electrical remodeling associated with atrial fibrillation (AF). Limited evidence exists regarding the potential benefits of RAS inhibition post-acute myocardial infarction (AMI) in patients with AF. This study sought to assess the association between RAS inhibition and all-cause mortality and new-onse

Are REDD+ community forest projects following the principles for collective action, as proposed by Ostrom?

Forested countries in the global south that have agreed to engage in REDD+, a policy mechanism for addressing climate change, are receiving support to improve laws, policies, systems and structures. As a mechanism initiated at the global level and seeking to use forests to address a global commons crisis (atmospheric carbon concentration), understanding how REDD+ translates into implementation at

Recovery From Heavy Vocal Loading in Women With Different Degrees of Functional Voice Problems

Type of Study: This is a longitudinal, case-control clinical trial. Objectives: This study aims to track recovery time following a vocal loading task (VLT) imposing vocal fatigue and to explore if patients with functional dysphonia (FD) are worse affected by vocal loading, and if these patients take longer than others to recover. Methods: Fifty (n = 50) female participants in four vocal subgroups

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This doctoral thesis uses a meta-critical method with an epistemological approach. The corpus consists of the doctoral theses presented in the United States about the novels of the Peruvian-Spanish writer and Nobel Prize winner in 2010 Mario Vargas Llosa, one of the most outstanding Spanish-speaking authors, with an extensive literary production. The study covers the 56 doctoral theses presented b

Evaluation of a city logistics business model: Impact of cost, revenue and goods flow on profitability

Purpose Many city logistics initiatives have failed to become economically sustainable. The purpose of this paper is to explain the impacts of cost, revenue and goods flow variables on the economic performance of a business model for city logistics. Design/methodology/approach A cost/benefit analysis, with data from transport providers and the municipality, on a six-month pilot implementation of a

The city logistics-based business model: a series of components

PurposeEmpirical studies show that 96% of the city logistics projects failed to become permanent, mainly due to the lack of sustainable business models (Quak et al., 2014; Malhene et al., 2012). Accordingly, it was concluded that the need of business model specifically designed for city logistics is high (Benjelloun, 2010). However, researchers have yet to describe the components and their interre

Downregulation of Thromboxane A2 Receptor Occurs Mainly via Nuclear Factor-KappaB Signaling Pathway in Rat Renal Artery

Thromboxane A2 (TXA2) acts on TXA2 receptors (TP) to regulate renal artery blood flow and subsequently contributes to the pathogenesis of renal ischemia. The present study was designed to examine if nuclear factor-kappaB (NF-B) signaling pathway is involved in the downregulation of TP receptors in rat renal artery. Rat renal artery segments were organ cultured for 6 or 24 h. Downregulation of TP r

Implicit les applied to isothermal swirling coaxial jets

This work is devoted to the analysis of the interaction of two coaxial jet with swirling flow using Large Eddy Simulation methodology to reproduce the case of Roback and Johnson. The eight - flat - vanes in the annular nozzle are the precursor of the swirling annular jet with high swirl number. An implicit LES model was used, this model uses mesh size as filter width so no sub-grid model is requir

Calibrated resilience landscapes of composite protection : Theoretical grounding of an empirical approach

The notion of societal safety and security has recently been raised to deal with a composite landscape of diverse threats and vulnerabilities. The concept of resilience has gained currency in recent years in many contexts as an alternative to prevalent failure-oriented safety approaches. In order to be meaningful in a societal safety/security context, the resilience concept must be translated to a

Fouling and cleaning of membranes in biorefineries

Wood components such as cellulose, lignin and hemicelluloses all have potential to be used in biobased value-added products. Once extracted from the wood these components have to be separated and purified from co-extracted compounds. Membrane filtration can be used to achieve this separation and is believed to play an important role in biorefineries.Fouling is the single greatest obstacle to the i

Clinical application and psychometric properties of a norwegian questionnaire for the self-assessment of communication in quiet and adverse conditions using two revised APHAB subscales

Background: Difficulty in following and understanding conversation in different daily life situations is a common complaint among persons with hearing loss. To the best of our knowledge, there is currently no published validated Norwegian questionnaire available that allows for a self-assessment of unaided communication ability in a population with hearing loss. Purpose: The aims of the present st

Business Model Experimentation for Circularity: Driving sustainability in a large international clothing retailer

Business model experimentation for sustainability is an intentional and systematic approach to identify, test and learn about value creation strategies that could be adopted by a business in response to current unsustainable trajectories. For businesses such as large clothing retailers the need to alter course is acute as pressure builds from economic, environmental and social angles. The circular

Single-shot, spatially-resolved stand-off detection of atomic hydrogen via backward lasing in flames

We report on an experimental demonstration of spatially-resolved detection of atomic hydrogen in flames using a single-ended configuration yielding 656-nm lasing in the backward direction upon 2-photon pumping with 205-nm femtosecond laser pulses. Spatial resolution is achieved by temporally-resolved detection of the backward lasing using a streak camera. The method is demonstrated in CH4/O2 flame

CATES (Consequence assessment tool for pipelines emergency situations)

The task of assessing the extent of a gas release during pipeline emergency situations is challenging. Traditional methodologies for risk analysis require significant computer capabilities and time; factors that have traditionally made emergency response teams unable to use gas dispersion modelling during real incidents.

The transcription factor ANAC017 is a key regulator of mitochondrial proteotoxic stress responses in plants

Impaired mitochondrial translation or reduced mitochondrial protein import can lead to imbalances in mitochondrial protein composition. Such mitochondrial proteotoxic stresses can trigger a nuclear transcriptional response commonly described as the mitochondrial unfolded protein response (UPRmt). Despite extensive studies of UPRmt pathways in animal and fungal systems, very little is known about h

Host transcriptional responses to high-and low-virulent avian malaria parasites

The transcriptional response of hosts to genetically similar pathogens can vary substantially, with important implications for disease severity and host fitness. A low pathogen load can theoretically elicit both high and low host responses, as the outcome depends on both the effectiveness of the host at suppressing the pathogen and the ability of the pathogen to evade the immune system. Here, we i